N/A N=98 Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation
Mild Cognitive Impairment · Metabolic Syndrome
Primary: MoCA (Montreal Cognitive Assessment) — 28.38; 20.22 score on a scale — p=<0.0001
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=41 Olfactory Deficits in MCI as Predictor of Improved Cognition on Donepezil
Mild Cognitive Impairment
Primary: Selective Reminding Test (SRT) — 33.61; 36.23; 36.81; 37.13 Words
N/A N=107 Promoting Adaptive Neuroplasticity in Mild Cognitive Impairment
Mild Cognitive Impairment · Alzheimer's Disease
Primary: Face-name Memory Test Performance — -.28; -.01; -1.29; -1.76 pairs correctly recalled/recognized
N/A N=33 Memory Consolidation in Obstructive Sleep Apnea
Obstructive Sleep Apnea
Primary: Overnight Change in Declarative Memory Performance — 11.2; 6.5 percent change in performance
N/A N=50 Wayfinding Intervention in High-Fidelity Long-Term Memory
Long-Term Memory Decline · Mild Cognitive Impairment
Primary: MDT Change in Mnemonic Discrimination — 0.09; 0.01 LDI score on a scale — p== 0.016
Phase 1 N=52 Behavioral and Neuroimaging Changes After Cognitive Rehab in Traumatic Brain Injuries (TBI) and Mild Cognitive Impairment (MCI)
Mild Cognitive Impairment · Alzheimer's Disease · Traumatic Brain Injury
Primary: Memory Test Accuracy on Trained Stimuli — 53.9; 37.6; 48.9; 37.3 Percent correct
Phase 4 N=157 The Efficacy of Phosphatidylserine-Omega3 in Elderly With Age Associated Memory Impairment
Age Associated Memory Impairment
Primary: Change From Baseline in Rey Auditory Verbal Learning Test — 1.53; 1.00; 5.30; 4.02 number of words correctly recalled
Early Phase 1 N=35 Remediation of Impaired Self-Regulation in Patients With Mild TBI
Mild Traumatic Brain Injury
Primary: Blood Oxygen Level Dependent (BOLD) Brain Signal Measured Using Functional MRI. — 270; 111 voxels — p=<0.0001
Phase 4 N=61 Combination Treatment Study for Memory Impairment and Depression
Depression · Mild Cognitive Impairment
Primary: Selective Reminding Test (SRT) Total Recall — 45.6; 46.6 Words
N/A N=68 Mild Cognitive Impairment and Obstructive Sleep Apnea
Obstructive Sleep Apnea · Mild Cognitive Impairment
Primary: Hopkins Verbal Learning Test-Revised (HVLT-R) — 23.52; 20.04; 23.68; 20.39 score on a scale
N/A N=78 Semantic Memory, Financial Capacity, and Brain Perfusion in Mild Cognitive Impairment (MCI) (CASL)
Alzheimer Disease · Dementia
Primary: FCI Score at Follow-up — 147.3; 164.0; 123.3; 150.8 points awarded for correct items
N/A N=68 Everyday Memory Intervention
Aging
Primary: Everyday Memory Failures — 0.55; 0.62 average daily number memory failures/day — p=.67
N/A N=59 Brain Plasticity Underlying Acquisition of New Organizational Skills in Children
ADHD · Attention Deficit Hyperactivity Disorder · Neurodevelopmental Disorders
Primary: Change in the Intrinsic Functional Connectivity (iFC) Between Dorsal Anterior Cingulate Cortex (dACC) and Default Mode Network Subdivision of the Anterior Ventral…
Phase 4 N=121 Olfactory Deficits and Donepezil Treatment in Cognitively Impaired Elderly
Alzheimer Disease · Mild Cognitive Impairment · Delirium, Dementia, Amnestic, Cognitive Disorders
Primary: Change Over Time in Selective Reminding Test (SRT) Scores — 36.14; 21.19; 39.99; 24.10 Words
Phase 2 N=31 Memory and Insulin in Early Alzheimer's Disease
Alzheimer's Disease
Primary: fMRI Measure of Hippocampal Activation — 36.4; 41.3 percentage of active voxels
Phase 2 N=175 Efficacy And Safety Of CX516 In Elderly Participants With Mild Cognitive Impairment.
Mild Cognitive Impairment
Primary: 15-Item Word List Delayed Recall — -0.3; -0.5 units on a scale - change from baseline — p=<.05
Phase 2 N=113 Nutraceutical Effects on Long-Term Memory
Aging
Primary: Delay Eyeblink Conditioning — 52.32; 56.88 percentage of conditioned responses
N/A N=59 Mnemonic Strategy Versus Spaced Retrieval Training in Those With Mild Cognitive Impairment
Mild Cognitive Impairment
Primary: Percent of Correct Object Location Associations Assessed up to 1 Month Post-treatment — 80.0; 62.45 percent correct — p=<.001
Phase 2 N=30 Intranasal Inhalations of Bioactive Factors Produced by M2 Macrophages in Patients With Organic Brain Syndrome
Organic Brain Syndrome, Nonpsychotic · Neurocognitive Disorders · Mental Disorder, Organic
Primary: The Number of Patients With Severe Adverse Events and Adverse Reactions — 0 Participants
N/A N=107 Cognitive Training and Neuroplasticity in Mild Cognitive Impairment
Mild Cognitive Impairment · Memory Disorders · Memory Impairment
Primary: Change in the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) — -0.89; 0.55 score
N/A N=81 Memory and Fear Study (Fear of Memory Loss Study)
Anxiety and Fear
Primary: Fear and Avoidance of Memory Loss (FAM) Scale Score at Follow-up — 63.9; 60.3 score on a scale
N/A N=76 Methylphenidate (Ritalin) and Memory/Attention in Traumatic Brain Injury (TBI)
Brain Injury
Primary: Neuropsychological Assessment, CVLT-II — 51.3; 51.8; 51.9; 57.2 units on a scale — p=<0.04
Phase 2 N=30 The Efficient Brain Study
Metabolism - Cerebral Energy
Primary: Magnetic Resonance Spectroscopy (MRS) Will Measure a Change in Cerebral Energy Function in Brain Tissue — .011; .007; .009; .006 Difference in metabolite amplitude
N/A N=146 Cognitive Training and Practice Effects in Mild Cognitive Impairment
Mild Cognitive Impairment
Primary: Auditory Memory Attention Index — 89.0; 94.3 standard score units — p=<0.01
Phase 4 N=18 The Efficacy of Phosphatidylserine-Omega3 in Elderly Subjects With Memory Impairment
Memory Impairment
Primary: Change From Baseline in Neuropsychological Computerized Test — 3.16; -2.38; 1.88; 4.50 Points on a scale
Phase 2 N=19 CDP-Choline and Working Memory After TBI: A Neuroimaging Study
Brain Injuries
Primary: Cognitive Composite Score for Group of Subjects With TBI and Healthy Controls Matched by Age, Education, and Treatment Group. — 42.750; 50.500; 49.500; 55.000 T-score…
N/A N=156 A Mobile Informatics Solution to Aid in Memory
Alzheimer Disease · Dementia
Primary: PWMC Loneliness — 4.90; 5.28 units on a scale
N/A N=104 Improvisational Movement for People With Memory Loss and Their Caregivers
Alzheimer's Disease (Incl Subtypes) · Dementia · Mild Cognitive Impairment
Primary: Quality of Life in Alzheimer's Disease (QOL-AD)--Participants With Dementia (PWD) — 35.42; 38.10; 35.56; 36.12 score on a scale
Phase 2 N=80 Metformin in Amnestic Mild Cognitive Impairment
Mild Cognitive Impairment
Primary: Change in Total Recall Score in the Selective Reminding Test — 5.7; 9.4 score on a scale — p=0.05
N/A N=58 Project IMPACT: Improving Memory Performance by Applying Cognitive Training
Cocaine Use Disorders · HIV
Primary: Working Memory Assessed by Domain Deficit Score — .29; .21; .14; .26 Score on a scale — p=0.039