Phase 3 N=13 Cardiovascular Effects of Racemic Epinephrine Pellets
Epinephrine Causing Adverse Effects in Therapeutic Use
Primary: Cardiovascular Outcomes — 91.5; 93.4 Beats Per Minute
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=49 Intramuscular Epinephrine as an Adjunctive Treatment for Severe Pediatric Asthma Exacerbation
Asthma
Primary: Change in Percent of Predicted Peak Expiratory Flow Rate (PEFR) at t15 — 59.56; 52.45 percentage of predicted
Phase 4 N=12 Pharmacokinetics of Intramuscular Adrenaline in Food--Allergic Teenagers
Anaphylaxis
Primary: Plasma Catecholamine Levels (Maximum Concentration, Cmax) — 218; 394; 290 pg/ml
Phase 4 N=20 Effect of Epinephrine on Post-polypectomy Pain
Colonic Polyp
Primary: Immediate Post-polypectomy Pain — 46.5; 13.6 units on a scale
N/A N=1,425 The Effect of Antihypertensive Drugs on Severity of Anaphylaxis and Side-effects During Venom Immunotherapy
Hymenoptera Venom Allergy · Antihypertensive Treatment
Primary: Frequency of Side Effects (=Systemic Reaction, SR) During Venom Immunotherapy (VIT) — 19; 74 Participants — p=0.25
Phase 2 N=23 Epinephrine Inhalation Aerosol USP, a HFA-MDI Study for Assessment of Pharmacokinetics
Asthma · Bronchospasm · Wheezing
Primary: Baseline Concentration (C0) of Total Epinephrine — 2.6; 4.3 pg/mL
Early Phase 1 N=9 Adrenergic System in Islet Transplantation
Type1diabetes · Hypoglycemia · Hypoglycemia Unawareness
Primary: C-PEPTIDE Suppression During Hyperinsulinemia Euglycemia. — 0.51; 0.56; 0.59 ng/mL
Phase 4 N=3,626 Norepinephrine vs Phenylephrine During General Anesthesia
Anesthesia · Surgery · Hypotension
Primary: Number of Participants With Assigned Vasopressor Given — 1570; 1627 Participants
N/A N=20 Acute Airway Vascular Smooth Muscle Effects of Inhaled Budesonide
Asthma
Primary: Airway Blood Flow (Qaw) — 22.3; 29.4; 34.1; 28.2 percentage of change from baseline
N/A N=22 Dexmedetomidine and Adenosine: Therapeutic Use for SVT
Supraventricular Tachycardia
Primary: Termination of SVT — 16; 21 participants
Phase 4 N=89 Effect of Nebulized Bronchodilators on Heart Rate
COPD · Sepsis · Shock
Primary: Heart Rate in Beats Per Minute — -0.16; 1.40 bpm — p=0.01
N/A N=96 Effect of Epinephrine/ Phenylephrine for Preventing the Postreperfusion Syndrome During Reperfusion in Liver Transplantation
Hypotension After Reperfusion in Liver Transplantation
Primary: Occurrence of Postreperfusion Syndrome (PRS) — 45; 39; 87 percentage of participants
Phase 2 N=66 The Prevention of Hypotension After Epidural Analgesia After Major Surgery
Hypotension · Pain
Primary: Changes Between the 3 Groups Assessed by Blood Pressure Measurement — 5; 2; 3; 10 Participants — p=0.165
Phase 4 N=28 Study of Drug Exposure in Systemic Circulation of Primatene Mist by Oral Inhalation, Versus Epinephrine Injection by Intramuscular Injection and ProAir by Oral Inhalation in Healthy Individuals
Pharmacokinetics · Epinephrine · Albuterol
Primary: C[Max], Maximum Plasma Concentration of Albuterol or Epinephrine — 240.8; 704.8; 599.8 pg/mL
Phase 4 N=30 Cardiovascular Effects of Adderall in Healthy Adults.
Hemodynamics · Cardiovascular System
Primary: Systolic Blood Pressure — 116; 116; 126; 115 mmHg
N/A N=110 Phenylephrine in Spinal Anesthesia in Preeclamptic Patients
Preeclampsia · Hypotension
Primary: The Umbilical Artery pH — 7.22; 7.20 pH — p=.38
N/A N=14 Effect of Formoterol on the Counterregulatory Hormonal Response to Hypoglycemia in Type 1 Diabetes.
Type 1 Diabetes
Primary: Glucagon (pg/mL) — 76; 74; 53; 56 pg/mL
Phase 4 N=798 Ancillary Effects of Dexmedetomidine Sedation After Cardiac Surgery
Heart Disease
Primary: Number of Patients With Atrial Arrhythmia — 121; 134 Participants — p=0.34
N/A N=30 The Various Effects of Gaseous Albuterol on Serum Lactate
Asthma
Primary: Number of Subjects With a Change From Baseline Serum Lactate Following a One Hour Albuterol Nebulizer Treatment. — -0.15; 0.77 mmol/L
N/A N=22 Acute Effect of Mometasone on Beta-adrenergic Airway and Airway Vascular Relaxation in Severe Asthma
Asthma
Primary: Albuterol-induced Change in FEV1 — 0.27; 0.18; 0.32; 0.20 liters
Phase 3 N=727 Comparing Vasopressin and Adrenaline in Patients With Cardiac Arrest
Cardiac Arrest
Primary: Survival to Hospital Discharge. — 8; 11 Participants
Phase 2 N=100 Physiologic Effects of Steroids in Cardiac Arrest
Inhospital Cardiac Arrest
Primary: Early Postresuscitation Arterial Blood Pressure (mmHg) Measured Through Institution of Invasive Intra-arterial Pressure Monitoring (as Feasible). — 78.4; 75.1 mmHg…
Phase 2 N=24 Pharmacokinetics (PK) Study of Epinephrine Inhalation Aerosol in Healthy Volunteers
Asthma
Primary: Baseline Concentration (C0) of Labeled Epinephrine Total Epinephrine — 9.3; 8.9; 7.8 pg/mL
Phase 3 N=15 The Effects Of Bronchodilator Therapy On Respiratory And Autonomic Function In Patients With Familial Dysautonomia
Familial Dysautonomia
Primary: Change From Baseline of Forced Vital Capacity — 5.5; 4.7; 0.9 percentage change from baseline
N/A N=24 Change in Oxygen Consumption Following Inhalation Beta Agonists in Healthy Adults
Oxygen Consumption
Primary: Oxygen Consumption — .28; .27 mls/kg/min
Phase 3 N=66 Prophylactic Topical Epinephrine to Reduce Bleeding in Transbronchial Lung Biopsies
Lung Transplant; Complications, Mechanical · Lung Transplant; Complications · Bleeding
Primary: Intra-procedural Hemorrhage Grading by the Performing Bronchoscopist — 4; 13; 11; 24 Procedures
Phase 2 N=21 The Effect of HFA - Beclomethasone Dipropionate Qvar on Bronchial Hyperreactivity in Preschool Children
Asthma · Bronchial Hyperresponsiveness
Primary: Adenosine Challenge Test — 18.46; 142.61 mg/ml
Phase 3 N=945 The Use of Inhaled Corticosteroids in the Treatment of Asthma is Children in the Emergency Room
Status Asthmaticus
Primary: Patients Hospitalization Rate — 82; 75 participants
Phase 4 N=32 Effects of Salmeterol on Autonomic Nervous System
Pulmonary Disease, Chronic Obstructive
Primary: Change in Muscle Sympathetic Nerve Activity (MSNA) at 2 Hours (Week 0) — -1.3 Bursts/100 heart beats — p=0.5062
N/A N=14 Interactive Acute Smooth Muscle Effects of Salmeterol and Fluticasone in the Airway
Asthma
Primary: Maximum Change From Baseline in Airway Blood Flow (Qaw) — -11.0; 14.1; 23.9; 25.5 change from baseline ( µl/min/ml) — p=< 0.001