Phase 4 N=204 Reinfusion Drains vs Tranexamic Acid in Total Joint Arthroplasty
Total Joint Arthroplasty
Primary: Blood Transfusion — 5; 8; 1 participants
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Phase 2 N=101 Topical Tranexamic Acid and Acute Blood Loss in Total Knee Arthroplasty
Acute Blood Loss Anemia · Osteoarthritis, Knee
Primary: Blood Loss — 1293.1; 940.2 mL
Phase 3 N=40 Blood Loss Reduction After Total Knee Arthroplasty. Comparison Topical Tranexamic Acid vs Platelet Rich Plasma
Osteoarthritis
Primary: Therapeutic Effect on Hemoglobin Level — 13.6; 13.6; 10.3; 9.9 g/dL
N/A N=90 Low Dose Peri- Operative Intra Venous Teranexamic Acid Reduces Blood Loss After Total Knee Arthroplasty: A Double Blind Randomized Placebo Controlled Clinical Trial
Knee Arthroplasty, Total
Primary: Hb Level 48 Hours After Total Knee Arthroplasty — 10.92; 10.23 gr/dL
N/A N=35 The Effect of Hypotensive Anesthesia on Hemoglobin Levels During Total Knee Arthroplasty
Anesthesia
Primary: The Hemoglobin (in g/dl) Levels — 12.2; 12.0; 11.9; 11.8 g/dl
Phase 4 N=188 Topical Tranexamic Acid (TXA) in Joint Arthroplasty
Osteoarthritis · Hip Arthropathy · Shoulder Arthropathy
Primary: Post-operative Blood Loss — 1,062.88; 1,204.60; 933.92 mL
Phase 2 N=21 Tranexamic Acid Dosing for Major Joint Replacement Surgery
Arthroplasty, Replacement, Knee · Arthroplasty, Replacement, Hip
Primary: Blood Plasma TXA Concentration - Total Body Clearance — 58.0; 116 mL/min
N/A N=89 Efficacy of Tranexamic Acid for Reducing Blood Loss and Blood Transfusion After Periacetabular Osteotomy
Dysplasia, Congenital Hip
Primary: Calculated Total Blood Loss — 1264.6; 1515.4 mL
Phase 4 N=60 Efficacy of Preoperative Autologous Blood Donation and Tranexamic Acid in Revision Total Hip Arthroplasty
Revision Total Hip Arthroplasty (RTHA)
Primary: Number of Transfused Allogeneic Blood Units (in Digits). — 2.0; 0.0 units
Phase 3 N=65 Weighted Versus Uniform Dose of Tranexamic Acid in Patients Undergoing Primary, Knee Arthroplasty
Osteoarthritis · Intraoperative Bleeding
Primary: Primary Intra-operative Blood Loss — 100.00; 65.00; 142.80; 100.00 mL
N/A N=111 Unipolar vs. Bipolar Hemostasis in Total Knee Arthroplasty: A Prospective Randomized Trial
Knee Arthroplasty
Primary: Drain Output. — 776; 778 mL
Phase 4 N=84 Tranexamic Acid Dosing for Total Joint Arthroplasty
Arthropathy of Hip · Arthropathy of Knee
Primary: Change in Hemoglobin From Baseline to the First Post-operative Day (POD#1) — 2.15; 2.06; 2.11 g/dl
Phase 1 N=61 Arista Hemostatic Powder for Total Knee Post Operative Outcomes Study
Blood Loss, Surgical
Primary: Blood Loss — 122.6; 133.3 cubic centimeters
N/A N=14 Blood Volume Analysis of Total Hip Arthroplasty Patients Under Hypotensive Anesthesia
Blood Volume Analysis
Primary: Change in Total Blood Volume — 487 ml
Phase 3 N=87 The Use of Tranexamic Acid to Reduce Blood Loss in Acetabular Surgery
Acetabular Fractures
Primary: Allogenic Blood Transfusion Rates — 21; 13 Participants
N/A N=135 Efficacy of Low-dose Intra-articular Tranexamic Acid in Total Knee Replacement
Primary Osteoarthritis of Knee Nos
Primary: Perioperative Blood Loss — 546.9; 475.0; 430.2; 329.2 ml — p=<0.05
Phase 4 N=140 Evaluation of the Efficacy of the Bipolar Sealer Aquamantys 6.0 in Patients Undergoing Total Hip Arthroplasty
Hip Arthritis
Primary: Number of Patients Managed With Blood Transfusion — 15; 14 participants
Phase 4 N=246 TXA vs. Amicar in Total Knee and Hip Arthroplasty
Blood Loss · Hip Arthritis · Knee Arthritis
Primary: Total Blood Loss Over Course of Stay (Intraoperative and Postoperatively Until Discharge) — 934.1; 948.7; 660.6; 891.2 milliliters — p=<0.05
Phase 4 N=640 Randomized Controlled Trial of Tranexamic Acid in Total Knee Arthroplasty: Intravenous vs. Topical
Osteoarthritis
Primary: Total Blood Loss — 323.59; 271.22 ml
Phase 4 N=100 Prospective Evaluation of Vitagel for Reduction in Blood Loss and Pain Following Unilateral Total Knee Arthroplasty
Arthritis
Primary: Number of Patients Managed With Blood Transfusion — 0; 5 participants
Phase 3 N=52 Use of a Novel Fibrin Sealant in Total Knee Arthroplasty
Osteoarthritis · Intraoperative Bleeding
Primary: Primary--Percent Change of Pre- to Post-Operative Hemoglobin — 20.1; 22.5 Percent Change — p=0.2
N/A N=26 Serum Levels of Bupivacaine in Autotransfusion Drains Following Total Joint Arthroplasty
Knee Pain Arthritis
Primary: Change in Blood Serum Levels of Bupivocaine From Baseline — 0.6; 0.95; 0.8 ug/cc
Phase 4 N=82 Study Of Tranexamic Acid For The Reduction Of Blood Loss In Patients Undergoing Surgery For Long Bone Fracture
Femoral Fractures
Primary: Total Blood Loss — 370.7; 426.2 Milliliters (mL) — p=0.348
N/A N=150 Traditional vs Oral Fluid Management in Total Knee Arthroplasty
Arthroplasty, Replacement, Knee
Primary: Body Weight — -1.9; -1.6 pounds
Phase 4 N=150 Tranexamic Acid in Knee Joint Surgery
Osteoarthritis
Primary: Blood Loss — 1090; 716; 746 mls — p=<0.05
Phase 4 N=196 The Use of FLOSEAL to Reduce Bleeding in Total Knee Replacement Surgery
Blood Loss
Primary: Change in Hemoglobin on Day 0 Compared to Preoperatively — -1.277; -1.241 g/dL
Phase 4 N=36 Topical (Intra-Articular) Tranexamic Acid and Transfusion Rates Following Hip Hemiarthroplasty
Femoral Neck Fractures
Primary: Number of Participants Who Needed Transfusions — 0; 5 Participants
N/A N=11,292 Outcomes After Hypotensive Neuraxial Anesthesia in Total Hip Arthroplasty
Total Hip Arthroplasty · Primary Total Hip Arthroplasty · Hypotension
Primary: Number of Participants Who Experience Myocardial Infarction, Cerebrovascular Accident, or Mortality — 16; 2; 0; 3 Participants
N/A N=106 Accuracy of Blood Loss Estimation After Vaginal Delivery
Postpartum Hemorrhage
Primary: Difference in Actual Blood Volume and Estimated Blood Volume in Milliliters. — -20.8; -41.7; -53.5; -96.0 milliliters — p=<0.05
Phase 4 N=400 Oral Versus Intravenous Tranexamic Acid
Blood Loss · Blood Transfusion
Primary: Calculated Blood Loss — 842; 860; 799; 878 CBL (ml)