Clinical Trial Search

Primary: Crude Incidence Rate of Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Per 1000 Person-years by Age — 0.01; 0.01; 0.03; 0.12 incidence rate per 1000 person-years

Primary: Change in Visual Acuity — 4; 3 lines change in Snellen chart

Primary: Change From Baseline in Visual Acuity at 9 Month — -0.0574; 0.0535 LogMAR

Primary: Mean Increase From Baseline in ETDRS Letters Read at 26 Weeks and Off-drug Follow-up Visit — 15; 7; 9; 6 EDTRS Letters

Primary: Change in Full-field Visual Evoked Potential (FF-VEP) Latency at Week 24: Intent-to-treat (ITT) Population — 20.83; 17.34 msec — p=0.3337

Primary: Retinal Nerve Fiber Layer Thickness at Baseline and Month 6 — 128.1; 130.5; 89.5; 88.0 µm

Primary: Number of Participants With Change/Improvement Visual Acuity From the Beseline — 28; 3; 5 Participants

Primary: Radical Peripapillary Capillaries Vessel Density — 55.95; 57.24 percentage of vessel

Primary: Percentage of Patients With a Visual Field Improvement in the Study Eye — 12.0; 9.5; 4.2 Percentage of Patients

Primary: Right Intraocular Pressure During Various Event Intervals in Open Abdominal Aortic Aneurysm Surgery. — 16.9; 13.8; 14.6; 13.5 mm Hg — p=<0.001

Primary: 30-Day Person Time Analysis Risk of NAION Associated With PDE5 Inhibitor Use — 2.27 Relative risk of exposure

Primary: Detection Accuracy (DA) Change in Percent Over Baseline Within Defective Visual Field Sectors — 24.75; 39.16 percent change

Primary: Number of Days Exposed to PDE5i During 1-Day Case Window and 29 1-Day Control Windows Among Participants Adjudicated as Definite NAION Cases — 14; 248 exposed days…

Primary: Changes in Vessel Density in Treatment Groups Assessed by OCT Angiography — -0.51; 2.59; -0.96; 0.96 percent change

Primary: Lamina Cribrosa (Boundaries of the Retinal Layers) Measurements — 264.3; 273.3; 276.2 micro-ohms

Primary: Number of Participants With Detected Relative Afferent Pupillary Defect (RAPD) — 44; 37 participants

Primary: Area of Lesion Measured by Optical Coherence Tomography Angiography (OCTA) Scan. — 1.07 mm^2

Primary: Retinal Ganglion Cell Inner Plexiform Layer Thickness — 36.56; 34.65; 31; 29.42 micron

Primary: Blood Oxygenation — 60; 60; 60 percentage of oxygenation

Primary: Blood Oxygenation at the Optic Nerve Head — 60.8; 65.3 percentage of oxygen saturation

Primary: The Change in Best-corrected Visual Acuity (BCVA) From Baseline to Year 2 for All Participants. — 0.2; -11.3 ETDRS Letters

Primary: Presence of Retinal Vascular Dysregulation (RVD) — 7; 4 Participants

Primary: Reduction in Macular Edema — 15; 8; 4 Participants

Primary: Incidence of Adverse Events — 3; 4 Participants

Primary: Visual Acuity at Distance (6m) logMAR — 0.00; -0.02; 0.02; 0.00 logMAR

Primary: Change in Superior Retinal Capillary Blood Flow (% Zero Pixels) — -0.026; 0.011 % zero pixels — p=0.0016

Primary: Change in Intraoperative Ocular Pressure in Lumbar Spine Fusion Patients Head Raised 10 Degrees or Kept in Neutral Position — 9.26; 13.79 mm Hg

Primary: Corneal Thickness — 542.23; 546.16; 544.32 microns

Primary: Changes in ONSD in mm With Changes in ICP in Healthy Volunteers. — 4.2 mm

Primary: Volume of New FLAIR Lesions(MRI) — 915; 477 mm^3 — p=0.445