N/A N=34 Investigation of the Safety and Efficacy of Pocket-X Gel
Periodontal Pocket
Primary: Change in Periodontal Pockets Probing Depth — 6.97; 6.81; 7.67; 7.72 mm
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=602 Periocline as an Adjunct to Scaling and Root Planing for Adult Periodontitis
Adult Periodontitis
Primary: Change in Pocket Depth. — -1.4; -1.6; -1.4 mm
Phase 3 N=39 Collection of Gingival Crevicular Fluid From Periodontitis Patients
Gingival Diseases
Primary: Metabolite Associated With Inflammation (Cadaverine) — 1.119186; 0.92077 ion count — p=<0.05
N/A N=60 Activated MMP-8 as Diagnostic Test for Periodontitis
Generalized Chronic Periodontitis
Primary: Percentage of True Positive/Negative aMMP-8 Tests of All Periodontitis Patients (Sensitivity/Specificity) — 87; 60 percentage of true cases (sens./spec.)
Phase 2 N=151 Safety, Efficacy and Treatment Regimen Study of ST266 in Subjects With Moderate to Severe Periodontitis
Periodontal Disease
Primary: Changes in Pocket Depth (PD) for Those Pockets ≥ 6 mm at Baseline — 6.6; 6.6; 6.7; 4.5 Pocket Depth (mm) — p=0.341
Phase 4 N=51 Effects of AMP Application After Non-surgical Periodontal Therapy on Treatment of Periodontitis
Periodontitis
Primary: Periodontal Probing Depth — 2.5; 3.2; 3.4 millimeter
N/A N=5,117 Periodontal Disease Prevention Study
Periodontitis
Primary: Percentage of Participants With Tooth Loss Over 16 Year Period — 16.4; 13.8; 22.1; 16.9 percentage of participants
N/A N=30 Implant Surface Decontamination in Peri-implantitis Treatment
Peri-implantitis · Periodontal Disease
Primary: Change in Total Bacterial Load on the Exposed Implant Surface — 2.77; 4.21 log (colony forming units/ml)
N/A N=69 IFI16 is a Periodontitis Modulating Protein
Severe Periodontitis · Acute Inflammatory Response
Primary: Change in Absent in Melanoma 2 (AIM2) mRNA Expression Levels — 0.37; 0.65 fold change — p=0.3
Phase 4 N=49 Compare Anti-inflammatory Dentifrices
Gingivitis
Primary: Gingival Index (GI) — 1.04; 1.01 units on a scale — p=<0.05
N/A N=20 Comparison of Autogenous Periosteal Pedicle Graft and Collagen Membrane in Management of Periodontal Intrabony Defects
Chronic Periodontitis
Primary: Clinical Attachment Level — 6.42; 6.15; 3.52; 3.6 mm
N/A N=23 Clinical Evaluation of Laser Therapy Used as an Adjunct to Non-Surgical Treatment of Gum Disease
Periodontitis Chronic Generalized Moderate · Periodontitis Chronic Generalized Severe
Primary: Probing Pocket Depth — 4.167; 4.273 mm
N/A N=41 Clinical and Radiographic Evaluation of Demineralized Freeze-Dried Bone Allograft Versus Platelet Rich Fibrin for the Treatment of Periodontal Intrabony Defects in Humans
Periodontitis
Primary: Change in Clinical Attachment Level (CAL) — 1.21; 1.03 mm
Phase 2 N=146 Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers
Periodontitis · Periodontal Diseases
Primary: Change in Mean Clinical Attachment Level. — 0.11; 0.10; 0.21; 0.08 mm — p=>0.05
N/A N=40 Platelet-rich Fibrin and Connective Tissue Graft in Recession Treatment
Gingival Recession
Primary: Vertical Recession — 3.35; 3.20; 0.38; 0.65 mm — p=0.259
N/A N=34 Effect of Non-surgical Periodontal Therapy on Gingival Crevicular Fluid Interleukin-21 Levels
Chronic Peridontitis Patients · Chronic Gingivitis · Healthy
Primary: Pocket Depth — 1.60; 2.50; 6.75 millimetres
Phase 3 N=102 Periodontal Infection and Endothelial Dysfunction
Periodontitis
Primary: Brachial Artery Flow-mediated Dilation — 10.2; 10.3; 13.1; 8.1 Percentage of dilatation of brachial art — p=0.98
N/A N=59 Study to Compare Laser Assisted New Attachment Procedure (LANAP) to Traditional Treatments of Chronic Periodontitis
Chronic Periodontitis
Primary: Gain in Clinical Attachment Level of Periodontal Tissues — 1.361; 2.387; 1.180; 2.329 mm
Phase 4 N=56 Clinical and Microbiologic Outcomes of aPDT in the Non-surgical Treatment of Implant Inflammation
DENT IMPLANTS · LASER
Primary: Mean Probing Pocket Depth — 4.62; 4.45 millimeters
N/A N=40 Clinical and Microbiologic Outcomes of Adjunctive Antimicrobial Photodynamic Therapy in the Non-surgical and Surgical Treatment of Teeth With Periodontal Disease
Periodontal Diseases
Primary: Change in Number of Bleeding Sites (Bleeding On Probing) — -1.60; -1.40 bleeding sites
N/A N=32 Induced Gingivitis & Intra-oral Imaging
Plaque Induced Gingivitis
Primary: Change From Baseline Gingivitis at Day 14 as Measured by Non-invasive Microimaging and Gingival Index. — 0.6; 0.15 units on a scale
N/A N=44 Impact of Debridement Invasiveness on Attachment Gain After Antiinfective Periodontal Therapy
Periodontitis · Periodontal Attachment Loss · Periodontal; Lesion
Primary: Change in Clinical Attachment Loss — -1.08; -1.22 mm
N/A N=51 Kidney and Periodontal Disease Study
Chronic Kidney Disease · Periodontal Disease
Primary: Number of Participants Completing Study Protocol — 17; 34; 14; 30 Participants
Phase 2 N=38 Short-term Effect of 2% Atorvastatin Dentifrice in Periodontal Status.
Chronic Periodontitis
Primary: Change in Periodontal Inflammation Surface Area (PISA) — 638.16; 288.72 square millimeters
N/A N=28 Use of Platelet Rich Fibrin in Addition to CAF and SCTG for Treatment of Gingival Recession
Gingival Recession
Primary: Recession Depth — 2; 2; 0; 0 length in millimeters
Phase 4 N=50 Effect of Locally-Applied Simvastatin on Clinical Attachment Level and Alveolar Bone in Periodontal Maintenance Patients
Periodontal Diseases
Primary: Change in Clinical Attachment Level (CAL) — 7.0; 6.9 millimeters
Phase 4 N=70 Scaling and Root Planing (SRP) With and Without Minocycline HCl Microspheres, 1 mg
SRP · Minocycline HCl Microspheres · Biomarkers
Primary: Bacteria Load (log10) — -11.3; -10.9 log 10 copies/mL
N/A N=20 Single Stage Root Coverage for Gingival Recession With or Without Free Gingival Graft
Gingival Recession
Primary: Recession Height — 1.0; 0.9 mm
Phase 4 N=43 Alterations of GCF Levels of Sclerostin and DKK-1 in Postmenopausal Osteoporosis
Osteoporosis, Postmenopausal · Periodontitis
Primary: Sost Values for 6th Month — 1389.177; 1085.405; 1596.585; 2131.87 ng/ml — p=<0.01
Phase 3 N=290 The Efficacy and Safety of Chlorhexidine Gluconate Chip (PerioChip®) in Therapy of Peri-implantitis
Peri-Implantitis
Primary: Absolute Change in Mean Probing Pocket Depth for Selected Target Implants — -1.69; -1.51 mm — p=0.1159