Phase 4 N=14 Imaging of Osteonecrosis With Ferumoxytol-Enhanced MRI
Osteonecrosis
Primary: Signal to Noise Ratio (SNR) — 33.82; 129.56 dB — p=0.002
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=110 Efficacy of Zoledronic Acid in Preventing Collapse of the Osteonecrotic Femoral Head
Avascular Necrosis of Femoral Head
Primary: Number of Participants With Femoral Head Collapse Within 24 Months — 29; 22 participants
Phase 4 N=24 Management of Mandibular ORN: PENTO as Medical Treatment
Osteoradionecrosis
Primary: Bone and/or Tissue Healing as Measured With the Classification of ORN Stages, Area of Bone Exposed (mm2) and Radiological Findings (OPG). — 14; 15; 13; 15 mm2
Phase 4 N=6 Bone Histomorphometry in Postmenopausal Men and Women With Osteoarthritis Undergoing Total Hip Replacement
Osteoporosis
Primary: Percentage of Participants With Modeling Based Bone Formation in the Femoral Neck — 100 percentage of participants
Phase 2 N=117 OZONE_EXO: Comparative Analysis of Protocols for Dental Exactions in Patients at Risk of MRONJ: Case-control Study
MEDICATION RELATED OSTEONECROSIS OF THE JAW
Primary: Healing Evaluation Using Inflammatory-Proliferative-Remodelling Scale (IPR Scale): Inflammatory Phase — 2; 2.49 score on a scale
Phase 2 N=51 Hypertension Intervention to Reduce Osteonecrosis in Children With Acute Lymphoblastic Leukemia/Lymphoma
Hypertension · Osteonecrosis · Osteonecrosis Due to Drug
Primary: Extensive Radiographic Osteonecrosis — 20; 21; 1; 2 Participants — p=0.7139
N/A N=25 Effect of Intraarticular Steroids on Bone Turnover in Osteoarthritis
Osteoarthritis
Primary: Change in Serum Osteocalcin — -2.18; -0.45; -1.10 ng/mL
N/A N=68 Ceramic-on-ceramic THA for Post-traumatic Hip Osteoarthritis After Acetabular Fracture
Hip Osteoarthritis · Post-traumatic Osteoarthritis
Primary: Survival Rates of the Hip Implants — 96.3 percentage of non-revised implants
Phase 2 N=29 Study to Assess Safety and Clinical Activity of Local MBN-101 in Treatment of Infected Bone Sites
Bacterial Infection
Primary: Number of Participants With Adverse Events — 5; 4; 1; 6 participants
N/A N=117 Heterotopic Ossification Prophylaxis
Acetabular Fracture · Heterotopic Ossification
Primary: Number of Participants With Severe HO Formation — 3; 9 Participants
N/A N=62 DePuy Trochanteric (ATN) Nailing Clinical Outcomes Trial
Femoral Fracture (Proximal)
Primary: Success in Terms of the Merle D'Aubigne Postel Score for Pain Category — 4.1; 4.4; 4.5; 4.6 Units on a scale
Phase 2 N=332 Study To Assess FRacTure Healing With SclerosTin Antibody - Hip
Fracture Healing
Primary: Timed-Up-and-Go (TUG) Over Week 6 Through Week 20 — 54.1; 41.0; 47.2; 53.3 seconds — p=0.1983
N/A N=29 OsteoStrux™ Collagen Ceramic Scaffold in Instrumented Lumbar Spine Fusion
Degenerative Changes · Stenosis · Spondylosis
Primary: Number of Posterolateral Gutters That Have Evidence of Arthrodesis (Fusion) at 3, 6, 12, and 24 Months, as Measured by X-rays. — 39; 34; 42; 36 Posterolateral Gutters
Phase 4 N=36 Denosumab to Prevent High-Turnover Bone Loss After Bariatric Surgery
Bariatric Surgery Candidate · Bone Loss
Primary: Percentage Change in Total Hip Bone Mineral Density — 0.60; -6.44 percentage of change
Phase 2 N=57 The Effect of Glitazone Treatment on Bone Marrow and Bone Marrow Cells
Change in Bone Mineral Density · Change in Bone Marrow Fat Content
Primary: Difference in Percent Change in Bone Mineral Density (BMD) From Baseline to 14 Weeks Between the Rosiglitazone Group and the Placebo Group — -1.3; 0.3 Percent change…
Phase 3 N=7 Investigating the Use of Prolia (Denosumab) in the Treatment of Acute Charcot Neuroarthropathy
Charcot Joint of Foot
Primary: Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability] — 0; 7 Participants
N/A N=22 Prevention of Post Operative Bone Loss in Children
Osteoporosis · Cerebral Palsy · Spina Bifida
Primary: Amount of Bone Density Lost (%) From pre-to Post-operative DXA Scan — 0.043; -0.025 percent change
N/A N=206 OsteoCool Tumor Ablation Post-Market Study
Metastasis Spine · Metastasis to Bone
Primary: Change of Worst Pain Score: Thoracic/Lumbar Spine RF Ablation — -4.1 units on a scale — p=<0.0001
Phase 2 N=1,457 A Long-Term, Placebo-Controlled X-Ray Study Investigating the Safety and Efficacy of SD-6010 in Subjects With Osteoarthritis of the Knee
Osteoarthritis
Primary: Rate of Progression of Joint Space Narrowing — -0.101; -0.125; -0.109 mm/year — p=0.508770
N/A N=101 Role of Bone in Knee Osteoarthritis (OA)
Osteoarthritis, Knee
Primary: Number of Participants With Viable Specimens for Genetic Analysis — 14 participants
N/A N=15 Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee
Osteochondritis Dissecans
Primary: Greater Cartilage Healing Measured by Glycosaminoglycan Content on dGEMRIC MRI
N/A N=63 Comparison of Ozone and Steroid Injection in Patients With Greater Trochanteric Pain Syndrome
Trochanteric Bursitis
Primary: Pain Severity — 8.36; 8.17 score on a scale
N/A N=23 Skeletal Muscle Atrophy and Dysfunction Following Total Knee Arthroplasty
Knee Osteoarthristis
Primary: Cross-sectional Area (CSA) of Muscle Fibers — 2680; 2377; 2028; 1882 micron squared
N/A N=38 Geniculate Artery Embolization for Treatment of Osteoarthritis
Osteoarthritis
Primary: Percentage Change in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) - Pain Score — -50.1 Percentage change
N/A N=262 Acinetobacter Baumannii-related Osteomyelitis: Clinical and Epidemiological Characterization
Osteomyelitis
Primary: Description of the Clinical and Epidemiological Profile of Patients With Infection — 92; 26; 25; 21 Participants
N/A N=39 Glucocorticoids and Bone in Graves' Ophthalmopathy
Graves Ophthalmopathy
Primary: Percent Change Lumbar Spine Bone Mineral Density — 1.37 Percentage change
N/A N=50 Osteoarthritis Structural Changes Assessed by Magnetic Resonance Imaging and Neuropathic Pain in Knee Osteoarthritis
Neuropathic Pain · Knee Osteoarthritis
Primary: Osteoarthritis Structural Changes Assessed by Quantitative Magnetic Resonance Imaging With and Without Neuropathic Pain — 14; 7; 5; 1 participants
N/A N=10 Effect of Thiazolidinediones on Human Bone
Osteoblast · Adipocytes · Bone Density
Primary: Percent Change in Number of Osteoblast and Adipocyte Colony Forming Units Cultured From Bone Marrow Stem Cells Harvested 6 Months After Treatment With Study Drug…
N/A N=85 Long-term Outcomes of Conical Tapered Stems in Cementless Total Hip Arthroplasty Due to Congenital Hip Pathologies
Dysplasia; Hip · Prosthesis Survival
Primary: Harris Hip Score — 89.8 points
Phase 3 N=627 Tanezumab in Osteoarthritis Of The Hip
Arthritis · Osteoarthritis · Osteoarthritis, Hip
Primary: Change From Baseline in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale Score at Week 16: Baseline Observation Carried Forward…