Phase 2 N=31 Capnometry-Assisted Breathing Training for COPD
Chronic Obstructive Pulmonary Disease
Primary: Number of Participants With Adherence to Home Breathing Exercises — 10; 5 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=92 Determinants of Age Related Breathing Instability During Non-Rapid-Eye-Movement (NREM) Sleep
Sleep Apnea · Age
Primary: Apneic Threshold (AT) and Carbon-dioxide (CO2) Reserve — 39.8; 36.7; -4.1; -2.6 mm Hg — p=<0.05
N/A N=21 Modified Adaptive Servoventilation (ASV) Compared to Conventional ASV
Periodic Breathing · Breathing-Related Sleep Disorder
Primary: Apnea/Hypopnea Index (AHI) — 3.9; 6.4 Events per hour — p=0.022
N/A N=7 Assessing Variability of the Ventilatory Response to Duffin's Rebreathing Procedure
Ventilation · Reproducibility · Physiology
Primary: Baseline Minute Ventilation — 11.6; 12.0 L/min
N/A N=40 Sleep Apnoea Breathing Record Exploratory Study (SABRES)
Sleep Apnea
Primary: Correlation Between the Trial Device and an Established Device — 0.955 correlation coefficient
N/A N=92 Respiratory Dysregulation and Breathing Training in Anxious Outpatients
Anxiety
Primary: Episodic Anxiety Scale — 8.1; 9.0; 14.3 units on a scale
N/A N=63 Neonatal Resuscitation - Sustained Inflations
Premature Birth
Primary: Expiratory Tidal Volume — 153; 194 ml/kg/min
N/A N=25 Servo-Ventilation In-lab PSG Evaluation
Sleep Apnea Syndromes
Primary: Average Apnea Hypopnea Index Among Different Polysomnography Devices. — 18.4; 25.4; 24.1; 19.2 events per hour
Phase 3 N=119 Reducing Dynamic Hyperinflation Through Breathing Retraining
Pulmonary Disease · COPD
Primary: Exercise Duration (Time Walked on the Constant Workrate Treadmill Test) — 15.2; 17.6 minutes — p=0.63
N/A N=17 Slow Yogic-Derived Breathing and Respiration and Cardiovascular Variability in Spinal Cord Injury Patients
Spinal Cord Injuries · Slow Breathing
Primary: HRV — 1421; 813; 3173; 2819 ms^2
N/A N=99 A Home-based Intervention to Promote Mindful Breathing Awareness Through Pursed-lip Breathing Training for COPD Patients
Chronic Obstructive Pulmonary Disease
Primary: Breathlessness — 0.68; 0.71; 0.34; 0.83 score on a scale
N/A N=29 Acute Intermittent Hypoxia and Breathing in Neuromuscular Disease
Amyotrophic Lateral Sclerosis (ALS) · Neuromuscular Diseases
Primary: Percent Change in Maximal Inspiratory Pressure (MIP) — 0.3; -3.1; -4.8; -5.0 percentage change in MIP from baseline
N/A N=36 Evaluation of an Algorithm to Detect Sleep and Wake in Continuous Positive Airway Pressure (CPAP)
Sleep Apnea, Obstructive
Primary: Sleep/Wake Algorithm — 62 accuracy (%)
N/A N=43 Auto-PAP Therapy For Improved Fetal Growth
Obstructive Sleep Apnea · Pregnancy
Primary: Number of Participants With Slowing of Fetal Growth by 33% or More During the Last Trimester — 8; 8 Participants — p=0.92
N/A N=80 Sustainability of Pulmonary Rehab Gains
COPD
Primary: Duration of Exercise Time on a Constant Work-rate Treadmill Test — 12.2; 12.5 change in number of minutes walked — p=0.94
N/A N=42 Capnography-Assisted Learned Monitored (CALM) Breathing Therapy for COPD
COPD
Primary: Mean Attendance Rate of CALM Breathing Treatment Sessions — 84.2 percentage of completed sessions
N/A N=19 Non-invasive Intervention for Apnea of Prematurity
Apnea of Prematurity · Hypoxia · Bradycardia
Primary: Change in Total Number of Episodes of Apnea/Breathing Pauses During Intervention and Without Intervention — 284.13; 174.27 breathing pauses
N/A N=22 Non-invasive Ventilation System in Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)
Pulmonary Disease, Chronic Obstructive · Airflow Obstruction, Chronic · Chronic Obstructive Airway Disease
Primary: Device Tidal Volume — 180 mL
N/A N=100 Oxygen Monitoring of Patients After Surgery on the Hospital General Care Floor
Sleep Disordered Breathing
Primary: Number of General Care Floor Patients Exhibiting a Saturation Pattern Detection (SPD) Alert. — 74 participants
N/A N=59 Modulation Of Airway Reactivity With Chronic Mechanical Strain
Asthma
Primary: Change in Airway Reactivity From Baseline (Visit 1) and 4 Weeks (Visit 2) — 3.0; 3.2; 5.3; 4.3 mg/mL
N/A N=17 Evaluating the Influence of Apnea on Cardiac Function Using Cardiac Magnetic Resonance Imaging.
Physiological Changes in Deliberate Apnea
Primary: Cardiac Function: Duration of Apnea — 483 sec
Phase 4 N=14 Sleep and Breathing in the General Population - Chemical Stimuli
Sleep-disordered Breathing
Primary: The Central Apnea-hypopnea Index — 14.1; 29.9 events per hour
N/A N=29 Bipap Automatic Servo Ventilation (autoSV) Advanced in Central Apnea Patients
Cheyne-Stokes Respiration · Sleep Apnea, Central
Primary: Apnea/Hypopnea Index (AHI) — 55; 37; 12 Apnea-Hypopnea events per hour
N/A N=25 Vitabreath Pilot in Chronic Obstructive Pulmonary Disease (COPD) Patients
COPD · Dyspnea
Primary: Average Distance During Modified 6 Minute Walk Test — 128.0; 129.9; 137.5; 121.3 meters — p=0.02
N/A N=41 Respiration Validation for CPM Device
Cardiopulmonary Disease
Primary: Accuracy of CPM System Calculated RR Versus Reference Device Via Percent of Error Accuracy of Respiration Rate — 99.1; 98.5 Percent
N/A N=34 Positive Airway Pressure Program
Sleep Apnea, Obstructive
Primary: Participant Providing Feedback — 26 Participants
N/A N=21 Adjustment of Mask Pressure, for Bilevel Positive Airways Pressure Therapy, by Automated Algorithm
Respiratory Insufficiency · Sleep Disordered Breathing
Primary: Index of Apneoas Plus Hypopnoeas Per Hour of Sleep (AHI) — 1.3; 1.7 Events per hour of sleep
Phase 2 N=22 Abnormal Ventilatory Response to Carbon Dioxide: a Potential Biomarker for Seizure Induced Respiratory Depression & Modification by SSRI
Epilepsy · SUDEP
Primary: Study Recruitment Rate — 3.8 participants/3 months
N/A N=44 Breathe: Slow Paced Breathing to Lower Blood Pressure
High Blood Pressure
Primary: Breathing Rate — 9.4; 13.7 Breaths/minute
N/A N=115 Comparison of Breathing Event Detection by a Continuous Positive Airway Pressure Device to Clinical Polysomnography
Sleep Apnea
Primary: Apnea-hypopnea Indices (AHI) as Determined by Polysomnography (PSG) vs Automatic Event Detection (AED ) Algorithm — 5.6; 5.8; 2.4; 3.2 events per hour — p=0.007