N/A N=16 Modulation of Emotion Perception in Humans Via Amygdala Stimulation
Refractory Epilepsy
Primary: Z-score Gamma Power in Amygdala Per Valence Category — 1.21; 1.88; 1.24 z-score
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=36 Effect of Amygdala Neurofeedback on Depressive Symptoms and Processing Biases
Major Depressive Disorder
Primary: Change From Baseline in Montgomery Asberg Depression Rating Scale at 2 Weeks — 23.5; 23.8; 11.9; 21.9 units on a scale — p=<0.001
N/A N=18 Effects of Connectivity-based rTMS and State-Dependency on Amygdala Activation
Amygdala Activation
Primary: Acute Effect of a rTMS Session on Brain Activation as Measured by the Cerebral Blood Flow (Blood Oxygenation Level Dependent Signal) — 0.67; -0.48 z score in the…
Phase 2 N=138 Neural Substrates of Emotion: Impact of Cocaine Dependence
Cocaine Use Disorder
Primary: Functional Connectivity Between Corticolimbic Brain Regions During Acute Social Stress — .011; .012; .043; .0008 Arbitrary units
N/A N=1,063 Brain Imaging Changes in Fear and Anxiety
Anxiety Disorders · Fear
Primary: Average Correlations Between Average Time Series - Left & Right Hemisphere of the Brain — 0.9; 0.92 correlation coefficient (r) — p=< 0.001
N/A N=94 Approach-Avoidance Conflict-a Multi-level Predictor for Therapy Response
Generalized Anxiety Disorder
Primary: For Aim1: Baseline Generalized Anxiety Disorder Symptoms as Measured by the Generalized Anxiety Disorder - 7 Item Scale (GAD-7). — 12.85; 11.62 units on a scale — p=.088
Phase 1 N=21 Brain Dynamics of Oxytocin
Brain Dynamics in Healthy Adults
Primary: Number of Benevolent Rounds — 6.8; 6.8 number of rounds
N/A N=62 Examining Brain Responses Linked to Emotion in Individuals Who Smoke Cigarettes
Smoking, Tobacco
Primary: Brain Activation During Smoking-related and Neutral Cues — 5.8; -1.6; 1.1; -4.2 contrast of parameter estimate — p=0.13
N/A N=19 Activating and Identifying Neural Responses to Social Rejection: a Combined tDCS and fMRI Study
Healthy
Primary: Blood Oxygen Level Dependent (BOLD) Signal Changes (in Arbitrary Units) — .57; .66; .25; .29 Arbitrary units
N/A N=1,418 Effects of Arousal and Stress in Anxiety
Healthy Volunteers
Primary: Go Correct Hits Followed by Button Press — 90.9; 91.6 Percentage of correct responses
N/A N=214 Brain Response Associated With Parent-based Treatment for Childhood Anxiety Disorders
Anxiety Disorder of Childhood · Separation Anxiety Disorder of Childhood · Social Anxiety Disorder of Childhood
Primary: Change From Baseline Anxiety Severity on the Pediatric Anxiety Rating Scale (PARS) at Week 12. — -11.82; -6.29; -8.47; -6.54 score on a scale
N/A N=99 fMRI Studies of Emotional Brain Circuitry in People With Major Depression
Depression
Primary: Activations in Different Cortical Regions Caused by Emotionally Evocative Task — -0.021; 0.084; 0.021; -0.030 Voxels
N/A N=21 Neurofeedback Enhanced Cognitive Reappraisal Training
Anxiety · Social Anxiety Disorder · Panic Disorder
Primary: Change in Prefrontal Cortex (PFC) Activity (Baseline to Transfer Run) From the Reappraise > Look Contrast on the Emotion Regulation Task (ERT) — 0.042; 0.019; 0.007…
N/A N=15 Assessing Visual Processing in High Anxiety
Anxiety
Primary: Tolerability of the Micro Expression Training Task in Individuals With High Anxiety — 5; 6 Participants
N/A N=99 Investigating the Neural Systems That Support the Beneficial Effects of Positive Emotion on Stress Regulation
Behavior
Primary: Mood Ratings (Pos) — 1.34; 1.04; .96; .83 units on a scale
Phase 3 N=22 Study of Ibuprofen Effects on Brain Function
Major Depressive Disorder
Primary: Dose-dependent Differences in the BOLD Response to fMRI Tasks in the Amygdala — 0.20; 0.21; 0.23; 0.23 percent signal change — p=0.512
N/A N=163 Effect of Emotion Mindsets on Emotion Processing
Emotions
Primary: Mean Change From Pre to Post Mindset Manipulation on Emotion Mindset Scale (Measures Beliefs About Whether Emotions Are Fixed or Malleable) — 3.03; 3.03; 2.17; 2.76…
N/A N=46 Morning Light Treatment for Traumatic Stress: The Role of Amygdala Reactivity
Stress
Primary: Change in Amygdala Reactivity as Measured by Blood-oxygen-level-dependent (BOLD) Functional Magnetic Resonance Imaging (fMRI) Signal — 0.1287; 0.1532; 0.2134; 0.1048…
N/A N=206 Targeting Attention Orienting to Social Threat to Reduce Social Anxiety in Youth
Social Anxiety Disorder of Childhood
Primary: P1 Amplitude Elicited in the Dot-probe Task — 7.04; 5.61 microvolts
Phase 2 N=23 Characterizing the Neural Substrates of Irritability in Women: an Experimental Neuroendocrine Model
Perinatal Depression · Post Partum Depression · Depression, Postpartum
Primary: Mean Threat Processing Bias During Visual Dot-probe Paradigm Over Time — -0.57; 36.92; -9.04; -42.35 attention bias in milliseconds — p=0.160
Early Phase 1 N=80 Alcohol, Behavior, and Brain Imaging
Alcohol Drinking · Binge Drinking · Drinking Behavior
Primary: Stop Signal Task (SST) — 255; 215 milliseconds
N/A N=15 Adolescent Attention to Emotion Study
Depression
Primary: Affect-biased Attention Following Neurofeedback (Immediately Post-Intervention) — .41 Proportion (0-1) — p=.004
N/A N=40 Stimulating the Social Brain
Healthy Adults
Primary: Change in General Paranoid Ideation for Active vs. Sham Simulation — 1.60; .73 score on a scale
Early Phase 1 N=26 Intranasal Oxytocin Administration and the Neural Correlates of Social and Non-Social Visual Perception
Social Perception
Primary: Amplitude Social — -3.72; -3.55; -3.28; -3.30 microvolts — p=.003
N/A N=29 Positive Valence System Enhancement Treatment for Anxiety and Depression: Clinical Efficacy and Neural Changes
Anxiety Disorders and Symptoms · Depression
Primary: Change From Baseline in Positive Affect (Positive and Negative Affect Schedule; Modified Differential Emotions Scale; Composite) — -0.41; -0.40; 0.73; -0.02 z-score
N/A N=50 Brain Imaging Techniques That Predict Antidepressant Responsiveness
Major Depressive Disorder
Primary: Hamilton Depression (HAM-D) and Anxiety (HAM-A) Rating Scales — 20.07; 21.36; 1; 14.07 units on a scale
Phase 4 N=67 Comparison of the Effects of Aripiprazole and Risperidone on the Pattern of Brain Activation in Schizophrenic Patients
Schizophrenia, Undifferentiated Type
Primary: Identification of Brain Circuits Involved in a Task of Emotional Congruence (With fMRI) — -0.25; -0.21; 3.8; 0.2 arbitrary units of activation
N/A N=131 Neurobiological Responses in Alcoholism and Early Trauma
Alcohol Use Disorder · Early Trauma Complications
Primary: Brain Response — .015; .010; -.013; .08 unitless — p=<0.05
N/A N=84 The Effect of Prefrontal Cortex Stimulation on Antisocial and Aggressive Behavior
Antisocial Behavior · Aggression
Primary: Change in Antisocial Behavior Inclinations at 24 Hours — 1.41; 3.05 score on a scale
Phase 4 N=32 Drug Treatment Validation of Functional Magnetic Resonance Imaging in Generalized Anxiety Disorder
Generalized Anxiety Disorder
Primary: Signal Change in Brain Activity in the Amygdala When Viewing Emotional Faces — .1489; .1074; .0119; .1404 Percent signal change in brain acitivity