N/A N=43 Metabolic Parameters 3 Months, 9 Months, and 2 Years After Bariatric Surgery
Obesity · Diabetes · Heart Failure
Primary: Change in Weight — -21.5; -16.4 kg — p=<.0001
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=15 High-fat Meal Challenge in Pediatrics
Pediatric Obesity · Insulin Resistance
Primary: Palatability of the High Fat Agent. — 13 Participants — p=0.15
Early Phase 1 N=46 Assessment of Renal Function by Multiparametric MRI
Renal Impairment
Primary: T1 Time — 1500 ms
N/A N=10 Evaluation of the CapScan Device to Measure the Metabolism of Sulfasalazine
Healthy
Primary: Regional Collection of Metabolites and Gut Microbiota — 10 participants with sulfasalazine detected
Phase 2 N=13 Energy Metabolism in Thyroidectomized Patients
Thyroid Goiter · Hypothyroidism · Thyroid Cancer
Primary: Short Term Change in Weight — 1.7; -0.76 Kilogram
N/A N=16 Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
Nutritional and Metabolic Diseases
Primary: Number of Test Results Outside the Normal Range — 6; 3; 0; 0 participants
N/A N=22 Measuring Fatty Acid Oxidation in Cerebral Metastases Using [18F]FPIA
Cerebral Metastases
Primary: Quantitative Measurement of [18F]FPIA Uptake Within the Cerebral Metastases of Treatment naïve Patients. — 1.54; 1.47; 1.48 SUV_max (kBq/L/kBq/g)
N/A N=36 Exercise,Metabolic Syndrome and Weight Regain (Echocardiography Substudy)
Metabolic Syndrome · Obesity
Primary: Mean Resting E/E' — 7.01 ml/min/kg — p==0.14
Phase 2 N=12 Evaluation of 3-V Bioscience-2640 to Reduce de Novo Lipogenesis in Subjects With Characteristics of Metabolic Syndrome
Metabolic Syndrome
Primary: Change in Hepatic Lipogenesis — 5.6 abs percent change fasting lipogenesis
N/A N=20 Hepatic Mitochondrial Function in Youth
Hepatic Steatosis · Bariatric Surgery Candidate · Adolescent Obesity
Primary: Change in Percentage of Liver Fat Per MRI — -13.93 percentage of liver fat
N/A N=87 Assessment of Energy Balance
Caloric Intake and Energy Metabolism
Primary: ENERGY BALANCE EQUATION, PHASE I, ONE SUB-STUDY — 2360; 2208; -152 kCal
Phase 2 N=61 Heart Rate Variability in Response to Metformin Challenge
Fibromyalgia · Mitochondrial Diseases · Movement Disorders
Primary: Heart Rate Variability (Time Domain) — 0.92; 0.83 msec/msec — p=0.77
N/A N=8,493 Monitoring and Management for Metabolic Side Effects of Antipsychotics
Mental Health · Psychotic Disorders
Primary: Change in Site-level Rates of Weight Monitoring at Baseline (Within 30 Days of a New Antipsychotic Prescription) — 1811; 1410; 1598; 1109 Participants
Phase 2 N=20 EPI-743 for Metabolism or Mitochondrial Disorders
Mitochondrial Disease · Neurology · Myopathy
Primary: Newcastle Paediatric Mitochondrial Disease Scale (NPMDS) Part I-III, Baseline — 23.9; 20.4 Units on a scale
Phase 2 N=11 Fat Malabsorption in Chronic Pancreatitis
Chronic Pancreatitis
Primary: Malabsorption Blood Test: Difference in Mean HA AUC Between Groups: Subjects With CP Compared to Healthy Subjects — 8.3; 17.7 mg*h/dL — p=<0.001
N/A N=30 Nutritional Biomarkers of Sarcopenia
Sarcopenia
Primary: Resting and Maximum Plasma Leucine Concentration — 659; 755; 721; 95 micromoles per liter
N/A N=8,584 Low Indexes of Metabolism - Information to Teams (LIMIT)
Weight Loss · Thinness · Malnutrition
Primary: Death From Any Cause — 285; 245 Participants
N/A N=164 Determining Metabolic Effects of Valproate and Antipsychotic Therapy
Schizophrenia
Primary: Change From Baseline in Total Body Fat Composition Using Dual Energy X-ray Absorptiometry at 12 Weeks — -0.51; 2.03 percent change — p=< 0.0001
N/A N=10 Novel Approach to Assess Metabolic Flexibility in a Respiratory Chamber
Diabetes Mellitus, Type 2
Primary: Overnight Respiratory Exchange Ratio — 0.832; 0.887 ratio
N/A N=47 Females, Aging, Metabolism, and Exercise
Obesity
Primary: Change in Physical Activity Energy Expenditure (PAEE) — 74.5; -10.2; 61.0 kcal/day
Phase 4 N=54 Metabolic Analysis for Treatment Choice in Gestational Diabetes Mellitus
Gestational Diabetes · Diabetes, Gestational · Pregnancy in Diabetes
Primary: Proportion of Women Who Are Eligible, Screened, Enroll and Remain in the Study — 25; 26 Participants — p=0.9
N/A N=54 Food Intake Response to Short-Term Modifications of Metabolism in Humans
Healthy Volunteers
Primary: 24-hour Energy Expenditure (kcal) — 2256; 2166; 2563; 2487 kcal
N/A N=21 Effects of Low Fat Versus Low Carbohydrate Diets on Energy Metabolism
Healthy · Healthy Volunteers
Primary: Ad Libitum Energy Intake — 2752; 2063 kcal per day
N/A N=349 In Vitro Fertilization Impact on Metabolic Parameters
GDM · Insulin Resistance · Glucose Intolerance
Primary: Short-term Effect of Fertility Medications on Glucose Homeostasis and Insulin Resistance in Patients Undergoing IVF Treatment — 87.62; 82.19; 9.37; 9.45 mg/dL
Phase 4 N=20 Metabolic Abnormalities in HIV-infected Persons
Lipodystrophy · HIV Infection
Primary: Change in Insulin Sensitivity From Baseline to Week 12 Post-treatment With Insulin Sensitizing Agent — -0.25; -0.96 mg/kg lean body mass/min
Phase 2 N=39 Comparison of EPA and DHA-Rich Fish Oils on Lipoprotein Metabolism In Adults
Lipoprotein Metabolism · PCSK9 · Proteomics
Primary: Plasma PCSK9 Levels at Baseline and End of 6 Week Intervention — 13.30; 14.11; 12.44 ng/mL
N/A N=18 A Novel Positron Emission Tomography (PET) Approach to Measuring Myocardial Metabolism
Type 2 Diabetes Mellitus
Primary: Myocardial Fatty Acid Uptake Rate — 18.492; 2.123; 36.005; 7.8 umol/min/100g
N/A N=32 Metabolomics of Insomnia-Related Hyperarousal
Primary Insomnia
Primary: Number of Metabolites Elevated Relative to the Other Group. — 13; 9 Number of metabolites elevated
N/A N=27 Metabolic Study of Sleep Apnea in Men and Women
Obstructive Sleep Apnea (OSA)
Primary: Polysomnography - Apnea-hypopnea Index (AHI) — 11.4; 0.7; 6; 1.1 units on a scale
N/A N=142 Evaluation of Microcirculatory Function and Mitochondrial Respiration After Cardiovascular Surgery
Shock · Cardiovascular Diseases · Critical Illness
Primary: Perfused Vessel Denisty (PVD) — 22.8; 23.8; 20.2; 22.5 mm/mm^2