Early Phase 1 N=300 Sedation Regimens in GI Endoscopy
Anesthesia · Endoscopy · Colonoscopy
Primary: Pain Felt During the Procedure — 0.29; 0.30 score on a scale
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=60 Conscious Sedation for Epilepsy Surgery
Epilepsy
Primary: Patients Satisfaction — 6.33; 6.45 score on a scale
Phase 4 N=50 Alternative Sedation During Bronchoscopy
Sedation
Primary: Decreased Minute Ventilation — 0.736; 0.764 percentage of baseline — p=<0.0001
N/A N=54 Ketamine Infusion and Hypoventilation
Hypoventilation
Primary: Intraoperative Hypoventilation — 1.2; 65 % time
N/A N=11 Sedation in Patients at Risk for Upper Airway Collapse
Obstructive Sleep Apnea
Primary: Respiratory Disturbance Index — 57.52; 21.32 events per hour
N/A N=102 Non-anesthesiologist-administered Propofol During the Flexible Bronchoscopy
Conscious Sedation Failure During Procedure
Primary: Change in Transcutaneous CO2 Pressure — 43.6; 45.6 Unit of Measure "mmHg" — p=0.281
N/A N=111 Nasal Continuous Positive Airway Pressure Versus Standard Care During Procedural Sedation for Gastrointestinal Endoscopy
Hypoxia · Endoscopy · Anesthesia Morbidity
Primary: Hypoxia Rate as Assessed by Number of Participants With at Least One Hypoxic Event — 3; 16 Participants
Phase 4 N=135 Propofol vs. Midazolam-based Balanced Propofol for Nonanesthesiologist Moderate Sedation in Colonoscopy
Procedural Sedation
Primary: Level of Sedation Throughout the Entire Procedure — 22; 9; 10; 1 participants
Phase 4 N=126 Propofol Versus Alfentanil Versus Nitrous Oxide for Moderate Procedural Sedation
Sedation
Primary: Number of Participants With Sub-clinical Respiratory Depression and Clinical Events Associated With Respiratory Depression During the Sedation Procedure — 11; 12…
Phase 4 N=107 Moderate Versus Deep Procedural Sedation With Propofol in the Emergency Department
Pain
Primary: Patients With Clinical Signs of Respiratory Depression or Sub Clinical Respiratory Depressions Measured by Capnography and Pulse Oximetry. — 22; 21 Participants
Phase 4 N=105 Sedation Methods During Cataract Surgery
Phacoemulsification · Cataract
Primary: Eye Mobility During Surgery (See Link to Study Protocol for Scale) — 1.39; 1.41; 1.31 units on a scale
Phase 4 N=20 Stress During Deep Sedation With Propofol With and Without Alfentanil
Sedation
Primary: Change in Serum Catecholamines — 87; 106 mcg/ml — p=0.940
N/A N=150 Patient-controlled Sedation With Propofol Versus Combined Sedation During Bronchoscopy
Sedation, Bronchoscopy
Primary: Discharge Assessment Using PADSS After 2 Hours Number of Patients Reaching PADSS Score 10 After 2 Hours — 19; 30; 45 Participants
Phase 4 N=271 Randomized Clinical Trial of Propofol, 1:1 and 4:1 Combination of Propofol and Ketamine for Procedural Sedation
Procedural Sedation
Primary: Clinical Interventions During Sedation — 41; 33; 48 Clinical interventions performed
N/A N=40 Probability Ramp Control of Propofol for EGD
Gastrointestinal Disease
Primary: Number of Participants Requiring Adjustment in Propofol Dosing — 16; 2 Participants
Phase 4 N=60 A Comparison of Intranasal Midazolam and Nitrous Oxide (N2O) Minimal Sedation for Minor Procedures in a Pediatric Emergency Department
Conscious Sedation · Simple Lacerations Less Than 4 cm · Lumbar Punctures
Primary: ED Length of Stay After Intranasal Midazolam or Nitrous Oxide Administration — 24.5; 18.5; 9; 10 minutes
N/A N=43 Adjunctive Nitrous Oxide During Emergency Department Propofol Sedation in Adults
Joint Dislocation · Perianal Abscess · Abscess
Primary: Total Number of Respiratory Depression Events — 0 events
Phase 4 N=114 Propofol and Dexmedetomidine Versus a Propofol Only Regimen for Sedation During Colonoscopy
Colonoscopy
Primary: Percentage of Subjects Ready for Discharge in Each Group at 30 Minutes Post Procedure — 26; 44 Participants
Phase 4 N=50 Dexmedetomidine vs Propofol TIVA (Total Intravenous Anesthesia) and Interscalene Block
Shoulder Pain
Primary: Number of Participants That Need an Airway Intervention. — 0; 5 participants
N/A N=82 Nitrous Oxide Use in Minor Procedures
Laceration · Abscess
Primary: FLACC Pain Scale — 8; 2 units on a scale
N/A N=41 Use of High Flow Nasal Cannula During Sedation of Morbidly Obese Patients in the Endoscopy Suite
Morbid Obesity · Noninvasive Ventilation · Deep Sedation
Primary: Ability to Maintain Oxygenation — 0.55; 0.61 manipulations
Phase 3 N=1,000 Safety and Effectiveness of a Computer-Assisted Personalized Sedation (CAPS) Device for Propofol Delivery During Endoscopy
Colonoscopy · Endoscopy, Digestive System · Conscious Sedation
Primary: Area Under the Curve for Oxygen Desaturation (AUCDesat) — 23.6; 88.0 seconds*percent of oxygen desaturation — p=0.028
N/A N=39 Nitrous Oxide Versus Intravenous Sedation for Anesthesia
Pregnancy Termination in Second Trimester
Primary: Visual Analog Scale (VAS) Score for Maximum Procedural Pain — 54.1; 34.0 units on a scale
N/A N=63 High-Flow Nasal Cannula and Desaturation Episodes in the Morbidly Obese Patients
Desaturation of Blood · Obesity · Colonoscopy
Primary: The Number of Desaturation Episodes — 0; 0 Episodes
Phase 3 N=50 Sedation Using Intranasal Dexmedetomidine in Upper Gastrointestinal Endoscopy
Gastrointestinal Disease
Primary: Consumption of Rescue Patient Controlled Propofol — 42.4; 28.6 mg
N/A N=10 Phamacological Reversal of Airway Instability During Sedation
Upper Airway Obstruction
Primary: AHI - Apnea Hypopnea Index — 14.5; 27.9; 11.3; 12.1 events per hour
Phase 4 N=173 Regimen of Alfentanil in Propofol Sedative Fibro-bronchoscopy
Hypoxemia
Primary: Effect Site Concentration When Conscious Level Reaches OAAS-3 — 2.3; 2.2; 2.5; 2.2 ug/ml
N/A N=289 Compare Propofol to Fentanyl and Midazolam for Colonoscopy
Colon Cancer · Rectal Cancer · Colonic Diverticulosis
Primary: Patient Satisfaction Scores (Absolute Value) — 98.0; 83.9; 98.1; 79.2 score on a scale
N/A N=150 Facilitating EndotracheaL Intubation by Laryngoscopy Technique and Apneic Oxygenation Within the Intensive Care Unit: The FELLOW Study
Respiratory Failure
Primary: Successful First Attempt at Endotracheal Intubation (Defined by Confirmed Placement of an Endotracheal Tube in the Trachea During First Laryngoscopy Attempt) After…
N/A N=20 Inhaled Nitrous Oxide for the Prevention of Emergence Reaction During Ketamine Administration in Adults, a Pilot Study
Emergence Reaction · Procedural Sedation
Primary: Emergence Reaction