N/A N=80 Mother-Infant Psychoanalysis Project of Stockholm
Mother-infant Relational Disturbances
Primary: The Parent-Infant Relationship Global Assessment Scale (PIR-GAS; ZERO-TO-THREE, 2005) — 83.53; 76.67 Scores on a scale — p=.006
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=54 Behavioral Change in the Mother-Infant Dyad: Preventing Postpartum Depression
Postpartum Depression
Primary: Hamilton Rating Scales of Depression — 12.09; 17.17 units on a scale — p=.01
N/A N=42 Mommy-Baby Treatment for Perinatal Depression
Depressive Disorder, Major · Postpartum Depression
Primary: Change in Edinburgh Depression Scale From Baseline — 17.81; 17.9; 12.04; 11.41 units on a scale
N/A N=368 Reducing Maternal Depression and Promoting Infant Social-Emotional Health & Development
Maternal Depression and Parent Practices, Postpartum · Infant Development
Primary: PHQ9 — 11.94; 10.31; 5.61; 5.33 score on a scale — p=0.503
N/A N=252 Collaborative Perinatal Mental Health and Parenting Support in Primary Care
Parenting · Mother-child Relations
Primary: Change in Parent Sensitivity in Teaching — 36.73; 35.32 score on a scale — p=.026
N/A N=93 Preschooler Emotion Regulation in the Context of Maternal Borderline Personality Disorder
Borderline Personality Disorder · Emotional Problem
Primary: Maternal Emotion Dysregulation — 82.35; 91.8 score on a scale — p=.002
Phase 2 N=100 Brief Intervention in At-Risk First-time Mothers
Substance Use
Primary: Alcohol Use — 1.37; 0.92 units on a scale
N/A N=38 Attachment and Biobehavioral Catch-up and Depression Treatment
Maternal Depression · Child Behavior Problem
Primary: Change in Patient-Reported Outcomes Measurement Information System (PROMIS) Depression Score — 6.70; 6.98 units on a scale — p=.85
N/A N=47 Stage I Randomized Trial of Mentalization-Based Therapy for Substance Using Mothers of Infants and Toddlers
Maternal Substance Use · Child Abuse and Neglect
Primary: Maternal Capacity for Reflective Functioning (Assessed With the Parent Development Interview) — 3.59; 3.08; 3.54; 3.47 units on a scale
N/A N=426 A Randomized Controlled Trial to Improve Mother-Infant Synchrony Among Women With Childhood Adversity
Parent-Child Relations · Maternal Behavior · Infant Behavior
Primary: Mother-Infant Synchrony, Gaze and Affect — 113.89; 106.72; 28.2; 16.1 seconds of synchrony
N/A N=55 Listening Visits for Emotionally Distressed Mothers of Hospitalized Newborns
Nurse Delivered Counseling · Emotional Distress
Primary: Mean IDAS-GD Score at 4 Weeks (End of Treatment) and 8 Weeks (Follow up) — 46.12; 51.10; 40.11; 42.39 score on a scale — p=<0.05
N/A N=152 Sleep Disruption in New Mothers: An Intervention Trial
Pregnancy · Postpartum Period · Sleep Disturbance
Primary: Maternal Sleep Quantity (Objective) — 6.1; 6.6 hours
N/A N=175 PREPP: Preventing Postpartum Depression
Postpartum Depression (PPD)
Primary: Score on the Edinburgh Postnatal Depression Scale (EPDS) — 5.04; 4.36; 4.43; 4.04 score on a scale
N/A N=72 Evaluation of a Novel Intervention for Infants At Risk for Neurodevelopmental Disorders
Autism Spectrum Disorder · Neurodevelopmental Disorders
Primary: Change in Mean Percent of Parent Child Dyadic Engagement Over Time From Baseline to Posttest 1 — 22.01; 16.91; 26.55; 27.09 percent time in dyadic engagement — p=0.028
N/A N=42 Attachment and Biobehavioral Catch-up for Depression
Depressive Symptoms · Anxiety Symptoms
Primary: Change From Baseline in Internalizing Subscale Score of the Child Behavior Checklist (CBCL) at Week 10 (Value at Baseline Minus Value at Post Intervention (Week 10))…
N/A N=24 MUMMIBODIES. Eating Disorders, Pregnancy and Post Partum Period.
Mental Health Disorder · Eating Disorders · Pregnancy Related
Primary: Number of Participants With Each Type of Personal Features Associated With Worsening or Relapse of Eating Disorder Symptoms During Pregnancy (Time Point 1) — 5; 3; 3; 4…
N/A N=36 Neurophysiology of Postpartum Depression in an Experimental Model of Pregnancy and Parturition
Postpartum Depression
Primary: Blood-oxygen-level-dependent (BOLD) Response During Functional Magnetic Resonance Imaging (fMRI) z Statistic — 2.3; 2.0; 2.1; 1.7 z score — p=.27
N/A N=74 Intranasal Oxytocin and Maternal Neglect
Maternal Behavior
Primary: Differences in Brain Activation (Blood Oxygen Level Dependent [BOLD] Signal) of Dopamine Reward Regions and Prefrontal Cortex After Intranasal Oxytocin Administration in…
N/A N=1,200 Happy Mother-Healthy Baby: An Anxiety-focused Early Prenatal Intervention
Postpartum Depression · Small for Gestational Age at Delivery · Preterm Birth
Primary: Number of Participants With Combined Common Mental Disorders (CMDs, i.e. Anxiety and Depression). — 57; 178 Participants
N/A N=68 Therapist Education and Massage for Parent Infant-Outcomes
Parent-Child Relations · Parents · Extreme Prematurity
Primary: Percent of Eligible Dyads Who Would Consent to Enroll (Recruitment) — 91 percentage of participants
N/A N=10 Holding, Stress, and Bonding During Therapeutic Hypothermia
Hypoxic-Ischemic Encephalopathy
Primary: Frequency of Adverse Events (Safety) — 0 Participants
N/A N=130 Maternal Role in Oral Feed Establishment in Preterm Neonates
Preterm Birth · Tube Feeding · Swallowing Disorder
Primary: Transition Time to Full Oral Feeding — 10; 9 days
N/A N=96 Cognitive Behavioral Couple Therapy for Perinatal Distress
Perinatal Depression · Perinatal Anxiety
Primary: The Sum of Scores of Major Depressive Disorder Subscale and Generalized Anxiety Disorder Subscale — 18.14; 17.31; 15.62; 8.62 score on a scale — p=0.000
N/A N=247 Supporting Parents Program: Intervention for Families in CPS
Child Abuse · Child Neglect
Primary: Child Welfare Outcomes: CWS Removal From Birth Parent Home — 7; 16 participants — p==.043
N/A N=71 Learning to Love Mealtime Together
Infant Obesity · Parenting · Feeding Behavior
Primary: Infant Weight-for-Length Z Scores — 0.43; 0.12 z-score — p=0.07
N/A N=210 Effects of Maternal Interpretation Biases on Child Anxiety and Related Responses
Anxiety Disorders
Primary: Word Sentence Association Paradigm — 0.37; 0.52; 0.27 units on a scale
N/A N=146 Infant and Parent Shared Book Reading
Individual, Category, and No-label Conditions
Primary: Infant Visual Attention — .533; .358; .377; .544 Proportion of Visual Attention Duration — p==.002
N/A N=630 Maternal Adversity, Vulnerability and Neurodevelopment
Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse) · Infant Development · Infant Behavior
Primary: Child's Cognitive Development Measured Using the Bayley Scales of Infant Development II. — 524; 508; 458; 422 Participants
N/A N=120 Personalized Integrated Chronotherapy for Perinatal Depression
Depression · Postpartum Depression · Prenatal Disorder
Primary: Change in Depressive Symptoms — 1.6; 2.2 units on a scale
N/A N=21 A Prenatal Bonding Intervention for Pregnant Women With Depression
Depression · Pregnancy
Primary: Change on Maternal Antenatal Attachment Scale (MAAS) — 69.7; 72.4; 75.9 score on a scale