N/A N=19 A Comparison of Non-invasive Ventilation Methods Used to Prevent Endotracheal Intubation Due to Apnea in Very Low Birth Weight Infants
Apnea of Prematurity
Primary: Number of Participants Who Were Intubated — 6; 8 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=34 Study of Nasal Ventilation In Preterm Infants To Decrease Time on The Respirator
Bronchopulmonary Dysplasia
Primary: Number of Days Being Intubated — 12.4; 6.2 days
N/A N=1,493 A Trial Comparing Noninvasive Ventilation Strategies in Preterm Infants Following Extubation
Intubated Infants Were Intend to Extubation Using Noninvasive Ventilation Strategies
Primary: Duration of Invasive Mechanical Ventilation — 6.3; 7.8; 7.3 day
N/A N=102 Nasal HFOV Versus Nasal SIPPV in Neonate Following Extubation: RCT Crossover Study
High-Frequency Ventilation · Intermittent Positive-Pressure Ventilation · Newborn Morbidity
Primary: Partial Pressure CO2 (pCO2) : Data From the Crossover Phase of the Study — 38.7; 36.8 mm Hg
N/A N=200 Trial of Non Invasive Ventilation for Respiratoy Distress Syndrome
Prematurity · Respiratory Distress Syndrome
Primary: Need for Endotracheal Ventilation in the First 72 hs of Life — 34; 25 participants — p=<0.05
N/A N=80 Effective Approaches & Strategies to Ease Off Nasal CPAP In Preterm Infants
Neonatal Respiratory Distress Syndrome · Extremely Low Birth Weight Infant (ELBW) · BronchoPulmonary Dysplasia
Primary: Number of Participants With Successful Wean Off CPAP at the First Attempt — 31; 30 Participants
N/A N=77 Non-invasive Ventilation vs Oxygen Therapy After Extubation Failure
Respiratory Failure
Primary: Rate of Intubation — 10; 23 participants
N/A N=52 Extubation Readiness and Neuroventilatory Efficiency After Acute Respiratory Failure
Respiratory Failure
Primary: Neuroventilatory Efficiency (NVE) — 17.6; 39.9 ml/uV — p=<0.05
Phase 3 N=124 NIV Strategies for RDS in Preterm Infants. NIV (Non Invasive Ventilation), RDS (Respiratory Distress Syndrome)
RDS of Prematurity
Primary: Duration of NIV Support — 89; 87 HOURS — p=< 0.05
N/A N=66 A Comparison of Methods of Discontinuing Nasal CPAP in Premature Infants <30 Weeks Gestation
Apnea of Prematurity · Respiratory Distress Syndrome
Primary: Number of Days on NCPAP or Mechanical Ventilation — 17.3; 12.3 days
N/A N=22 Randomized Crossover of NAVA and Synchronized Intermittent Pressure Ventilation in Neonates and Infants
Respiratory Insufficiency · Infant, Newborn, Disease
Primary: Respiratory Severity Score (MAP X FiO2) — 3.83; 3.82; 3.46; 3.86 score on a scale
N/A N=40 Nasal Noninvasive NAVA in the Very Low Birth Weight Infant
Inadequate; Pulmonary Ventilation, Newborn · Infant, Very Low Birth Weight
Primary: Change in Partial Pressure of Carbon Dioxide on Capillary Blood Gas — 0.019 mm Hg
N/A N=751 Protocolized Post-Extubation Respiratory Support Study
Mechanical Ventilation Complication · Acute Respiratory Failure · Intubation Complication
Primary: Reintubation — 57; 52 Participants
Phase 1 N=14 Nasal High Frequency Ventilation in Preterm Infants: A Pilot Study
Infant Respiratory Distress Syndrome · Respiratory Insufficiency · Apnea of Prematurity
Primary: pCO2 Measurements Post-intervention, as Compared to Pre-intervention Values — 50; 45 mm Hg — p=0.011
N/A N=340 NHFOV vs. NCPAP as a Primary Treatment to Neonatal Respiratory Distress Syndrome(NRDS)
Preterm Infants
Primary: Number of Participants Who Required Intubation — 26; 15 Participants
Phase 2 N=24 Randomized Crossover Study of Neurally Adjusted Ventilatory Assist (NAVA) in Preterm Infants
Infant, Preterm
Primary: Peak Inspiratory Pressure — 13.45; 12.45 cmH2O — p=0.043
N/A N=39 A Comparison of Different Ventilation Strategies in Infants Using the PLMA™
Ventilation
Primary: Mean Values of End-tidal Carbon Dioxide and Tidal Volume Compared Between the Spontaneous Ventilation and Pressure Support Ventilation Groups. — 4.5; 7; 51.8; 49 cc/kg
N/A N=67 Extubation With or Without Spontaneous Breathing Trial
Respiratory Failure
Primary: Number of Participants With Successful Extubation, Reintubation and in Hospital Mortality — 28; 29; 3; 3 participants — p=>0.05
N/A N=32 Effort of Breathing Guided Ventilator Protocol
Ventilators, Mechanical · Work of Breathing
Primary: Percentage of Protocol Recommendations Which Are Accepted by the Clinical Provider — 76 percentage adherant
Phase 1 N=30 Extubation Advisor: Initial Implementation and Evaluation of a Novel Extubation Clinical Decision Support Tool
Airway Extubation
Primary: Evaluate Feasibility of Enrolling and Consenting Greater Than 50% of Eligible Patients — 30 Participants
N/A N=26 Volume Guarantee Ventilation in Preterm Infants With Frequent Episodes of Hypoxemia
Episodic Hypoxemia in Mechanically Ventilated Preterm Infants
Primary: Percentage of Time Spent With Arterial Oxygen Saturation < 75% — 5; 4.4 % of time — p=0.44
Phase 2 N=149 Aerosolized Surfactant in Neonatal RDS
Respiratory Distress Syndrome, Newborn
Primary: Number of Participants With Adverse Events as a Measure of Safety and Feasibility — 3; 8; 4; 12 Participants
Phase 4 N=61 Randomized Controlled Trial of Surfactant Delivery Via Laryngeal Mask Airway (LMA) Versus Endotracheal Intubation
Respiratory Distress Syndrome, Newborn
Primary: Rate of Failure of Surfactant Therapy, Either Early (Need for Mechanical Ventilation Within 1 Hour), or Late (FiO2 > 0.60 to Maintain Target SpO2, or Second Dose of…
Phase 3 N=477 Comparison of Aerosol Delivery of Infasurf to Usual Care in Spontaneously Breathing RDS Patients
Respiratory Distress Syndrome
Primary: Intubation and Instillation of Liquid Surfactant — 69; 120 Participants
N/A N=1,512 Tracheal Intubation Coaching in NICUs
Failed or Difficult Intubation, Sequela · Intubation;Difficult · Intubation Complication
Primary: Number of Participants With Tracheal Intubation Associated Events (TIAEs) in the NICU Over 2 Years — 138; 214; 33; 51 Participants — p=0.015
Phase 3 N=1,032 Newborn Ventilation in the Delivery Room: Could it be Improved With a T-piece Resuscitator?
Resuscitation
Primary: Proportion of Infants With a HR ≥ 100 Bpm at 2 Minutes of Life. — 93.7; 88; 93 percentage of participants
N/A N=269 Evaluation of a Systematic Approach to Weaning From Mechanical Ventilation
Weaning Failure · Complication of Respirator [Ventilator]
Primary: Mortality — 10; 14 participants — p=0.03
N/A N=32 Non Invasive Ventilation as Airway Clearance in Patients With Cystic Fibrosis
Cystic Fibrosis
Primary: Lung Function: Lung Clearance Index — 9; 9.7 lung clearance index
N/A N=19 Non-invasive Intervention for Apnea of Prematurity
Apnea of Prematurity · Hypoxia · Bradycardia
Primary: Change in Total Number of Episodes of Apnea/Breathing Pauses During Intervention and Without Intervention — 284.13; 174.27 breathing pauses
N/A N=3,003 Impact of Heart Rate Characteristics Monitoring in Neonates
Sepsis
Primary: Number of Ventilator-free Days — 95.9; 93.6 days — p=0.08