Phase 4 N=30 Peripheral Nerve Blocks for Above-the-knee Amputations
Peripheral Vascular Diseases · Hyperglycaemia (Diabetic) · Hypertension
Primary: Peripheral Nerve Block Success as a Primary Anesthetic — 1 Participants
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Phase 4 N=52 Ultrasound Guided Distal Peripheral Nerve Blocks and Postoperative Pain.
Postoperative Pain
Primary: Proportion of Patients Who Experienced Moderate to Severe Pain During First and Second Postoperative Day — 8.3; 80.8; 4.2; 42.3 percentage of patients
Phase 4 N=85 Perineural Steroids for Peripheral Nerve Blocks
Osteoarthritis, Knee
Primary: Duration of Sensory Nerve Block — 37.00; 31.75; 29.67 hours
Phase 4 N=100 Single Shot Versus OnQ Pump in Extremity Fractures
Pain · Fracture
Primary: Change in Score on Visual Analog Scale (VAS) — 3.28; 1.47; 3.62; 3.91 score on a scale
Phase 4 N=165 Peripheral Nerve Blocks vs Periarticular Local Anesthetic Injection for Total Knee Arthroplasty (TKA)
Total Knee Arthroplasty
Primary: Maximum Pain Post-Operative Day (POD) 1 (Morning) — 3; 4; 4.5 units on a scale — p=0.144
N/A N=7 Percutaneous Peripheral Nerve Stimulation (Neuromodulation) for Postoperative Analgesia
Postoperative Pain
Primary: Change From Baseline of Surgical Site Pain Level (NRS) at Rest [Percentage of Baseline Pain] — 64; 100; 55; 69 percentage of baseline
Phase 4 N=24 Optimizing Local Anesthetic Concentration for Continuous Popliteal-Sciatic Nerve Blocks
Relatively Healthy Volunteers
Primary: Maximum Tolerance to Transcutaneous Electrical Stimulation — 27.0; 26.9 mA (milliamperes) — p=0.02
N/A N=70 Comparing Through-the-Needle With Suture-Method Catheter Designs for Popliteal Nerve Blocks
Regional Anesthesia · Sciatic Nerve Block
Primary: Average Pain — 2.7; 3.4 score on a scale
N/A N=70 Perineural Local Anesthetic Administration With a Continuous Infusion Versus Automatic Intermittent Boluses
Pain, Acute · Anesthesia, Local · Trauma Injury
Primary: Average Pain Queried on First Postoperative Day — 3; 0.0 score on a scale — p=0.033
N/A N=30 A Comparison of Postoperative Analgesic Nerve Block Ropivacaine Concentrations
Total Hip Arthroplasty · Postoperative Pain
Primary: Opiate Consumption Postoperatively — 8.21; 8.02 mg
Phase 4 N=115 Systemic Steroids for Peripheral Nerve Blocks
Osteoarthritis, Hip
Primary: Duration of Sensory Blockade — 18.5; 18.1; 19.6 hours
Phase 4 N=119 Pectoralis Block vs Paravertebral Nerve Blocks for Breast Surgery
Breast Surgery
Primary: Recovery Room Numeric Rating Scale Pain Scores — 3.3; 1.3 score on a scale
N/A N=16 Thermal-Imaging Comparison of Nerve Blocks for Bilateral Mastectomy
Anesthesia, Conduction
Primary: Skin Temperature Increase From Baseline — 1.9; 2.3 degrees C
Phase 4 N=104 Liposomal Bupivacaine Interscalene Nerve Block in Shoulder Arthroplasty
Arthropathy Shoulder
Primary: Patient Pain Scores — 4.0; 2.8 score on a scale — p=.0197
N/A N=1,623 Comparative Effectiveness of Peripheral Nerve Blocks for Outpatient Shoulder Surgery
Postoperative Complications
Primary: Postoperative Complication — 130; 23; 20; 12 Participants
Phase 4 N=24 Continuous Adductor Canal Nerve Blocks: Relative Effects of a Basal Infusion v. Hourly Bolus Doses
Healthy Human Volunteers
Primary: Tolerance to Cutaneous Electrical Current — 26.6; 27.1 mA
N/A N=30 The Effect of Interscalene Peripheral Nerve Block With 0.25% Bupivacaine vs 0.125% Bupivacaine on Lung Function
Diaphragm Paralysis
Primary: Abnormal Lung Function — 11; 3 participants w/ abnormal diaphragm fxn
Phase 4 N=50 Optimizing Local Anesthetic Concentration for Continuous Lumbar Plexus Nerve Blocks
Hip Arthroplasty · Hip Pain
Primary: Percent Change From Baseline in Quadriceps Femoris Maximum Voluntary Isometric Contraction (MVIC) — 64.1; 68 percentage change from baseline of MVIC
Phase 4 N=100 Serratus Plane Versus Paravertebral Nerve Blocks for Breast Surgery
Breast Surgery
Primary: Mean/Median Numeric Rating Scale Pain Score Within the Recovery Room — 4; 0 score on a scale — p=0.001
Phase 4 N=144 Treating Phantom Limb Pain Using Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study
Phantom Limb Pain
Primary: "Average" Phantom Limb Pain Intensity 4 Weeks Following Initiation of an Ambulatory Continuous Peripheral Nerve Block (as Measured by the Numeric Rating Scale Within the…
N/A N=75 Motor-Sparing Peripheral Nerve Blockade Facilitates Mobility Post Total Knee Arthroplasty: A Randomized Controlled Trial
Arthroplasty, Replacement, Knee
Primary: Pain Measurement Via VAS (Visual Analog Scale) — 4.11; 4.68; 4.36 score on a scale
N/A N=80 Saphenous Nerve Block for Foot and Ankle Surgery
Saphenous Nerve Block
Primary: Block Success — 18; 22 participants — p=0.25
Phase 4 N=114 Effects of Catheter Location on Postoperative Analgesia for Continuous Adductor Canal and Popliteal-Sciatic Nerve Blocks
Post-surgical Pain · Total Knee Arthroplasty · Foot/Ankle Surgery
Primary: Pain (Average): Numeric Rating Scale for Pain — 0.5; 3.0 score on a scale
Phase 1 N=90 Prolonged Popliteal Fossa Nerve Blockade (Prolonged Pop)
Postoperative Pain
Primary: Numeric Rating Scale (NRS) Pain Score With Movement — 1.9; 1; 1.3 units on a scale
N/A N=1,821 Multicenter Continuous Peripheral Nerve Block Surveillance Study
Postoperative Pain
Primary: Complications of Peripheral Nerve Block — 7; 14 participants — p=<0.05
N/A N=65 Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation: A Department of Defense Funded Multicenter Pilot Study
Rotator Cuff Repair · Anterior Cruciate Ligament Reconstruction · Ankle Arthrodesis or Arthroplasty
Primary: Opioid Consumption During First Postoperative Week — 5.0; 47.5 mg
N/A N=60 Saphenous Nerve Block vs. Femoral Nerve Block for Total Knee Arthroplasty
Difference Between Femoral Nerve Block and Saphenous Block
Primary: Visual Analogue Scale Pain Score — 2.81; 2.47 units on a scale
N/A N=32 Evaluation of Continuous Saphenous Nerve Block to Supplement a Continuous Sciatic Nerve Block After Ankle Surgery
Orthopedic Surgery of Lower Extremity
Primary: Verbal Pain Scores — 4.2; 5.4 units on a scale
N/A N=72 Pudendal Nerve Block in Vaginal Surgery
Nerve Block · Pain, Postoperative · Pelvic Floor Disorders
Primary: Visual Analog Scores at 7am After Surgery — 29.2; 42.6 score on a scale
Phase 2 N=192 Periarticular Injection Versus Peripheral Nerve Block in Total Hip Arthroplasty
Hip Arthropathy
Primary: Daily Opioid Consumption — 29.3; 30.8; 49.6; 51.8 milligram — p=0.69