Phase 2 N=30 Evaluation 2% Chlorhexidine Gluconate
Skin Coverage
Primary: Medline 2% CHG Cloth Dosage of Coverage Area — 0.0081 g/cm^2
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=163 Use of 2% Chlorhexidine Cloths Reduce Surgical Site Infections
Surgical Site Infection
Primary: Incidence of Surgical Site Infections — 0; 0 Participants
Phase 3 N=554 Preoperative Chlorhexidine Gluconate (CHG) Cloth on Healthy Subjects
Surgery
Primary: Percent Responder Rates (%) of Bacterial Reduction on the Abdomen and Groin — 93; 86; 50; 25 Percent of Sites
Phase 3 N=621 Preoperative Chlorhexidine Gluconate (CHG) Cloth on Healthy Volunteers
Surgery
Primary: Responder Rates (%) of Sites Identified for Bacterial Reduction on the Abdomen and Groin — 78; 84; 54; 56 Percent of sites
N/A N=100 Pre-operative Preparation Using 2% Chlorhexidine Cloth For Shoulder Surgery
Post-operative Surgical Site Infections
Primary: Number of Patients With a Clinically Diagnosed Infection — 0; 0 participants
Phase 2 N=50 A Double-blind Randomized Placebo Controlled Clinical Trial Evaluating Effect of Chlorhexidine Gluconate 2% Cloth vs Placebo Cloth Baths on the Incidence of Central Line-Associated Blood Stream Infections in Outpatient Hematopoietic Stem Cell Transplant Patients
Stem Cell Transplant Complications
Primary: Number of Participants With Primary Blood Stream Infections — 1; 2 Participants
Phase 3 N=39 Irritation and Sensitization of Chlorhexidine Gluconate (CHG) Cloth
Surgery
Primary: Grading Scale for Visual Evaluation of Skin Condition — 0; 0; 0; 0 Scores Ranging (0-7)
Phase 3 N=1,388 Preoperative CHG Cloth on Healthy Subjects
Surgery
Primary: Percent Responder Rates of Bacterial Reduction on the Abdomen and Groin Sites — 80; 75; 86; 65 % of Treated Sites
N/A N=66 Chlorhexidine Gluconate Oral Care for Adults Experiencing Trauma
Ventilator Associated Pneumonia
Primary: Effectiveness of Chlorhexidine Gluconate Oral Care for Trauma Patients — 30; 29 participants
Phase 3 N=2,518 Study of Bathing With Chlorhexidine Impregnated Cloths on Nosocomial Infections in the Pediatric Intensive Care Unit
Nosocomial Infections
Primary: Bacteremia — 3.52; 4.93 events per 1000 at-risk days
Phase 3 N=157 2% Chlorhexidine Gluconate Skin Cloths to Prevent SSI in Spine Surgery Patients
Surgical Site Infections · Post Operative Complication
Primary: Participants With Surgical Site Infection Development at 30 Days Post-operative — 5; 5 Participants — p=0.456
Phase 2 N=126 Antimicrobial Efficacy of 2% CHG (Chlorhexidine Gluconate)
Healthy
Primary: Log Reduction of Bacterial Flora on the Abdomen and Groin — 1.9; 2.0; 1.3; 1.9 Log10 Reductions
Phase 4 N=134 Tolerance of Chlorhexidine Gluconate Vaginal Cleansing Solution
Surgical Preparation of the Vagina
Primary: Number of Participants With Vaginal or Urinary Symptoms After Surgery, Assessed by Validated Questionnaire (Modified PRO-CTCAE) — 4; 11; 8; 25 Participants
Phase 2 N=52 Pilot Trial of Chlorhexidine Gluconate (CHG) Preoperative Skin Preparation
Surgery
Primary: Log Change in Bacterial Flora on Abdomen and Groin — 2.9; 3.7; 2.3; 3.0 Log (CFU)
N/A N=40 The Value of Home Chlorhexidine Pre-Surgical Wash Before Spine Surgery
Infection · Spinal Injuries
Primary: Number of Patients With Cutaneous Bacterial Load After Surgery — 0; 18; 21; 1 Participants — p=<0.05
Phase 2 N=276 In Vivo Preoperative Skin Preparation Persistence Evaluation
Bacterial Recovery of Skin Flora Post-product Application
Primary: Measurement of Skin Flora Recovery Post-prep Application — 1.39; 1.15; 1.97; 1.82 log10 CFU/cm^2 — p=0.13
Phase 4 N=38 Antimicrobial Agent for Reducing Bacteria in Aerosols and Oral Cavity
Dental Prophylaxis and Implant Surgery
Primary: Total Number of Detectable Plaque Bacteria Sampled 3 Days Post Implant Surgery — 7.63; 7.43 log(10) colony forming equivalents (CFE) — p=0.2965
N/A N=53 Chlorhexidine Dressings for Hemodialysis Catheter Exit Site Care: Comparative Study
Hemodialysis Catheter Infection
Primary: Bacteraemia Rate — 2; 1 episodes — p=1.00
Phase 4 N=324 An Efficacy Study of Chlorhexidine Mouthwashes
Gingivitis
Primary: Gingival Severity Index (GSI) Based on the Gingival Index (GI) — 0.152; 0.143; 0.212 Units on a scale — p=<0.0001
Phase 2 N=108 Pilot Trial of Preoperative Chlorhexidine Gluconate (CHG) Skin Preparation
Surgery
Primary: Log Reduction of Bacterial Flora on Abdomen and Groin Sites — 2.6; 3.4; 2.7; 4.2 Log 10 Reduction
Phase 3 N=68 Clinical Performance of a Chlorhexidine Antimicrobial Dressing
Catheterization
Primary: Clinician Overall Satisfaction With Catheter Securement — 2.27; 1.63 Units on a scale
N/A N=60 Safety of Skin Cleansing With Chlorhexidine in Preterm Low Birth Weight Infants
Neonatal Sepsis · Low Birth Weight
Primary: Median Skin Condition Score on the 9-point Skin Condition Grading Scale Adapted by Darmstadt From Lane et al — 1; 1; 1 score on a scale — p=0.99
N/A N=350 Trial of 2% Chlorhexidine Bathing on Nosocomial Infections in the Surgical Intensive Care Unit
Cross Infection · Pneumonia, Ventilator-associated · Catheter-related Infections
Primary: Incidence of Nosocomial Infection — 15; 30 participants — p=0.049
Phase 3 N=335 Test for Pre Operative Skin Preparations
Topical Antisepsis
Primary: log10 Reductions From Baseline for Each Test Parameter in CFU (Colony Forming Unit)/cm2 on Inguinal and Abdominal Sites — 3.51; 3.44; 3.15; 0.92 Average log10 reductions…
N/A N=932 Chlorhexidine-Alcohol Versus Povidone-Iodine for Cesarean Antisepsis
Surgical Site Infection
Primary: Number of Patients With Surgical Site Infection — 29; 33 Participants — p=0.38
N/A N=30 Effectiveness of Preoperative Surgical Scrubbing Using Clorhexidine Digluconate and Parachlorometaxylenol (ECP)
Skin Diseases · Surgical Site Infection
Primary: Change in the Release of Skin Flora From the Hands From Baseline to 5 Minutes After Disinfection by Surgical Scrubbing (Time Frame- "Baseline and 5 Minutes"). — 3.96…
N/A N=88 Surgical Site Infection With 0.05% Chlorhexidine (CHG) Compared to Triple Antibiotic Irrigation
Breast Cancer
Primary: Number of Participants With Surgical Site Infection — 7; 4 participants
Phase 4 N=112 Evaluation of Two Hand Hygiene Products in ICUs
Hand Hygiene Effectiveness
Primary: Bacterial Colony Forming Units Present on Hand Prints After Time Spent in Common Areas — 2.17; 1.81 log(10) transformed CFU
N/A N=1,356 STRIPES Study: Study To Reduce Infection Post cEsarean Section
Chlorhexidine Gluconate Cloths · Infection; Cesarean Section · Infectious Morbidity
Primary: Number of Participants With Incisional SSI — 17; 24 Participants
Phase 1 N=10 Pilot Study: Safety of Chlorhexidine (CHG) Baths in Patients Less Than 2 Months of Age
Chlorhexidine Allergy · Infection · Rash
Primary: Percentage of Study Participants With Skin Reactions Less Than 10% — 0; 2 Participants