Phase 2 N=26 Hyperalgesia in Methadone-Maintained Patients: Can it be Treated?
Opioid-Induced Hyperalgesia
Primary: Change in Pain Threshold Time From Baseline to Week 5 — 2.95; -3.49 seconds
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=22 Study on the Development of Opioid Induced Hyperalgesia (OIH) After Exposure to Alfentanil
Hyperalgesia
Primary: Pain Tolerance — 105.3; 19.2 seconds
N/A N=28 Research Study to Determine Sensitivity to Gentle Touch and Pressure During an Active Migraine Attack.
Migraine
Primary: Proportion of Subjects With Allodynia During a Migraine Attack — 15 participants
Phase 3 N=626 The Efficacy of a Toothpaste to Reduce Sensitivity
Dentin Hypersensitivity
Primary: Hypersensitivity Tactile(Yeaple Probe) — 19.81; 13.94 units on a scale — p=0.05
N/A N=38 Prevalence of Phonophobia and Cutaneous Allodynia in Episodic Migraineurs
Migraine
Primary: Correlation Between Phonophobia (Sound Sensitivity) and Allodynia (Skin Sensitivity) in Subjects With Episodic Migraine — 27; 6 participants — p=0.59
N/A N=100 Mechanisms of Sleep Disruption Hyperalgesia
Sleep Deprivation · Pain
Primary: Spinal Sensitization as Assessed by Area of Secondary Hyperalgesia (2HA) After Two Nights of Uninterrupted Sleep and Two Nights of 8 Forced Awakenings — 1276.25…
N/A N=79 Effect of Ketamine on Opioid-Induced Hyperalgesia
Pain · Chronic Pain · Hyperalgesia
Primary: Change in Temperature of Pain Threshold — -0.02; -0.61; -0.61; -0.77 Degrees Celsius — p=0.274
N/A N=56 Dyspareunia and Central Sensitization
Endometriosis · Central Sensitisation · Dyspareunia
Primary: Deep Dyspareunia Score — 3.08 scores on a scale
N/A N=180 Effect of Butorphanol Combined With Flurbiprofen Axetil on Preventing Hyperalgesia Induced by Remifentanil in Patients
Pain · Anesthesia
Primary: Mechanical Hyperalgesia Threshold on the Dominant Inner Forearm — 60.57; 78.29; 68.50; 79.7 g
N/A N=31 Study To Assess The Reproducibility And Sensitivity Of Quantitative Sensory Testing In Patients With Neuropathic Pain
Neuropathic Pain
Primary: Mean Change From Baseline in Dynamic Allodynia Intensity at Visits 3 and 6 and Visits 4 and 7 — -1.09; -1.16; -1.31; -0.67 scores on a scale — p=0.7319
N/A N=150 Effect of Dexmedetomidine Combined With Low-dose Nalmefene on Preventing Remifentanil-induced Postoperative Hyperalgesia
Pain · Anesthesia
Primary: Mechanical Hyperalgesia Threshold on the Dominant Inner Forearm — 61.5; 88.2; 73.0; 67.2 g
N/A N=22 Nociceptive Pain Fiber Response
Painful Peripheral Diabetic Neuropathy
Primary: Changes in Small Nerve Fiber Density by Assessment of a Skin Biopsy Comparing Baseline to Day 60 — .1; .1 nerve fibers / mm squared
Phase 4 N=20 The Effect of Intranasal Oxytocin on Pain Sensitivity and Threshold
Healthy
Primary: Hot and Cold Thermal Sensory Threshold for Pain at Baseline in Degrees Celsius. — 43.93; 43.0; 14.81; 13.33 degrees Celsius — p=.47
N/A N=34 Exercise-induced Hypoalgesia After Comparative Forms of Exercise
Pain
Primary: Change in Pain Intensity Ratings (0-100 Pain Scale) — 33.5; 46.2; 40.2 scores on a scale
N/A N=60 The Effects of Intensity on Exercise-Induced Hypoalgesia During a Knee Extension Exercise
Healthy
Primary: Pressure Pain Threshold — 19.11; 48.22; -4.14 kilopascals
Phase 3 N=125 A Study of Sativex® for Relief of Peripheral Neuropathic Pain Associated With Allodynia.
Pain · Peripheral Neuropathy
Primary: Change From Baseline in the Mean Daily Peripheral Neuropathic Pain on a 0-10 Numerical Rating Scale Score During the Last Seven Days of Treatment (End of Treatment)…
N/A N=10 N-of-few Study of Pain Perception
Healthy
Primary: Within Participant Subjective Ratings of Acute Thermal Pain Following High Compared to Low Cues (Learned Via Symbolic Learning) — 7.32 score on a scale — p=0.043
N/A N=30 Subcutaneous Botulinum Toxin for Cutaneous Allodynia
Pain
Primary: Time Until Analgesic Failure — 76.3; 79 Days
Phase 3 N=60 Evaluation of the Effect of Ketamine on Remifentanil-induced Hyperalgesia
Pain · Hyperalgesia · Inflammatory Response
Primary: Pain 30 Minutes — 5.5; 6.2 units on a scale — p=0.386
N/A N=113 Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone
Post Operative Pain · Hyperalgesia
Primary: the Extent of Hyperalgesia Area Proximal to Surgical Wound — 19.5; 14.68; 15.28; 11.04 cm
N/A N=7 Opioid Taper Study
Chronic Pain
Primary: Pain Perception Measured Using the Cold-pressor Test (CPT) — 24.01; 42.02 seconds
Phase 2 N=10 Study on the Effect of a Beta Blocker on Increased Sensitivity to Pain in Humans Caused by Opioids
Hyperalgesia
Primary: Percent Change From Baseline in Size (Area) of Secondary Hyperalgesia After Cessation of Remifentanil Infusion, a Measure of Opioid-induced Hyperalgesia (OIH). — -28…
Phase 3 N=246 A Study of Sativex® for Pain Relief of Peripheral Neuropathic Pain, Associated With Allodynia
Pain · Peripheral Neuropathy
Primary: Change From Baseline in Mean Peripheral Neuropathic Pain on a 0-10 Numerical Rating Scale (NRS) Score at the End of Treatment (15 Weeks) — -1.36; -0.84 units on a scale…
Phase 4 N=30 Evaluating the Efficacy and Safety of Extended Release Hydromorphone (Exalgo) in Patients With Neuropathic Pain
Neuropathic Pain
Primary: Change From Baseline in the Average Pain Over the Last 24 Hrs on the Brief Pain Inventory (BPI) Scale — -1.2 units on a scale
Phase 1 N=35 The Efficacy of MK-8291 in Participants With Post-herpetic Neuralgia (PHN) With Allodynia (MK-8291-012)
Postherpetic Neuralgia
Primary: Change From Baseline in Pain Intensity at Week 4 of Each Treatment Period — -1.776; -1.263 Score on a scale — p=0.075
N/A N=200 The Impact of SCN9A Gene Polymorphism on Individual Pain Perception in the General Population
Pain · Surgery
Primary: Opioid Consumption Dose 48h After Operation. — 37.4; 50.4 microgramme
N/A N=10 The Effect of Intravenous Lidocaine on Allodynia
Pain
Primary: Pain Perception — 5.40303; 5.1457; 5.13171 units on a scale
N/A N=85 Neuromodulation of Lidocaine and Capsaicin Cream Effects on Pain Experience
Pain
Primary: Comparison of Functional Connectivity Changes of the DLPFC Before and After tDCS Stimulation — -0.11; -0.09; 0.08; -0.13 Fisher Z value
N/A N=80 Alpha as a Predictive Biomarker
Pain
Primary: Peak Alpha Frequency (Hz) — 10.04 frequency (Hz)
Phase 4 N=421 Pain Increases After Shoulder Injection
Shoulder Pain
Primary: Incidence of a Flare Reaction — 44; 8; 149; 191 Person-visits