30 closest matches · ranked by relevance
Contact Lens-induced Corneal Fluorescein Staining
Primary: The Primary Outcome Measure Will be Corneal Epithelial Dye Diffusion Rate in Nanometers Per Second, for the Test and Control Eyes. — 0.0567; 0.0583 nanometers per second
Myopia · Hyperopia
Primary: Corneal Sensitivity — 26.9; 25.5 percent CO2
Keratitis
Primary: Number of Participants Wiith Corneal Staining — 1; 6 participants
Conjunctival Staining
Primary: Mean Circumlimbal Conjunctival Staining Score — 6.39; 5.55; 5.68 Units on a scale
Refractive Error · Dry Eye
Primary: Mean Number of Viable Epithelial Cells Collected Directly From the Ocular Surface After 2 Hours and 4 Hours of Wear, Phase 1 — 15; 20; 18; 22 cells
Refractive Errors · Ametropia
Primary: Average Percent Area of Solution-related Corneal Staining — 7.01; 12.82; 13.54; 7.58 percentage of area
Conjunctival Staining
Primary: Conjunctival Staining at 1 Minute — 3.29; 3.67; 3.98 Units on a scale
Keratoconus
Primary: Number of Participants With an Observable Difference Between Virtual Versus Actual Fluorescein Patterns — 0 participants
Corneal Swelling
Primary: Percentage Change From Baseline of Corneal Swelling 8 Hours Post Fit — 0.07; -0.02; 0.14; -0.06 percentage of change from baseline
Corneal Staining
Primary: Corneal Staining by Wear Time — 19; 15; 19; 7 participants
Myopia · Hyperopia · Astigmatism
Primary: Number of Eyes With No Change in Corneal Staining — 16; 17; 19; 14 eyes
Allergic Conjunctivitis
Primary: Patient-Assessed Ocular Itching — 2.2; 2.2; 0.5; 0.5 units on a scale
Refractive Error
Primary: Mean Change From Baseline (Day 0) in Average Corneal Staining Area at Day 30 — -5.04 Percentage of corneal staining
Persistent Corneal Epithelial Defect
Primary: Percentage of Patients Achieving Corneal Healing (<0.5 mm2 Lesion Size) of the Persistent Corneal Epithelial Defect at 4 Weeks — 5 Participants
Normal Contact Lens Wear
Primary: HRT Corneal Scan — 85; 66; 49; 63 cells/mm^3
Refractive Errors
Primary: Average Percent Area of Corneal Staining — 2.93; 0.45; 6.06; 3.52 percentage of area
Contact Lens Care
Primary: Solution-Related Corneal Staining — 0 Percentage of participants
Ametropia
Primary: Endothelial Bleb Areas on Cornea: Session A- Open Eye — 0.1; 2.0; 0.2; 2.1 Percent Difference of Bleb Area
Corneal Inflammation · Corneal Infiltrative Events
Primary: Corneal Infiltrate Events - Phase I — 18.6; 5.7 percentage of subjects
Keratoconus · Post-Refractive Ectasia
Primary: Change in Maximum Keratometry From Baseline to 6 Months After Treatment — 0.76; 0.97 diopters
Corneal Ulcer · Infectious Keratitis · Bacterial Ulcer
Primary: Microbiological Cure on Repeat Culture — 5; 5; 17; 14 Participants
Corneal Swelling
Primary: Central Corneal Swelling — 542.2; 542.4; 544.3 um
Progressive Keratoconus
Primary: Mean Change From Baseline in Maximum Keratometry (Kmax) — -1.7; 0.6 diopters
Myopia
Primary: Corneal Thickness — -0.35; -0.99; 0.75; -1.02 Percent Change — p=0.0035
Corneal Ulcer · Eye Infections, Bacterial
Primary: Best Spectacle-corrected Visual Acuity (BSCVA) in logMAR at 3 Months, Using Best Spectacle-corrected Enrollment Visual Acuity as a Co-variate — 0.48; 0.49 logMAR — p=0.82
Corneal Staining
Primary: Proportion of Participants Scoring ≥ 2 for Corneal Staining Density With Fluorescein — 92.6; 22.2 percentage of participants
Dry Eye Syndrome
Primary: Mean Change From Baseline in Total Ocular Surface Staining (TOSS) Score at Day 35 (Phase I) — -2.2; -1.7 units on a scale
Ectasia
Primary: Mean Change From Baseline in Maximum Keratometry (Kmax) — -0.5; 0.5 diopters
Myopia · Refractive Error
Primary: Corneal Epithelial Immune Dendritic Cell Density (Central Cornea) — 46.2; 44.8; 62.3 cells/mm2
Visual Acuity
Primary: Monocular Distance Visual Acuity (VA) — 258; 263 Eyes