Phase 2 N=60 Prevention of Alcohol Intolerance
Alcohol Sensitivity
Primary: Mean Area of Skin Erythema (Skin Redness) — 3.968; 1.739 centimeters^2
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=360 Alcohol Metabolism and Disease Risk in Asians
Healthy
Primary: Peak Number of Alcohol Drinks Consumed in a Day — 3.7; 4.2; 3.4; 3.0 drinks — p=.81
Phase 2 N=32 Phase IIa Study of Fomepizole for Acetaldehyde Toxicity After Ethanol Exposure in Subjects With Altered Ethanol Metabolism
Aldehyde Dehydrogenase-2 (ALDH2) Deficiency
Primary: Number of Participants With Adverse Events (AEs), Serious AEs, and AEs Leading to Study Discontinuation — 13; 6; 8; 21 Participants
N/A N=94 Pharmacogenetics of Alcohol: Treatment Implications
Alcohol Related Disorders · Alcoholism · Alcohol Abuse
Primary: Breath Alcohol — 0.001; 0.075; 0.001; 0.071 gr/dL — p=0.28
N/A N=44 Satiety and Alcohol Challenge
Alcohol Drinking
Primary: Change in Alcohol Specific Satiety Score — -0.51; 4.85 score on a scale
N/A N=33 Alcohol Biosensor Monitoring for Alcoholic Liver Disease
Alcohol Use, Unspecified
Primary: Alcohol Use — 7.4; 5.3; 4.4 drinks per episode
Early Phase 1 N=30 Behavior Brain Responses
Alcohol Drinking · Drinking Behavior · Physiological Effects of Drugs
Primary: Change in Subjective Effects as Assessed by Score on "Feel Drug", "Feel High", "Like Drug", and "Want More" Subscales of the Drug Effects Questionnaire Across Sessions…
N/A N=180 Intravenous Alcohol Administration Using BrAc Method in Healthy Subjects With and Without a Family History of Alcoholism
Alcoholism
Primary: Number of Drinks Felt Consumed at Baseline — 0; 0; 0; 0 drinks felt consumed
N/A N=38 Alcohol and Neural Cardiovascular Control in Binge Drinkers
Binge Drinking
Primary: Sympathetic Nerve Activity Burst Frequency — 18; 20 Burst/Min — p=0.283
Phase 4 N=43 Endophenotype for Alcohol Misuse in Healthy Minority Populations
Healthy
Primary: Biphasic Alcohol Effects Scale - Stimulation — 11.3; 3.9; 8.7; 3.2 units on a scale
Phase 1 N=34 Mavoglurant in Alcohol Drinking
Alcohol Drinking
Primary: Abnormal Labs and Adverse Events — 9; 8; 0; 0 Participants
N/A N=28 Sex Differences in Risk for Alcohol Abuse
Alcohol Abuse
Primary: Brain Activation During Response Inhibition (BARI) - Alcohol Infusion — 1.83; 2.41 BOLD activation
N/A N=73 GABA Mechanisms Underlying the Vulnerability to Alcohol Dependence
Alcoholism
Primary: Visual Analog Scales of Similarity to Alcohol - Baseline — 0; 0; 0; 0 units on a scale
Phase 1 N=5 Investigating the Interactions of AZD0530 With Alcohol in Social Drinkers
Alcohol Drinking
Primary: Safety/Tolerability of Study Medication. — 0 participants
Phase 4 N=15 Effect of Ethanol Intoxication on the Anti-Hypoglycemic Action of Glucagon
Type 1 Diabetes Mellitus
Primary: AOCGIR (Area Over the Curve for Glucose Infusion Rate) — 1996; 1981 mg*minute/dl
Phase 1 N=93 Differential Responses to Drugs and Sweet Tastes
Bipolar II Disorder
Primary: Change in Subjective Effects as Assessed by Score on "Feel Drug", "Feel High", "Like Drug", and "Want More" Sub-scales of Drug Effects Questionnaire (DEQ). — 18.88…
N/A N=125 Characterizing the Effects of Family History of Alcoholism on Alcohol Analgesia
Effects of Family History of Alcoholism and Sex on Alcohol Analgesia
Primary: Heat Pain Threshold — 43.56; 43.63; 42.28; 43.94 degrees celsius — p=.92
N/A N=60 Acute Alcohol Response In Bipolar Disorder: a fMRI Study
Bipolar Disorder · Alcohol Drinking · Alcohol Use Disorder
Primary: Level of Intoxication (Subjective Response) on Each Condition Day After Drinking Relative to How They Felt When Arriving to the Lab on That Respective Day )Prior to…
N/A N=16 Effects of Alcoholic Beverages in Pro-inflammatory and Antioxidant Profile After an Oral Fat Diet
Alcohol Consumption
Primary: Change From Baseline in Concentrations of Antioxidant Profile After Red Wine Intake — 22.3; 12.7 percentage of change in TAC — p=0.05
Phase 2 N=80 Sweet Preference and Alcohol Craving
Alcohol Dependence · Alcohol Abuse
Primary: Percent Heavy Drinking Days — 0.63; 0.14; 0.09; 0.17 percentage of days
N/A N=9 Genetic and Neural Factors in Alcohol-Related Cognition
Alcohol Abuse
Primary: Changes in Alcohol-influenced Behavior — 1.56; 1.49 units on a scale
Phase 2 N=109 Moderate Alcohol Intake Among Patients With Type 2 Diabetes
Type 2 Diabetes
Primary: Glucose — -21.55; 1.92 mg/dL
Phase 2 N=13 Effect of Endotoxin on Alcohol Consumption
Alcohol Use Disorder
Primary: Alcohol Consumption — 37.57; 50.08 Milliliters
N/A N=30 Effect of Heavy Alcohol Consumption on Farnesoid X Receptor (FXR) Signaling
Alcohol Consumption
Primary: Change in Bile Salt Metabolism (C4 )Levels to Determine Effect of FXR
N/A N=13 Effects of Sulfasalazine on BOLD Response to Alcohol Cues
Alcohol Dependence
Primary: % BOLD Response Increase Above Baseline — .106; .082; .074; .097 % BOLD Response increase above baseline — p==.05
Phase 2 N=44 Effect of Varenicline on Fixed-Dose Alcohol Administration in Participants With Alcohol Use Disorders
Alcohol Reactivity
Primary: Cognitive Function as Measured by Omissions on the CPT — 1.78; 1.28; 4.76; 0.98 Number of Omissions
Early Phase 1 N=8 Imaging Glutamate Release From Alcohol
Alcohol Drinking
Primary: Alcohol-induced Change in Receptor Availability — -9.1 percentage change of BP_ND
Early Phase 1 N=80 Alcohol, Behavior, and Brain Imaging
Alcohol Drinking · Binge Drinking · Drinking Behavior
Primary: Stop Signal Task (SST) — 255; 215 milliseconds
N/A N=48 Acute Effects of Alcohol Use on Chronic Orofacial Pain
Temporomandibular Joint Disorders
Primary: Pressure Pain Threshold — 4.56; 5.27; 3.81; 4.51 lbf — p=.99
N/A N=12 The Effects of Alcohol Consumption on Central Adiposity
Alcohol Drinking · Weight Loss · Adiposity
Primary: Change in Central (Abdominal) Adiposity — -0.250; -0.071 kg — p=<0.231