N/A N=88 Prolonged Daily Fasting as a Viable Alternative to Caloric Restriction in At-Risk Obese Humans
Obesity
Primary: Change in Weight — -3; -3.5; -1.3 Kg
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=105 Effects of Fast Bar on Physiological Fasting
Fasting
Primary: Ketone Area Under the Curve — 1.27; 0.62; 1.17 mg/dL*h
N/A N=20 Essential Amino Acids and Protein Kinetics During Caloric Deprivation
Muscle Protein Synthesis · Whole-body Protein Balance
Primary: Postprandial, Resting Muscle Protein Synthesis Rates — 0.055; 0.061 percent per hour
N/A N=30 Expression of Longevity Genes in Response to Extended Fasting
Cardiovascular Disease
Primary: Change From Baseline in Participant Glucose When Fasting and Fed — 83.3; -8.0; 5.9 mg/dL
N/A N=12 The Fasting II Study
Diabetes · Metabolic Diseases
Primary: Difference in Mean Glucose Level Between Baseline and the End of the Sixth Week. — 104.7; 104.5 mg/dL
Phase 4 N=50 Physiological and Psychological Effects of Testosterone During Severe Energy Deficit and Recovery
Caloric Restriction · Exercise
Primary: Body Composition at the End of Each Study Phase — 78.3; 78.0; 73.3; 75.8 kilograms
N/A N=100 Alternate Day Fasting for Weight Loss, Weight Maintenance and Cardio-protection
Coronary Heart Disease · Obesity · Weight Loss
Primary: Body Weight — -4.6; -4.5; 0.3 Percent change at month 12
N/A N=55 Intermittent Fasting and Metabolic Dysfunction Associated Fatty Liver Disease
Intermittent Fasting · Metabolic Dysfunction-Associated Fatty Liver Disease
Primary: Transient Elastography-Controlled Attenuation Parameter — 319.5; 343.5; 291.5; 285.0 db/m
N/A N=60 The Impact of Intermittent Fasting on Human Metabolism and Cell Autophagy
Excessive Diet Restriction
Primary: Insulin Sensitivity (HOMA-IR) — 0.05; 0.06 no unit
N/A N=80 Alternate Day Fasting, Exercise, and NAFLD
Non-Alcoholic Fatty Liver Disease · Obesity
Primary: Change in Hepatic Steatosis — -2.25; -1.3; -5.48; -0.17 liver fat percentage
N/A N=33 Time Restricted Eating for Metabolic and Psychological Optimization
Mild Cognitive Impairment · Obesity
Primary: Change in Memory Composite Rank — 6.22 rank — p=<0.001
N/A N=60 Effect of Intermittent Calorie Restriction on MASLD Patients With Abnormal Glucose Metabolism
Fatty Liver Disease · Type 2 Diabetes · Impaired Glucose Regulation
Primary: Change of Liver Fat Content in % — -20.5; -15.5; -7.6; -7.3 absolute fat content change in %
N/A N=77 Intermittent Fasting and a No-Sugar Diet for Long COVID Symptoms
Long Covid19 · Long COVID
Primary: Change in LC-Score, Per Treatment — -10.2; -2.8 Scores on a Scale
N/A N=21 Effects of Low Fat Versus Low Carbohydrate Diets on Energy Metabolism
Healthy · Healthy Volunteers
Primary: Ad Libitum Energy Intake — 2752; 2063 kcal per day
N/A N=37 Forearm Immobilization, Metabolic Health, and Muscle Loss
Healthy
Primary: Percent Change in Forearm Glucose Uptake — -73; 127; -95 Percent change in clamp FGU with immob
N/A N=6 Effects of Estrogen Deficiency on Energy Expenditure
Obesity
Primary: Brown Adipose Tissue Activity — 3.9; 4.0 Standard uptake value (SUV) — p=0.84
N/A N=54 Food Intake Response to Short-Term Modifications of Metabolism in Humans
Healthy Volunteers
Primary: 24-hour Energy Expenditure (kcal) — 2256; 2166; 2563; 2487 kcal
Phase 2 N=13 Role of Leptin in the Neuroendocrine and Immune Response to Fasting
Fasting
Primary: Cortisol — 17.5; 16.9 ug/dl
N/A N=50 Calorie-restricted, Ketogenic Diet and Transient Fasting During Reirradiation for Patients With Recurrent Glioblastoma
Recurrent Glioblastoma
Primary: Progression-free-survival — 20; 16 percentage of participants
N/A N=15 Effect of Caloric Restriction and Protein Intake on Metabolism and Anabolic Sensitivity
Weight Loss · Starvation
Primary: Change in Resting Metabolic Rate — -63.4; -77.6; -47.4 kcal change
N/A N=81 Pilot Study of Time Restricted Feeding as a Weight Loss Intervention
Obesity
Primary: Changes in Body Weight — -5.1; -6.2 kg
N/A N=206 Prevalence of Thiamine Deficiency in Hospitalized Non-Alcoholic Veterans
Thiamine Deficiency · Thiamine Deficiency; Sequelae
Primary: Percentage of Participants With Thiamine Deficiency (Low Plasma Thiamine) Out of Total Number of Enrolled Veterans With Plasma Thiamine Results — 49 Participants
N/A N=56 Effect of Energy Density Over 5 Days in Preschool Children
Feeding Behavior
Primary: Differences in Food and Beverage Intake by Energy — 956; 884; 1041 kilocalories — p=< 0.0001
N/A N=39 Effect of Caloric Restriction on Fat Oxidation in Obese Men and Women (Magellan II)
Obesity · Overweight · Metabolic Diseases
Primary: Change From Baseline Amount of Fat Oxidation at 14 Days — 0.91; 0.94 Fold change of RQ ratio
N/A N=47 Females, Aging, Metabolism, and Exercise
Obesity
Primary: Change in Physical Activity Energy Expenditure (PAEE) — 74.5; -10.2; 61.0 kcal/day
N/A N=32 Impaired Regulation of Energy Balance in Elderly People (Balance Study)
Anorexia of Ageing
Primary: Energy Intake Compensation — 1; 1 MJ/day
Phase 3 N=32 Behavioral Mechanism of Energy Compensation With Exercise
Obesity · Weight Loss · Eating Behavior
Primary: Attentional Bias — 48.85 percentage of time fixated on food cues
N/A N=98 Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation
Mild Cognitive Impairment · Metabolic Syndrome
Primary: MoCA (Montreal Cognitive Assessment) — 28.38; 20.22 score on a scale — p=<0.0001
N/A N=39 The Effect of Protein-enriched Diet on Body Composition and Appetite
Overweight · Obese · Metabolic Syndrome
Primary: Change in Lipid Content of the Liver (Intrahepatocellular Lipid) — 27.9; 9.3; 21.4; 5.9 % IHCL — p=<0.05
N/A N=26 Fatty Acid Oxidation Disorders & Body Weight Regulation Grant
Trifunctional Protein Deficiency
Primary: An Outcome of This Study is the Difference in Percent Body Fat (%BF) Between Subjects With a Long-chain Fatty Acid Oxidation Disorder and Normal Controls. — 31.8; 27.2…