Clinical Trial Search

Primary: Mean of the Change in Morphine Dosage (in mg) Required to Achieve 25% Reduction in Thermal Evoked Pain Responses Relative to Baseline (Pre-intervention) Placebo…

Primary: Overall Maximum Self-reported Pain Score — 8; 8 units on a scale

Primary: Change in Pain Level — 1.15; -0.04; 1.07 score on a scale

Primary: the Extent of Hyperalgesia Area Proximal to Surgical Wound — 19.5; 14.68; 15.28; 11.04 cm

Primary: Hydromorphone Use at 24 Hours — 4.56; 9.9 milligrams

Primary: Pain Reduction at 60 Minutes (Baseline Pain Score - Pain Score at 60 Minutes) — 3.95; 3.95 units on a scale

Primary: Pain Score at Rest — 165.5; 218.2; 233.8 score on a scale×hr

Primary: Pain Threshold — 18.72; 24.78; 16.16; 24.37 seconds

Primary: Proportion of Non-Responder (NR) Participants — 14; 18; 14; 11 participants

Primary: Opioid Consumption During the 48 Hours After Surgery — 51; 87 mg — p=0.0072

Primary: Total Opioid Consumption in the Postoperative Period — 8; 14 milligrams

Primary: Post-operative Morphine Consumption — 54.6; 44.8 mg — p=0.5

Primary: Duration of Intrathecal Fentanyl Analgesia — 70; 63 Minutes — p=0.54

Primary: Overall Opioid Dose (Morphine-equivalent Dose in mg) — 19.6; 19.6; 19.6 mg

Primary: Postoperative Pain Control — 4.5; 1.6; 1.75; 2.75 score on a scale

Primary: Analgesia — 36.3; 71.8 units on a VAS scale — p=0.097

Primary: Satisfaction With Pain Relief — 8.70; 8.85 score on a scale — p=0.70

Primary: Morphine Consumption in the First 48 Hours After Surgery — 309; 195 mg

Primary: Pain Perception Measured Using the Cold-pressor Test (CPT) — 24.01; 42.02 seconds

Primary: Post-operative Opioid Consumption (mg/kg) — 0.267; 0.340 mg/kg — p=<0.05

Primary: Brief Pain Inventory Score — 8; 6.7 score on a scale

Primary: Amount of Pain Experienced — 28; 35 Score on a scale

Primary: Change in Pain Threshold Time From Baseline to Week 5 — 2.95; -3.49 seconds

Primary: The Percentage of Patients Requiring at Least One Medical Intervention for Respiratory Events — 16; 29 Participants — p=<0.05

Primary: Postoperative Pain After Cardiac Surgery — 2.28; 2.17 units on a scale

Primary: Hot and Cold Thermal Sensory Threshold for Pain at Baseline in Degrees Celsius. — 43.93; 43.0; 14.81; 13.33 degrees Celsius — p=.47

Primary: Dose of IT Morphine and IT Hydromorphone for Adequate Analgesia (Pain Score Less Than or Equal to 3) in 90% of Patients — 75; 150 micrograms

Primary: Milligrams of Intravenous Morphine Used by Participant in First 24 Hours Postoperatively — 18; 14; 15 Milligrams

Primary: Opioid Consumption — 24; 38; 24; 27 oral morphine mg equivalents (OME)

Primary: Pain Rating — 7.36; 5.61; 7.54; 6.75 units on a scale — p=<0.001