N/A N=18 Corneal Topographer Fluorescein Patterns
Keratoconus
Primary: Number of Participants With an Observable Difference Between Virtual Versus Actual Fluorescein Patterns — 0 participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=50 Study of Clinical Performance of Corneal Topography Measurement Using an Optical Biometer
Corneal Topography
Primary: In-vivo Repeatability of Corneal Topography Measurements With Lenstar LS 900 Topography: Sample Mean of Differences of Mean Power and Sample Mean of Std. Dev of Local…
N/A N=45 Effect of TrueTear Corneal Surface Imaging
Cataract · Myopia
Primary: Surface Asymmetry Index (SAI) Assessed With Corneal Topography — 0.21 unitless
N/A N=59 Corneal Biomechanics and Corneal Reshaping Therapy
Myopia
Primary: Change of Corneal Stiffness From Baseline at 6 Months — 0.061 N/mm
N/A N=70 Clinical and Refractive Outcomes After Contoura® Refractive Surgery Planned Using Phorcides Surgery Planning Software
Refractive Errors
Primary: Residual Refractive Cylinder — 0.04 diopters
N/A N=51 Two Phase Clinical Study of the Impact of Contact Lenses and Solutions on Corneal Structure
Normal Contact Lens Wear
Primary: HRT Corneal Scan — 85; 66; 49; 63 cells/mm^3
N/A N=12 Custom Anterior Surfacing of Scleral Lens for Vision Quality Improvement in Patients With Keratoconus
Keratoconus
Primary: Number of Participants With Normal Vision — 8 Participants
Phase 3 N=212 Safety and Efficacy Study of Topography-Guided LASIK to Treat Myopia and Hyperopia
Myopia · Hyperopia
Primary: Percentage of Eyes With Manifest Refraction Spherical Equivalent (MRSE) +/- 0.50 D — 94.78 Percentage of Eyes
N/A N=50 Theranostic Guided Riboflavin/UV-A Corneal Cross-linking
Keratoconus
Primary: Validation of the Theranostic Scores — 91; 95 Percentage
N/A N=48 Topcon 3D OCT-1000 Optical Coherence Tomography System
Retinal Disease · Glaucoma
Primary: Precision and Agreement Between the Topcon 3D OCT 1000 and the Identified Predicate Device — 235.0; 236.1; NA; 236.0 µm
Phase 4 N=13 Confocal Analysis of Corneal Structures of Symptomatic Allergic Conjunctivitis Patients
Allergic Conjunctivitis
Primary: Patient-Assessed Ocular Itching — 2.2; 2.2; 0.5; 0.5 units on a scale
Phase 2 N=510 Corneal Crosslinking in Patients With Keratoconus and Post-Refractive Ectasia
Keratoconus · Post-Refractive Ectasia
Primary: Change in Maximum Keratometry From Baseline to 6 Months After Treatment — 0.76; 0.97 diopters
Phase 3 N=130 Corneal Collagen Cross-Linking for Ectasia (CXL)
Ectasia
Primary: Mean Change From Baseline in Maximum Keratometry (Kmax) — -0.5; 0.5 diopters
N/A N=204 Assessment of Measurement Variability Across Automated Biometry Devices
Myopia
Primary: The Correlation of White-to-white Measurements Between Biometric Devices. — 0.89; 0.65; 0.53; 0.60 Pearson correlation r
Phase 3 N=147 Corneal Collagen Cross-linking for Progressive Keratoconus
Progressive Keratoconus
Primary: Mean Change From Baseline in Maximum Keratometry (Kmax) — -1.7; 0.6 diopters
Phase 3 N=239 Study to Evaluate the Safety and Efficacy of Epi-on Corneal Cross-linking in Eyes With Progressive Keratoconus
Progressive Keratoconus
Primary: Difference Between Treatment Groups in the Change From Baseline to Month 6 in Kmax — -0.3; 0.6 Diopters — p=0.0004
N/A N=11 Pilot Study to Investigate the Feasibility, Reliability and Efficacy of Utilizing OCT to Automate PROSE Fitting
Keratoconus · Ocular Surface Disease · Pellucid Marginal Corneal Degeneration
Primary: Central Corneal Clearance — 354.29 microns
N/A N=94 Simultaneous TransPRK and Corneal Collagen Cross-Linking
Keratoconus
Primary: Change in LogMAR Corrected Distance Visual Acuity (CDVA) — -0.13; -0.05 LogMAR CDVA — p=0.03
N/A N=30 Transepithelial Corneal Cross-linking Using Iontophoresis
Progressive Keratoconus
Primary: K-max — -0.52; -0.82 Diopters (D) — p=<0.05
N/A N=40 Sutureless Cryopreserved Amniotic Membrane Graft (ProKera) and Wound Healing After Photorefractive Keratectomy
Corneal Wound Healing
Primary: Number of Days to Complete Re-epithelialization — 4.6; 4.1 days to complete re-epithelialization
N/A N=23 Toric Contact Lens Digital Performance and Comfort Study
Astigmatism
Primary: Near Visual LogMAR Acuity — -0.10; -0.03 LogMAR
Phase 3 N=50 Comparison of Cross-cylinder and Conventional Photorefractive Keratectomy(PRK) in Correcting Medium-high Astigmatism
Astigmatism
Primary: Correction of Astigmatism — -0.54; -0.59 diopter — p=<0.05
N/A N=84 Conventional Surgery vs. Verion/VerifEye
Cataract · Astigmatism
Primary: Residual Refractive Cylinder — 0.28; 0.33 Diopters
N/A N=135 Performance and Safety Assessment of T4020 in Managing Corneal Epithelial Defect Following Epi-off Accelerated Crosslinking
Keratoconus
Primary: Number of Participants With Complete Healing of Corneal Epithelial Defect at Day 3 — 20; 25 Participants
N/A N=40 Assessment of Visual Performance in Patients With Low Levels of Astigmatism
Cataract Extraction · Corneal Astigmatism
Primary: High and Low Contrast Acuity — 0.0855; 0.065; 0.082 logMAR
N/A N=40 Visual Performance Investigation of Two Toric Soft Contact Lenses
Refractive Error · Astigmatism · Myopia
Primary: Mean Ocular Coma Score at 5mm Pupil at Day 30 — 0.16; 0.24 micrometers
N/A N=35 Toric Contact Lens Performance Study
Astigmatism
Primary: Near Visual LogMAR Acuity — -0.09; -0.02 LogMAR
N/A N=21 Assessment of Contact Lens Wettability Using Wavefront Aberrometry
Visual Acuity
Primary: Higher Order Root Mean Square (HO RMS) - Near Target in Downgaze With Natural Blinking — 0.159; 0.142 microns
N/A N=303 Optical Coherence Tomography (OCT) Data Collection Study
Glaucoma
Primary: Primary Endpoints — 97.2; 83.9; 73.9; 336.1 microns
N/A N=59 WaveLight® Refractive Flap Accuracy Study
Refractive Error
Primary: The Difference Between Achieved Flap Thickness at Day 1 Postoperative as Assessed by OCT and Expected Flap Thickness as Determined Pre-operatively — 14.996; 13.644 microns