Clinical Trial Search

Primary: Leisure Activities Questionnaire Activities Sum — 1.45; 4.45; 11.25 score on a scale — p=<0.05

Primary: 12-Month Cumulative Incidence of ADRD Diagnoses — 213; 134; 355 Number of new ADRD cases — p=0.006

Primary: Quality of Life in Alzheimer's Disease (QOL-AD)--Participants With Dementia (PWD) — 35.42; 38.10; 35.56; 36.12 score on a scale

Primary: Percentage of Trials Correct On Working Memory Test — 87.69; 91.57; 88.01; 91.68 percentage of correct trials — p=>0.05

Primary: California Verbal Learning Test II — 6.9; 6.2; 6.46; 5.10 units on a scale — p=0.048

Primary: Amyloid Burden — 1.20; 1.22; 1.21; 1.22 Standard Uptake Value Ratio (SUVR)

Primary: Executive Function (EF). — 1.16; 0.99 z score

Primary: Depressive Symptoms — 9.736; 11.785; 8.880; 12.300 units on a scale — p=<.05

Primary: Stroop Test Performance From Pre- to Post-intervention — 137.67; 56.17; 116.51; 55.13 Time to complete (seconds)

Primary: Change in East Boston Memory Test Scores From Baseline to 24 Weeks, 48 Weeks, and 72 Weeks — 0.03; -0.02; 0.01; 0.05 score on a scale — p=.409

Primary: Physical Function — -4.7 score on a scale

Primary: Change in Quality of Life-Alzheimer's Disease Score — 12.32; 15.88 score on a scale

Primary: Rate of Change of Hippocampal Volume Slope — -70.2418748; -88.4738591; -94.0768115; -46.9484805 mm^3/year — p=0.095

Primary: Face-name Memory Test Performance — -.28; -.01; -1.29; -1.76 pairs correctly recalled/recognized

Primary: Time to Dispensing of Inappropriate Medication Prescription — 76.7; 77.9; 77.5 Percentage of Cumulative Incidence — p=0.76

Primary: Quality of Life Scale in Alzheimer's Disease (QOL-AD) — 38.8; 40.0 score on a scale — p=0.14

Primary: Number of Participants With Aggression as Determined by the Cohen-Mansfield Agitation Inventory (Aggression Subscale) — 8; 14; 9; 17 participants — p=0.13

Primary: Changes in Global Cognitive Function Using Mini Mental State Examination Score (Post-study Test Score - Baseline Test Score) — -0.51; -0.07 score on a scale — p=0.25

Primary: Change in Caregiver Burden at 6 and 12 Months — 29.99; 30.09; 28.1; 28.13 units on a scale — p=0.76

Primary: Change in Global Cognitive Function as Assessed by the Wechsler Memory Scale-III — -0.2; -0.2 score on a scale

Primary: Overall Score Changes From Baseline by Magnesium Treatment vs. Placebo — 1.1; 0.6 score on a scale — p=0.20

Primary: Dispensing of Psychotropic Medications — 161; 315 Participants — p=0.492

Primary: Rivermead Behavioral Memory Test — 11.08; 11.2; 12.31 units on a scale

Primary: Word List Memory Total - ADAS-cog — 14.35; 14.7; 15.1; 14.67 Words recalled

Primary: Percentage of Participants Completing the Study — 90 Percentage of participants

Primary: Number of Participants With a Decline of 6 Points on the Hopkins Verbal Learning Test-Revised (HVLT-R) — 1; 9 Participants — p=.02

Primary: Change in Global Cognition Score — -0.012; 0.021; 0.18; 0.32 Composite z-score

Primary: Change in Baseline Burden and Stress of Caregivers Over 3 Months — -52.0; -31.9 percentage change

Primary: Success Rate of Adherence — 2; 6; 7 Participants — p=0.12

Primary: Change in Number of Hospital Transfers Pre/Post Intervention — 0.97; 0.65; NA hospital transfers per 1000 person days