Phase 2 N=65 A 10-week Efficacy Study of NOE-105 in Childhood Onset Fluency Disorder (Orpheus)
Childhood-Onset Fluency Disorder
Primary: Change From Baseline to End of 6 Weeks in Total MLGSSS — -7.0; -5.5 Score on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=19 Manipulating Linguistic Complexity to Improve Child Language Treatment Outcomes
Language Development Disorders · Speech Sound Disorder
Primary: Treatment Probe Accuracy Change — 26; 23 percent accuracy of target consonants
N/A N=28 Retrieval-Based Word Learning in Developmental Language Disorder
Developmental Language Disorder · Specific Language Impairment · Language Development
Primary: Word Form Recall Accuracy (Number of Words Correctly Recalled) on Expanding and Standard Retrieval Schedules at 5 Mins — 3.93; 6.43; 3.71; 5.21 number of words recalled…
N/A N=27 Retrieval-Based Word Learning in Developmental Language Disorder During Book Reading
Developmental Language Disorder · Specific Language Impairment · Language Development
Primary: Word Form Accuracy (Number of Words Correctly Recalled) in Repeated Spaced Retrieval (RSR) and Repeated Study (RS) Conditions at 5 Mins. — 4.54; 6.5; 1.46; 4.0 number of…
N/A N=90 Treatment of Social Anxiety Disorder and Selective Mutism
Social Anxiety Disorder · Selective Mutism
Primary: Change in Clinical Severity Ratings (CSR) of SAD & SM on the Anxiety Disorders Interview Schedule - Parent Version (ADIS-P) — -1.26; -1.65; -1.51; -1.24 units on a scale…
Phase 1 N=14 Delineation of Sensorimotor Subtypes Underlying Residual Speech Errors
Speech Sound Disorder
Primary: Normalized F3-F2 Distance, an Acoustic Measure That Correlates With Perceptual Accuracy of /r/, Measured From /r/ Sounds Produced in Treatment Sessions. — 5.73; 6.27…
N/A N=36 Bihemispheric Transcranial Direct Current Stimulation* on Speech Fluency
Stuttering, Adult
Primary: Stuttered Syllables in Passage Reading (Change in the Percentage of Stuttered Syllables After 5 Days of Intervention From Baseline) — -1.41; -0.81 percentage of…
N/A N=56 Treating Childhood Apraxia of Speech
Childhood Apraxia of Speech
Primary: Speech Sound Accuracy — 54.1; 32.5; 26.8; 42.1 Percent correct — p=.132
Phase 1 N=39 ASSIST: Treatment for Childhood Apraxia of Speech
Childhood Apraxia of Speech
Primary: Speech Accuracy of Treated Items — -0.7; 10.6; -2.8; -1.4 percentage of accuracy (change score) — p=0.0001
N/A N=31 Retrieval-Based Word Learning in Developmental Language Disorder: Verb Learning
Developmental Language Disorder · Specific Language Impairment · Language Development
Primary: Verb Recall Accuracy (Number of Verbs Correctly Recalled) in Repeated Spaced Retrieval (RSR) and Repeated Study (RS) Conditions at 5 Mins. for Learned Items — 3.79…
N/A N=18 Predictors of Speech Ability in Down Syndrome
Speech Intelligibility Intervention in Down Syndrome
Primary: Speech Intelligibility — 3.59 score on a scale
N/A N=108 Correcting Residual Errors With Spectral, Ultrasound, Traditional Speech Therapy
Speech Sound Disorder
Primary: Change in F3-F2 Distance (Hz) Across Sessions, Measured From /r/ Sounds Produced in Syllables or Words During Practice. — 38.2; 66.7; 85.2 Hertz / session — p=< .0001
Phase 4 N=43 Fluoxetine in Pediatric Body Dysmorphic Disorder
Body Dysmorphic Disorder
Primary: Change in Total Score on the BDD-Y-BOCS Scale — -12.27; -9.53 units on a scale
N/A N=48 Kindergarten Children Acquiring Words Through Storybook Reading
Language Development Disorders
Primary: Change in Definition Scores From Pre- to 12-weeks Post-treatment — 2.50; 3.18; 5.50 number of words
N/A N=7 What Treatment Works for Children With Selective Mutism?
Selective Mutism
Primary: School Speech Questionnaire (SSQ) — 2.68 Units on a scale — p=<0.001
N/A N=24 Training Grammar With Meaning
Language Disorders in Children
Primary: Change in the Use of Treated Grammatical Forms in Untreated Contexts — 6.6; 5.8 Generalization d
Phase 2 N=18 Early Intervention With Fluoxetine in Autism
Autistic Disorder
Primary: Rate of Recruitment — 2.1; 2.1 months/participant at 1 site
Phase 2 N=110 AFQ056 for Language Learning in Children With FXS
Fragile X Syndrome
Primary: Change in Weighted Child Intentional Communication Score — 0.14; 0.04 log10(scores on a scale) — p=0.1587
N/A N=112 Semantic Learning Deficits in School Age Children With Developmental Language Disorder
Developmental Language Disorder
Primary: Mean Percent Correct Semantic Meaning Identification — 73.6; 75.12; 77.1; 82.3 percentage of correct responses — p=0.36
Phase 2 N=34 Characterization and Sequential Pharmacotherapy of Severe Mood Dysregulation
Severe Mood Dysregulation
Primary: Clinical Global Impression-Severity-Severe Mood Dysregulation — 4.91; 3.62; 4.30; 4.42 units on a scale — p=.58
N/A N=30 Penetrating the Classroom Social Network for Children With Language Impairment Via Peer Mediated Intervention
Peer Influence
Primary: Preschool Language Screener 5 (PLS-5) - Growth Scale Value — 437.09; 455.38; 459.09; 464.77 score on a scale — p=.84
Phase 2 N=31 Videophone Administered Cognitive-Behavioral Therapy for Pediatric Obsessive-Compulsive Disorder
Obsessive Compulsive Disorder
Primary: Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS; Scahill et al., 1997). The CY-BOCS is a 10-item Semi-structured Measure of Obsession and Compulsion Severity…
N/A N=225 Fronto-temporal tDCS Mproves Fluency & Empathy in ASD Kids
Autism · ASD
Primary: Verbal Fluency — 9.3; 10.5; 9.9; 8.3 units on a scale
N/A N=24 New Therapeutical Perspectives in Cases of Phonological Disorders
Speech Sound Disorders
Primary: Percentage of Consonants Correct (PCC) Pre-treatment and Post-treatment Phonological Instrument — 70.63; 68.13; 75.5; 79.88 PCC - (%) — p=0.001
Phase 2 N=30 D-Cycloserine Augmentation of Therapy for Pediatric Obsessive-Compulsive Disorder
Obsessive-compulsive Disorder
Primary: Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS; Scahill et al., 1997). — 26; 24.1; 17.9; 15.6 units on a scale — p=<0.05
N/A N=40 Family-Based Prevention Program for Childhood Anxiety
Anxiety Disorders
Primary: Number of Children With Child Anxiety Diagnosis — 20; 20 participants
N/A N=144 Sequential Treatment of Pediatric MDD to Increase Remission and Prevent Relapse
Depression
Primary: Time to Remission — 13.67; 11.33 weeks
N/A N=21 Proof of Concept Study of an Oral Orthotic to Reduce Tic Severity in Chronic Tic Disorder and Tourette Syndrome
Tourette Syndrome · Chronic Tic Disorder
Primary: Change in Global Severity of Tics and Clinical Condition as Measured by YGTSS — 20.19; 25.82 score on a scale
Phase 3 N=45 Cognitive-Behavioral Treatment for Anxiety Disorders in Children With Autism Spectrum Disorders
Autism · Asperger's Syndrome · Generalized Anxiety Disorder
Primary: Pediatric Anxiety Rating Scale (Measures the Severity of Anxiety Symptoms) — 16.33; 17.62; 11.58; 16.05 units on a scale
Phase 3 N=38 A Phase 3 Study of Fluvoxamine (SME3110) in Pediatric/Adolescent Patients With Obsessive Compulsive Disorder
Obsessive Compulsive Disorder
Primary: Mean Change From Baseline in the Japanese Children's Yale-Brown Obsessive Compulsive Scale 10-item Total Score at the End of Treatment in the First Phase — -10.5; -6.6…