N/A N=36 Cannabidiol Effects on Blood Alcohol Level and Intoxication
Alcohol Use Disorder
Primary: Breath Alcohol Concentration (BrAC) — 0.065; .067; .070 g/dL
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 1 N=33 Ability of Partial Inverse Agonist, Iomazenil, to Block Ethanol Effects in Humans
Active Ethanol and Active Iomazenil · Active Ethanol and Placebo Iomazenil · Placebo Ethanol and Active Iomazenil
Primary: Biphasic Ethanol Effects Scale (BAES) — 3.767; 3.935; 3.813; 3.194 score on a scale
Phase 2 N=212 Residual Effects of Intoxication on Student Performance
Alcoholic Intoxication · Neurobehavioral Manifestations
Primary: Self-reported Residual Effects of Heavy Drinking — 4.3; 1.93 scores on a scale
N/A N=112 Impaired Risk Awareness During Intoxication in DUI Offenders
Alcohol Use
Primary: Mean Number of Alcohol Binges — 3.36; 4.05; 2.69; 3.98 Alcohol Binges
N/A N=180 Intravenous Alcohol Administration Using BrAc Method in Healthy Subjects With and Without a Family History of Alcoholism
Alcoholism
Primary: Number of Drinks Felt Consumed at Baseline — 0; 0; 0; 0 drinks felt consumed
Phase 2 N=44 Effect of Varenicline on Fixed-Dose Alcohol Administration in Participants With Alcohol Use Disorders
Alcohol Reactivity
Primary: Cognitive Function as Measured by Omissions on the CPT — 1.78; 1.28; 4.76; 0.98 Number of Omissions
N/A N=10 Combined and Isolated Effects of Sleep Deprivation and Alcohol Intake on Exercise Performance in Humans.
Alcohol Intake · Sleep Deprivation
Primary: Aerobic Performance — 172; 173; 175; 176 bpm
Phase 1 N=34 Mavoglurant in Alcohol Drinking
Alcohol Drinking
Primary: Abnormal Labs and Adverse Events — 9; 8; 0; 0 Participants
Early Phase 1 N=30 Behavior Brain Responses
Alcohol Drinking · Drinking Behavior · Physiological Effects of Drugs
Primary: Change in Subjective Effects as Assessed by Score on "Feel Drug", "Feel High", "Like Drug", and "Want More" Subscales of the Drug Effects Questionnaire Across Sessions…
Phase 1 N=19 Behavioral Effects of Drugs: Inpatient (36) (Alcohol, Duloxetine, and Methylphenidate)
Alcohol Use Disorder
Primary: Reinforcing Effects (Pre-Alcohol Dose Consumption) — 0.005; .01; 0.007; 0.005 Units on a Theoretical Scale
N/A N=44 Satiety and Alcohol Challenge
Alcohol Drinking
Primary: Change in Alcohol Specific Satiety Score — -0.51; 4.85 score on a scale
Phase 4 N=122 Isopropyl Alcohol vs Ondansetron for Nausea in the Emergency Department
Nausea
Primary: Nausea 100 mm Visual Analogue Scale (VAS) — 23; 19; 42 units on a scale
Early Phase 1 N=80 Alcohol, Behavior, and Brain Imaging
Alcohol Drinking · Binge Drinking · Drinking Behavior
Primary: Stop Signal Task (SST) — 255; 215 milliseconds
Phase 2 N=62 Effects of Tolcapone on Decision Making and Alcohol Intake in Alcohol Users
Alcohol Abuse · Impulsive Behavior
Primary: Number of Drinks Consumed in a Laboratory Bar Session — 2.69; 2.96; 2.73; 2.39 drinks
Phase 4 N=15 Effect of Ethanol Intoxication on the Anti-Hypoglycemic Action of Glucagon
Type 1 Diabetes Mellitus
Primary: AOCGIR (Area Over the Curve for Glucose Infusion Rate) — 1996; 1981 mg*minute/dl
Phase 2 N=32 Phase IIa Study of Fomepizole for Acetaldehyde Toxicity After Ethanol Exposure in Subjects With Altered Ethanol Metabolism
Aldehyde Dehydrogenase-2 (ALDH2) Deficiency
Primary: Number of Participants With Adverse Events (AEs), Serious AEs, and AEs Leading to Study Discontinuation — 13; 6; 8; 21 Participants
N/A N=24 Effects of Acetate and Alcohol on Brain Function
Cerebral Blood Flow · Brain Function
Primary: Change in Cerebral Blood Flow as Measured With Arterial Spin Labeling — 31.7; 26.9; 30.0; 25.0 cc/100 mg/min
N/A N=54 Manipulation of Breath Alcohol Tests: Can Specific Techniques Alter Blood Alcohol Concentration Readings?
Alcohol Concentration Values · Alcohol Intoxication
Primary: Percent Alcohol Concentration Measured by Breathalyzer — 0.099; 0.086; 0.099; 0.099 percent Breathalyzed alcohol content — p=<0.0001
N/A N=444 Brief Online Interventions for Alcohol Use
Alcohol Use Disorder
Primary: Alcohol Use — 19.4; 16.3; 15.3; 19.1 percentage heavy drinking days
N/A N=352 Brief Alcohol E-Interventions Study
Alcohol Drinking in College
Primary: Mean Drinks Per Day — .93; 1.15; .86; 1.38 Drinks per day — p=<.05
N/A N=48 Alcohol Impaired Driving in the Natural Environment
Driving Under the Influence
Primary: Alcohol Impaired Driving Behavior — 67; 60; 36; 29 Count of driving episodes after drinking
N/A N=75 Clinical Intervention in Alcohol Use Disorder
Alcohol Use Disorder · Eligible to go Into the MRI Scanner · Short-term Abstinence From Alcohol Use (2 Week Abstinent)
Primary: Intervention Effects on Brain Functional Connectivity — 0.05; 0.19 percentage of Blood Oxygenation Level De
N/A N=20 Evaluating Perceived Fitness to Drive While Intoxicated
Alcohol Drinking · Alcohol Intoxication · Perception, Self
Primary: Participants' Perceived Fitness to Drive Measurement — 6.5; 4.6 units on a scale
Phase 2 N=33 Transcranial Direct Current Stimulation Over Dorsolateral Prefrontal Cortex in Alcoholism
Alcohol Dependence · Executive Dysfunction · Abnormal Craving for Drugs
Primary: Use of Alcohol — 15; 8 participants
Phase 1 N=537 Alcohol Health Education Among College Drinkers
College Student Drinking
Primary: Alcohol Consumption — 16.929; 17.988; 18.039 drinks
N/A N=48 Study of Mobile Phone Delivered Intervention to Reduce Alcohol Consumption
Alcohol Abuse
Primary: Acceptability of Intervention to Patient — 23; 24 Participants
Phase 1 N=11 The Behavioral Effects of Opioids and Alcohol
Opioid Use · Alcohol Drinking
Primary: Peak Subject-Rated Outcome: Visual Analog Scale (VAS) Drug Liking — 12.9; 47.1; 49.9; 54.8 score on a scale
Phase 2 N=9 Oxytocin Treatment of Alcohol Dependence
Alcohol Withdrawal · Alcohol Dependence
Primary: Change in Clinical Institute Withdrawal Assessment for Alcohol (CIWA) Score — -2.76; 1.01 units on a scale
N/A N=9 Genetic and Neural Factors in Alcohol-Related Cognition
Alcohol Abuse
Primary: Changes in Alcohol-influenced Behavior — 1.56; 1.49 units on a scale
Phase 2 N=157 Marijuana's Impact on Alcohol Motivation and Consumption
Alcohol Drinking · Marijuana
Primary: Alcohol Craving — 2.54; 2.64; 2.65; 2.55 units on a scale