Phase 4 N=343 PAIN - Postoperative Analgesia INvestigation
Postoperative Pain
Primary: Postoperative Pain as Assessed by a Numeric Pain Scale (NPS) — 5.05; 5.02 units on a scale — p=0.934
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=200 Non-invasive Assessment of Immediate Postoperative Analgesia Using Analgesia/Nociception Index (ANI)
Postoperative Pain
Primary: Analgesia/Nociception Index (ANI) — 73; 49 units on a scale
N/A N=122 Protective Analgesia for Postoperative Pain Relief Following Day Case Oral Surgery
Postoperative Pain · Wisdom Tooth
Primary: Number of Patients Needing Rescue Medication — 32; 29 Participants
Phase 3 N=204 Study to Evaluate Postoperative Analgesia in Subjects Undergoing Hemorrhoidectomy
Hemorrhoids
Primary: Area Under the Curve (AUC) of the Numeric Rating Scale at Rest (NRS-R) Pain Intensity Scores — 359; 396 Units on a scale*hours
Phase 3 N=234 OxyNorm Capsules in Post-Operative Pain Study
Postoperative Pain
Primary: Visual Analogue Scale (VAS) in Resting Stage at 6hour (6hour±20 Minutes After Administration of First Dose) — 46.21; 45.48; 20.21; 19.94 units on a scale
N/A N=122 Percutaneous Auricular Neuromodulation for Postoperative Analgesia
Postoperative Pain, Acute
Primary: AVERAGE Pain Measured With the Numeric Rating Scale First 5 Postoperative Days — 1; 3 units on a scale
N/A N=90 Analgesia After Total Hip Arthroplasty: Peri-Articular Injection Versus Epidural Patient Controlled Analgesia (PCA)
Osteoarthritis
Primary: Time Until Patient is Ready for Discharge — 2.4; 2.3 days
Phase 4 N=180 IV Acetaminophen for Post-Operative Pain Management in Enhanced Recovery After Surgery (ERAS) Population
Abdominal Wall Hernia · Pancreatic Diseases · Bowel Disease
Primary: Postoperative Pain Intensity — 33; 42 Participants
Phase 4 N=100 Multimodal Versus Opioid aNalgesia in carDiAc Surgery
Postoperative Pain · Postoperative Delirium
Primary: Postoperative Pain After Cardiac Surgery — 2.28; 2.17 units on a scale
Phase 2 N=86 The Influence of Postoperative Analgesia on Systemic Inflammatory Response and POCD After Femoral Fractures Surgery
Postoperative Cognitive Dysfunction
Primary: Interleukin-6 Concentration in Peripheral Blood. — 27.2; 26.6; 104; 97.7 pg/ml
Phase 2 N=39 Intraoperative Nitrous Oxide and Postoperative Pain for Patients With Current Opioid Treatment
Chronic Pain
Primary: Post-operative Morphine Consumption — 54.6; 44.8 mg — p=0.5
N/A N=98 Compare Preperitoneal Analgesia to Epidural Analgesia for Pain Control After Colon and Rectal Surgery
Colon Cancer · Rectal Cancer · Colonic Diverticulosis
Primary: Postoperative Numerical Pain Score-Day 0 — 3.9; 2.6 units on a scale
N/A N=160 Patient-Driven Analgesic Protocol Selection for Post-Cesarean Pain Management
Postoperative Pain
Primary: Opioid Consumption in the 0-48 Hour Study Periods. — 10; 5; 10; 5 milligram morphine equivalents (MMEQ)
Phase 3 N=72 Postoperative Consequences of Intraoperative NOL Titration
Anesthesia; Adverse Effect
Primary: Pain Scores at 10-minute Intervals for the Initial Hour of Recovery — 0; 0; 1.0; 5.0 score on a scale — p=0.895
Phase 4 N=67 ON-Q Pump Infusion of Ketorolac and Ropivacaine at the Wound Site for Postoperative Pain Management
Postoperative Pain
Primary: Pain Scores at Rest — 6.7; 6.2 units on a scale
N/A N=100 Perioperative Pain Management In Spine Surgery Patients: Part I
Pain
Primary: Immediate Postoperative Pain Control — 6.6; 6.8 score on a scale
Phase 3 N=161 Postoperative Thoracic Epidural Analgesia Versus Intravenous Patient-Controlled Analgesia For Liver and/or Pancreas
Liver Cancer · Pancreatic Cancer
Primary: Postoperative Pain Experience — 78.6; 105.2 score on a scale* hour
Phase 2 N=90 Analgesic Efficacy of Inter Pleural Ropivacaine Road in Post Thoracotomy Pain for Oncologic Surgery
Postoperative Pain · Cancer
Primary: Proportion of Patients With Major Post-operative Pain at Mobilization Following Lung Surgery by Posterolateral Thoracotomy — 4; 3 Participants — p=0.99
N/A N=72 Transversus Abdominis Plane (TAP) Block for Postoperative Analgesia After Laparoscopic Colonic Resection
Colonic Cancer · Rectal Cancer · Colonic Diverticulum
Primary: Morphine Consumption in the First 48hours After the Operation — 47.3; 46.7 mg
Phase 2 N=120 Local Anesthetics on Postsurgical Analgesia Following Posterior Colporrhaphy
Postoperative Pain
Primary: Change in Vaginal Pain Scores Using the Defense and Veterans Pain Rating Scale (Visual Analog Scale) Between Bupivacaine Alone Versus Exparel® Following Posterior…
N/A N=7 Percutaneous Peripheral Nerve Stimulation (Neuromodulation) for Postoperative Analgesia
Postoperative Pain
Primary: Change From Baseline of Surgical Site Pain Level (NRS) at Rest [Percentage of Baseline Pain] — 64; 100; 55; 69 percentage of baseline
N/A N=113 Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone
Post Operative Pain · Hyperalgesia
Primary: the Extent of Hyperalgesia Area Proximal to Surgical Wound — 19.5; 14.68; 15.28; 11.04 cm
Phase 3 N=58 Open-Label Safety and Tolerability Study of Oxymorphone for Acute Postoperative Pain in Pediatric Subjects.
Postoperative Pain
Primary: Summary of Visual Analog Scales (VAS) of Pain Intensity Change From Baseline by Treatment Group With Single Dose of Oxymorphone IR Tablet and Multiple Dose of…
N/A N=280 Individualized Analgesia After Adenotonsillectomy
Analgesia
Primary: The Percentage of Patients Requiring at Least One Medical Intervention for Respiratory Events — 16; 29 Participants — p=<0.05
Phase 4 N=180 Minimal Opioid Use After Total Hip Replacement (THR)
Osteoarthritis, Hip
Primary: Opioid Use — 30; 22.5; 15 Oral Morphine Equivalent (mg)
N/A N=242 Patient Controlled Epidural Analgesia Versus Local Infiltration Analgesia Following Knee Arthroplasty
Osteoarthritis
Primary: Proportion of Patients Discharged From Rehabilitation by Day Four — 77; 82 percentage of patients — p=0.332
Phase 4 N=30 Intraperitoneal Bupivicaine Infusion Using the On-Q Pain Pump After Laparoscopic Surgery
Postoperative Pain
Primary: Visual Aanalog Scale (VAS) for Pain Assessment With Cough at 48 Hours — 1.7; 3.9 units on a scale — p=.0022
N/A N=110 Postoperative Pain Control for Prostatectomy
Prostate Cancer
Primary: Total Milligrams of Opiates — 5.15; 2.52 mg — p=0.0012
Phase 4 N=67 Postpartum Perineal Pain After Obstetric Anal Sphincter Injuries
Pain · Postpartum Depression
Primary: Perineal Pain in Postpartum Patients 1 Week After Obstetric Anal Sphincter Injuries. — 3.5; 2.7; 2.4 score on a scale
N/A N=120 Postoperatory Analgesia After Total Knee Arthroplasty
PAIN
Primary: Postoperatory Analgesia After Total Knee Arthroplasty Comparing Femoral and Sciatic-femoral Block — 2; 2.8; 1.5 units on a scale