N/A N=56 Dyspareunia and Central Sensitization
Endometriosis · Central Sensitisation · Dyspareunia
Primary: Deep Dyspareunia Score — 3.08 scores on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=50 Treating Postmenopausal Dyspareunia Where it Hurts
Dyspareunia
Primary: Change in Median Dyspareunia Pain Scores After 4 Weeks Using Study Drug — -1.5; -3 score on a scale — p=0.08
Phase 3 N=550 Study to Evaluate Safety and Efficacy of WC3011 (Estradiol Vaginal Cream) in Postmenopausal Women With Dyspareunia
Vulvovaginal Atrophy
Primary: Change From Baseline in Participant's Self-Assessment of Symptom of Vulvovaginal Atrophy (VVA): Dyspareunia (Pain Associated With Sexual Activity) to Final Assessment…
Phase 2 N=49 Vaginal Diazepam for the Treatment of Female Pelvic Pain
Pelvic Floor Disorders · Pelvic Pain
Primary: Visual Analog Scale (VAS) for Pain — 50; 39 score on a scale — p=0.62
Phase 2 N=209 Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments
Vestibulodynia · Temporomandibular Disorder · Fibromyalgia Syndrome
Primary: Pain Score During the Tampon Test — 4.37; 3.75; 4.04; 4.36 score on a scale — p=0.3630
Phase 3 N=9 Novel Topical Therapies for the Treatment of Genital Pain
Female Genital Diseases
Primary: Reduction in Daily Genital Pain. — 2.4; 2.92; 3.42; 2.77 units on a scale — p=0.30
N/A N=318 Rapidly Absorbing Polyglactin 910 Versus Poliglecaprone 25 for Laceration Repair
Dyspareunia · Perineal Tear · Sutured Laceration
Primary: Rates of Dyspareunia — 3.6; 3.49 units on a scale — p=0.16
Phase 2 N=9 CC-10004 For The Treatment Of Vulvodynia
Vulvodynia
Primary: Global Response Assessment — 5 participants
N/A N=69 Efficacy of Pain Neuroscience Education in Genito-Pelvic Pain/Penetration Disorder. A Randomized Controlled Trial.
Pain · Dysfunction Sexual
Primary: Visual Analogue Scale — 5.3; 5.8; 5.1; 3.8 score on a scale
N/A N=89 A Trial of Gabapentin in Vulvodynia: Biological Correlates of Response
Vulvodynia
Primary: Tampon Test Pain Intensity — 4.29; 3.96 units on a scale — p=0.07
Phase 4 N=353 Chronic Pain Risk Associated With Menstrual Period Pain
Cystitis, Interstitial · Dysmenorrhea · Migraine Disorders
Primary: Change in Participant Bladder Pain Sensitivity From Baseline. — 38.2; 37.0; 41.2; 47.9 score on a scale — p=.02
Phase 2 N=84 Efficacy and Safety Study of Lidocaine Vaginal Gel for Recurrent Dysmenorrhea (Painful Periods)
Dysmenorrhea
Primary: The Primary Efficacy Variable Will be the Time-weighted Average Pain Intensity Over 4 Treatment Days Using the 4 Point Categorical Scale. — 0.91; 0.92 units on a scale
N/A N=88 Pelvic Floor Shear-Wave Elastography in Healthy and Pudendal Neuralgia Women
Pudendal Nerve · Healthy Women
Primary: Superficial Pelvic Floor Muscle (Bulbospongiosus, Ischiocavernosus, Superficial Transverse Perineal Muscles)Stiffness (kPa) Measured by Shear-wave Elastography — 612…
N/A N=32 Injection of Botox in the Perineal Muscles in Resistant Cases of Vaginal Spasm
Vaginismus
Primary: Success of Repeated Penetration of the Penis Through the Vaginal Introitus Into the Vagina Without or With Acceptable Pain — 28 participants
Phase 3 N=919 Efficacy and Safety of Ospemifene in the Treatment of Moderate to Severe Vaginal Dryness and Vaginal Pain Associated With Sexual Activity
Atrophy · Vaginal Diseases
Primary: Change From Baseline to Week 12 in Percentage of Parabasal Cells in the Maturation Index of the Vaginal Smear (Dryness Strata) — -3.7; -31.7 percentage of parabasal cells
N/A N=16 Surface Stimulation for Female Sexual Dysfunction
Female Sexual Dysfunction
Primary: 6 Weeks - Total FSFI Score — 26.0; 17.4 score on a scale — p=0.109
N/A N=89 Effect of Acupuncture on Patient Vulvodynia Outcomes
Vulvodynia · Vulvodynia, Generalized · Vulvar Vestibulitis
Primary: Average Pain Intensity Will be Measured With the Pain Intensity Numbers Scale (PINS). — 3.90; 3.51; 2.48; 2.22 score on a scale — p=0.702
N/A N=67 Pain Control for Intrauterine Device Placement Using Paracervical Block
Pain Due to Intrauterine Contraceptive Device
Primary: Pain With Intrauterine Device (IUD) Placement — 54; 33 mm
Phase 4 N=10 Vulvoscopy Changes of the Vulva, Vestibule and Vagina With Daily Ospemifene in Women With Dyspareunia From VVA
Vulvovaginal Atrophy · Dyspareunia
Primary: Visible Changes to the Vulva, Vestibule and Vaginal Region on Photography — 8 points improvement on VGTA scale — p=0.05
Phase 2 N=439 A Study to Evaluate the Effect of Contraceptive Vaginal Rings on Primary Dysmenorrhea (P08257/MK-8175A/MK-8342B-057)
Dysmenorrhea
Primary: Change From Baseline in Mean Menstrual Cramping Pain Score Through Cycle 2 — -1.7; -1.7; -1.9; -1.7 Units on a scale — p=< 0.001
Phase 2 N=25 Viagra in the Treatment of Primary Dysmenorrhea
Dysmenorrhea
Primary: The Primary Outcome Was Total Pain Relief Over 4 Hours (TOPAR4), Comparing a Single Dose of Sildenafil 100 mg to a Single Dose of Placebo. — 11.9; 6.4 units on a scale…
Phase 4 N=1 Ulipristal for Endometriosis-related Pelvic Pain
Endometriosis
Primary: Pelvic Pain — 3.5; 0.2; 3.9 units on a scale — p=<0.05
Phase 3 N=50 Therapy to Prevent Sexual Pain in Breast Cancer Survivors
Vulvodynia · Dyspareunia · Breast Cancer
Primary: Prevention of Entry Dyspareunia With Non-hormonal Therapy — 5.3; 1.04; NA; 0.57 Units on a scale — p=0.0149
Phase 2 N=30 Botulinum Toxin for Pelvic Pain in Women With Endometriosis
Endometriosis · Chronic Pelvic Pain · Pelvic Muscle Spasm
Primary: Number of Participants With Improvement in Pain — 11; 4 Participants
N/A N=59 Self-administered Intravaginal 2% Lidocaine Gel Prior to Intrauterine Device Insertion in Nulliparous Women
Pain
Primary: Change in Pain From Baseline to IUD Insertion — 61; 68 change in visual analog scale score
N/A N=79 Trial of Tibial Nerve Stimulation for Treating Sexual Dysfunction
Female Sexual Dysfunction
Primary: Female Sexual Function Index (FSFI) — 16.72; 16.88; 22.02; 21.22 score on a scale
Phase 4 N=50 Paracervical Block Versus No Paracervical Block During IUD Insertion
Analgesia · IUD Insertion
Primary: Pain Score as Assessed by a Visual Analogue Scale (VAS) — 2.4; 2.1 units on a scale — p=0.59
Phase 4 N=20 Effect of Nicotine on Chronic Pelvic Pain
Pelvic Pain
Primary: Pain Score — 7.1; 6.4; 6.9 Units on a scale
Phase 2 N=16 Dysport in Post-Surgical Neuralgia
Chronic Scar Pain
Primary: Time to Onset of Effect in the Spontaneous Numerical Rating Scale (NRS) Score — 4.41; 15.11; 29.45; 0.65 days
Phase 4 N=26 Examining the Role of Improved NSAID Management in Treating Dysmenorrhea and Bladder Pain
Dysmenorrhea · Pain
Primary: Change in Menstrual Pain — 4.1 score on a scale — p=<0.0001