Clinical Trial Search

Primary: Hopkins Verbal Learning Test (HVLT) Total Recall — 17.27; 18.00; 15.27; 17.50 units on a scale

Primary: Proportion of Patients Abstinent From Marijuana During Weeks 7 and 8 of the Trial — 14; 12 participants

Primary: Demand Elasticity — 0.027; 0.032 cigarettes/dollar

Primary: %BMIp95 — -1.9; -1.2; -1.5 percent

Primary: Brain Activation During Functional Magnetic Resonance Imaging (fMRI) in Response to a Stress Modulated Cue Induced Craving Task (DSNBACK) — -26.1562; -45.2123; 18.4989…

Primary: Abstinence — 71.4; 16.6 percentage of participants

Primary: Recruitment Feasibility — 10 participants per month

Primary: Change in Clinical Institute Withdrawal Assessment for Alcohol (CIWA) Score — -2.76; 1.01 units on a scale

Primary: Change in Dopamine Levels at Baseline and After Drug of Dependence Administration as Confirmed by PET Images. — 0.0388; 0.033; 0.0285; 0.0368 mm^3

Primary: Number of Cocaine Non-use Days — 10.1; 17.1; 9.3; 14.1 Number of Days

Primary: Regional Availability of Metabotropic Glutamate Type-5 Receptors (mGluR5) — 36.48; 32.19; 25.67; 22.41 mL*cm^3 — p=0.035

Primary: Change in Average Waiting Time From First Contact to Treatment — .253; 4.610; 4.723; 3.520 Change in days

Primary: Immediate Memory Task

Primary: Illicit-positive Urines During Treatment and Follow-up — 0; 0; 1; 1 Participants

Primary: The Percentage of Opiate- and Cocaine-negative Urine Samples — 44.9; 64.6 percentage of urine samples — p=.05

Primary: Retention Without Relapse to Heroin Addiction (Measured at Month 6) — 54; 16; 11 Participants

Primary: % Cocaine-Negative Urine Specimens Per Participant — 42.2; 59.1; 51.0 % negative specimens per participant — p=0.177

Primary: Craving — 6.53; 7.0; 4.74; 4.43 scores on a scale — p=0.05

Primary: Subjective Reinforcement Self-report Scales — 4.8; 4.8; 9.5; 9.3 units on a scale

Primary: Percentage of Positive Toxicology Swabs for Illicit Substances — 81.3; 79.1; 86.2; 82.3 percentage of positive toxicology screen

Primary: Number of Participants With New Crime — 5; 3 Participants

Primary: Percentage of Monthly Urine Samples That Are Negative for Cocaine — 51.8; 79.3 percentage of urine samples — p=.004

Primary: Alcohol Abstinence — 82.8; 60.2 percentage of participants — p=<0.001

Primary: TB Treatment Completion Rates in Prison — 114; 127 Participants — p=0.08

Primary: PARS Help-Seeking Scale — 0.57; 0.53 units on a scale

Primary: Baseline Neural Flavor Cue-reactivity at Baseline — 0.08; 0.23; 0.10; 0.14 percentage of BOLD signal change

Primary: Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Total Score — 23.5; 20.4 units on a scale

Primary: Continuous Smoking Abstinence in the Last 4 Weeks of Treatment Continuous Smoking Abstinence in the Last 4 Weeks of Treatment — 2; 5; 6 participants

Primary: Puffing Topography: Puff Duration — 1.99; 2.06; 2.66; 1.87 seconds

Primary: Pattern of Crack Cocaine Use — 14.3; 40.7 percent of negative cocaine samples