Phase 2 N=308 Harm Reduction With Pharmacotherapy (HaRP)
Alcohol Use Disorder
Primary: Alcohol Quantity — 27.37; 25.95; 32.02; 32.15 number of drinks on peak occasion — p=.461
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=25 Harm Reduction Strategies for Gay, Bisexual and Other Men Who Have Sex With Men Engaging in Chemsex
Harm Reduction
Primary: Usability of the App — 2.14 Scores on the MAUQ
N/A N=57 THRIVE: Culturally AdapTed Harm Reduction Intervention
Opioid Use · Stimulant Use
Primary: Participant Confidence Using Harm Reduction Techniques at Baseline — 5.43; 6.61 score on a scale
N/A N=306 Ending Transmission of HIV, HCV, and STDs and Overdose in Rural Communities of People Who Inject Drugs (ETHIC)
HIV · Hepatitis C · Opioid-use Disorder
Primary: Total Participants Who Received Referrals to the Harm Reduction Services Organization — 121 Participants
N/A N=327 Community-Based, Client-Centered Prevention Homes to Address the Rural Opioid Epidemic- Aim 3
Drug Use Disorders · Hepatitis C · Harm Reduction
Primary: Change in the Addiction Treatment Accessibility and Utilization as Assessed by Change in Likert Scale — 1.26; 1.07; 1.12; 1.03 score on a scale — p=0.84
N/A N=304 Testing a Community-Friendly Risk Reduction Intervention for Injection Drug Users
HIV · Opioid Dependence
Primary: Demonstrated Drug Risk Reduction Skills (0-100%) — 40.60; 42.75 Percentage of correct steps
N/A N=127 Cocaine Use Reduction and Health
Cocaine Use Disorder
Primary: Endothelin-1 Levels — 2.15; 2.063; 1.956 pg/ml
N/A N=106 Secondary HIV Prevention and Adherence Among HIV-infected Drug Users
Risk Behavior · Medication Adherence · HIV
Primary: Number of Participants in Each Condition With Optimal ART Adherence — 27; 29 participants
N/A N=240 HealthCall:Brief Intervention to Reduce Non-injecting Drug Use in HIV Primary Care Clinics
Mental and Behavioral Disorders Due to Harmful Drug Use
Primary: Total Number of Days of Primary Drug Used in the Prior 30 Days — 5.07; 3.61; 4.73 Days
N/A N=529 The Impact on Linkage-to-care of an Alternative Hepatitis C Screening Method in PWID
Hepatitis C · Drug Users · Harm Reduction
Primary: Percentage of HCV Infected Paticipants Whom Result of the Test Was Delivered to — 101 Participants
N/A N=35 Adaptation of SFA for HRW
Occupational Health
Primary: Mean Knowledge of Stress First Aid (SFA) Assessed by Stress First Aid Knowledge, Confidence, and Beliefs - Knowledge Sub-Scale at 4 Months — 4.01 Score on a Scale
N/A N=100 Electronic Cigarettes (E-cigarettes) as a Harm Reduction Strategy
Tobacco Use Disorder · Smoking
Primary: Changes in the Number of Cigarettes Per Day (CPD) — 8.2; 7.3 cigarettes per day (CPD)
N/A N=87 Effectiveness of Opiate Replacement Therapy Administered Prior to Release From a Correctional Facility - 1
HIV Prevention · Opioid-Related Disorders
Primary: Treatment Engagement — 23; 11; 6 participants — p=<0.001
Phase 4 N=44 Relapse Prevention to Reduce HIV Among Women Prisoners
Opioid Dependence · HIV
Primary: Opiate Positive Urines With Missing Urines Coded as Positive at Week 12. — 14; 5 participants
N/A N=240 Prevention of OUD: The HOME Project (Housing, Opportunities, Motivation and Engagement)
Substance Use
Primary: Frequency (% Days) of Opioid Use in Prior 3 Months — 0; 0 % days opioid use
N/A N=400 Brief Intervention for Rural Women at High Risk for HIV/HCV
Acquired Immune Deficiency Syndrome Virus · Hepatitis C · Drug Abuse
Primary: Number of Participants Having Unprotected Casual Sex — 27; 25 Participants
Phase 4 N=319 Increasing Naloxone Access for Persons Who Use Opioids
Naloxone
Primary: The Number of Participants That Completed the Training in 6 Months — 55; 56; 10; 9 Participants
N/A N=198 Hepatitis C Treatment to Prevent HIV, Initiate Opioid Substitution Therapy, and Reduce Risky Behavior
HCV · Buprenorphine · PreP
Primary: Hepatitis C Virus (HCV) Cure (Sustained Virologic Response) — 158 Participants
Phase 2 N=584 Behavioral Intervention to Reduce Sexual and Injection Risks Among Female Sex Workers Who Also Inject Drugs in Mexico
HIV · HIV Infections
Primary: Combined HIV/STI 12-month Incidence Rates of HIV, Syphilis, Chlamydia, Gonorrhea and Trichomonas Vaginalis. — 65.02; 67.66; 35.02; 54.04 incidence density per 100 person…
N/A N=533 A Digital Intervention to Prevent the Initiation of Opioid Misuse in Adolescents in School-based Health Centers
Opioid Misuse
Primary: Percentage Reporting 'Great Perceived Risk of Harm' From Opioid Misuse — 66; 53 Participants
N/A N=40 Hepatitis C Pharmacy-based Strategy for Injectors
Hepatitis C
Primary: Community Pharmacy Program Successful Linkage — 38 Participants
N/A N=51 Planning a Multi-Level Intervention to Reduce Substance Use Stigma in HIV Prevention and Care
Social Stigma · Substance Use Disorders · HIV Infections
Primary: Provider-based Stigma (Social Distance Scale (SDS) Measure) — 9.09; 11.89 score on a scale — p=<0.001
N/A N=47 HealthCall-S: A Pilot Study Targeting Concurrent Non-injection Drug Use and Alcohol in HIV Primary Care Clinics
Alcohol or Other Drugs Use
Primary: Mean Number of Days Used Primary Drug (NumDU) — 8.5; 5.0 days
N/A N=665 Screen, Treat and Retain Meth-using People With Opioid Use Disorders at Methadone Clinics
Methamphetamine Abuse · Opioid-use Disorder · HIV Seropositivity
Primary: Increase in HIV Viral Suppression for HIV-positive Participants: High- vs. Low-Intensity Frontline Intervention With SMS in Stage 2 — 31; 35; 6; 3 Participants — p=0.447
N/A N=38 HIV and Alcohol Research Center Focused on Polypharmacy (HARP) Pilot 1
HIV · Alcohol Use
Primary: Enrollment to Assess Feasibility — 50 Participants
N/A N=237 Testing an Integrated Bio-Behavioral Primary HIV Prevention Intervention Among High-Risk People Who Use Drugs
Risk Behavior · HIV/AIDS · Medication Adherence
Primary: Pre-exposure Prophylaxis (PrEP) Adherence Behavior — 25.9; 22.8 score
N/A N=720 Building on Needle Exchange to Optimize Prevention & Treatment
Intravenous Drug Usage · HIV/AIDS
Primary: Composite PWID Score (Service Access, Risk Behaviors, Adverse Outcomes) — 5.34; 5.64 units on a scale — p=0.125
N/A N=86 Feasibility of SBIRT-PN
Substance Use · HIV/AIDS · Older Adults
Primary: Number of Participants Ranking Intervention as Acceptable — 9; 5 Participants
N/A N=511 Sustainable HIV Risk Reduction Strategies for Probationers
Health Behavior
Primary: HIV Knowledge Confidence — 42.9; 40.5 units on a scale — p=<.001
N/A N=97 Specialized Community Disease Management to Reduce Substance Use and Hospital Readmissions
Drug Use · Alcohol Use · Congestive Heart Failure
Primary: Change in Substance Use Rates From Baseline — 51.37; 51.38; 35.53; 26.65 Days of Substance Use