Phase 4 N=100 The Anesthetic Efficacy of 3% Mepivacaine Plus 2% Lidocaine With 1:100,000 Epinephrine for Lower Jaw Dental Injections
Pain
Primary: Number of Participants Achieving Pulpal Anesthesia Success. — 44; 40 Participants — p=1.00
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=60 Testing the Anesthetic Effectiveness of Three Different Dental Local Anesthetics Injected Next to a Lower First Molar
Anesthetic Effectiveness
Primary: Successful Pulpal Anesthesia. — 37; 27; 22; 33 participants
Phase 4 N=201 Efficacy Study of Articaine Versus Lidocaine as Supplemental Infiltration in Inflamed Molars
Irreversible Pulpitis
Primary: Anesthetic Success Rate of Supplemental Infiltration Injection — 22; 25; 23; 12 Participants — p=.901
Phase 2 N=45 Safety and Effectiveness of Kovacaine Nasal Spray for Dental Anesthesia
Dental Anesthesia Efficacy
Primary: Pulpal Anesthesia — 25; 14 participants
Phase 4 N=50 Lower Third Molar Removal With 2% and 4% Articaine
Impacted Third Molar Tooth · Adverse Reaction to Other Local Anesthetics
Primary: Onset of Anesthetic — 1.5; 1.5 minutes — p=0.192
Phase 4 N=35 Effect of Post-Operative Anesthetics on Post-Operative Pain in Patients Receiving Endodontic Treatment
Endodontic Disease · Post Operative Pain · Symptomatic Irreversible Pulpitis
Primary: Post-operative Pain Level 6 Hours on a Visual Analog Scale — 64.2; 43.1 units on a scale
Phase 3 N=59 The Effect of Local Anesthesia on Control of Intraoperative Physiologic Parameters and Post Operative Comfort
Pain, Procedural
Primary: Post Operative Pain — 13; 10 Participants
Phase 4 N=80 Testing the Anesthetic Effectiveness of Buffered Articaine Injected Next to a Lower First Molar.
Anesthetic Effectiveness
Primary: Number of Participants Achieving Pulpal Anesthesia. — 52; 57 Participants
N/A N=160 Success Rate of 4 Injection Protocols for Mandibular First Molars With Symptomatic Irreversible Pulpitis
Root Canal Infection
Primary: Number of Participants With Successful Injection Technique Assessed by Verbal Rating Scale (VRS) — 16; 37; 29; 26 Participants
N/A N=50 Effectiveness of the Comfort-In Needle Free Injection System During Palatal Infiltrative Anesthesia
Physiological Effects of Drugs · Anesthetics
Primary: Pain Perception Measured by the Wong-Baker FACES Pain Rating Scale — 1.04; 4.24 score on a scale
Phase 4 N=40 Buffered vs. Unbuffered Local Anesthesia in Mandibular Molars Diagnosed With Symptomatic Irreversible Pulpitis
Symptomatic Irreversible Pulpitis
Primary: VAS Scores as Measures of Profoundness of Pulpal Anesthesia — 3.1; 1.2 Score on a scale
N/A N=60 Evaluation of the Dental Vibe Injection Comfort System
Anesthesia, Local · Pain
Primary: VAS — 2.5; 2.3; 2.7; 4.2 score on a scale — p=0.001
N/A N=96 Comparing Two Anesthetic Techniques for Implant Placement
Edentulous Jaw · Dental Implant · Anesthesia, Local
Primary: Pain Perception by Numerical Rating Scale — 0; 0 score on a scale
Phase 2 N=30 Open-Label Study of Efficacy and Recommended Dose of Kovacaine Mist for Anesthetizing Maxillary Teeth
Anesthesia
Primary: The Proportion of Subjects Receiving Kovacaine Mist Who do Not Require Rescue Anesthesia During the Operative Dental Procedure — 10; 7; 8 participants
Early Phase 1 N=60 The Effect of Er,Cr:YSGG Laser-assisted Topical Anesthetic on Oral Mucosal Anesthesia
Anesthesia
Primary: Insertion Depth at Initial Sensory Detection — 7.75; 4.65; 0.4; 8.55 mm
Phase 4 N=26 Clinical Trial Comparing Effectiveness of Buffered Versus Unbuffered Local Anesthetic in Children Ages 10-12 Years
Anesthesia, Local · Pain
Primary: Mean Pain Scores Following Injection — 3.0; 3.3 score on a scale — p=0.38
Phase 4 N=20 Comparison of Pain of Conventional to Buffered Local Anesthesia During Injection in Pediatric Dental Patients
Pain
Primary: Participant Pain Experience After Administration of Local Anesthesia to Numb the Gums and Teeth During Dental Treatment — 43; 33.1; 7.3; 9.8 units on a scale — p=0.23
Phase 3 N=150 Comparison of Intranasal Kovacaine Mist, and Placebo for Anesthetizing Maxillary Teeth in Adults
Anesthesia
Primary: Number of Participants Who Completed the Study Dental Procedure Without Need for Rescue by Injection of Local Anesthetic. — 88; 14 participants
Phase 3 N=110 Comparison of Intranasal Kovacaine Mist, Tetracaine Alone, and Placebo for Anesthetizing Maxillary Teeth in Adults
Anesthesia
Primary: Number of Participants Who Completed the Study Dental Procedure After Without Need for Rescue by Injection of Local Anesthetic. — 84.1; 27.3; 27.3 percentage of patients
N/A N=49 Efficacy of Injected Local Anesthetic vs Topical Anesthetic in Cosmetic Injectable Fillers.
Anesthesia
Primary: Participants Anesthetic Preference — 32; 16 participant preference selection
N/A N=499 Efficacy of an Internet-based Intervention for Dental Anxiety
Dental Anxiety
Primary: Change in Modified Dental Anxiety Scale (MDAS; Humphris et al., 1995). — 19.8; 19.4; 19.4; 16.7 score on a scale
Phase 4 N=64 Comparison of Two Topical Anesthetics: Benzocaine Versus Pliaglis
Anesthesia of Mucous Membrane
Primary: Measurement of Pain Associated With Injection, in Millimeters, According to Visual Analog Scale — 38.5; 26.9 mm
Phase 3 N=90 Comparison of Intranasal Kovacaine Mist, and Placebo for Anesthetizing Maxillary Teeth in Pediatric Patients
Anesthesia
Primary: Number of Participants Who Completed the Study Dental Procedure Without Need for Rescue by Injection of Local Anesthetic. — 46; 16 Participants
N/A N=23 Effect of the DentalVibe Injection System on Pain During Local Anesthesia Injections in Children
Pain
Primary: Self Reported Pain Rating Using Wong-Baker FACES Scale — 3.57; 5.13 score on a scale
N/A N=91 Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Local Anesthetics
Methemoglobinemia
Primary: Peak Methemoglobin Blood Levels — 3.55; 1.63; 1.60 percentage of methemoglobin in blood — p=<.001
Phase 3 N=233 Lidocaine + Clonidine for Intraoral Anesthesia in Patients With Diabetes Mellitus Type 2
Diabetes Mellitus · Local Anesthesia
Primary: Duration of Intraoral Local Anesthesia — 132.48; 173.27; 182.09; 195.35 minutes — p=<0.05
Phase 3 N=374 A Dental Pain Study Comparing The Analgesic Efficacy Of Ibuprofen/Caffeine
Pain
Primary: Time Weighted Sum of Pain Relief Rating (PRR) and Pain Intensity Difference (PID) Scores From 0 to 8 Hours Post-dose (SPRID 0-8): Ibuprofen + Caffeine Versus Ibuprofen…
Phase 4 N=24 Clinical Outcomes Mandible: Buffered 1% vs. Non-Buffered 1% Lidocaine
Anesthesia, Local
Primary: Mean Time to Pulpal Response After Mandibular Molar Anesthesia — 100; 106 minutes
Phase 4 N=64 Buffered Lidocaine in the Pediatric Dental Patient
Pediatric Dentistry
Primary: Patient Reported Pain Perception — 3.52; 3.48 units on a scale
Early Phase 1 N=114 Pre-operative Analgesics for Postoperative Pain Relief After Dental Treatment
Pain, Postoperative · Analgesia
Primary: Postoperative Pain, as Measured by Wong-Baker Facial Rating Pain Scale ,After Routine Dental Treatment — 20; 20; 7; 11 Participants