Phase 4 N=20 Evaluation Exparel Delivered in Knee Replacement
Arthritis
Primary: Subjective Pain — 3.80; 4.00; 3.44; 5.30 units on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=285 Total Knee Arthroplasty Infiltration Study for Postoperative Analgesia
Postoperative Pain
Primary: Mean Area Under the Curve (AUC) of the Numeric Rating Scale (NRS) Pain Intensity Scores at Rest (NRS-R) Through 48 Hours Postsurgery (AUC0-48). — 386.12; 391.56; 405.82…
Phase 4 N=102 Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty
Osteoarthritis of the Knee
Primary: Pain at Rest (VAS) — 18; 12; 30 Units on a scale — p=0.001
Phase 4 N=99 Efficacy of Ipack Block and Surgeon's Joint Infiltration in Total Knee Arthroplasty
Osteo Arthritis Knee
Primary: Narcotic Consumption — 15.87; 13.67 morphine equivalents, mg
Phase 4 N=78 A Novel Analgesia Technique for ACL Reconstruction
Anterior Cruciate Ligament Injury
Primary: Pain While at Rest — 3.84; 3.95 score on a scale
Phase 4 N=50 Evaluation of Utility of Ultrasound Guided iPACK Block for Knee Extension After Total Knee Arthroplasty.
Knee Osteoarthritis · Primary Total Knee Arthroplasty · Physical Therapy
Primary: Number of Participants Able to Hyperextend the Knee After Surgery — 4; 3 Participants
N/A N=50 Local Injection of Local Anesthetic 24 Hours After Knee Replacement Surgery May Decrease Pain for Several More Hours
Arthroplasty, Knee · Pain
Primary: Pain Assessed Using the VAS 0-10 Pain Scale — 2.763; 2.483 units on a scale
N/A N=96 Arthroscopic Anterior Cruciate Ligament Reconstruction: A Comparison of Three Catheter Placement Positions
Pain, Postoperative
Primary: Pain — 24; 24; 24; 24 participants that experienced pain
N/A N=80 Posterior Capsular Injection With Femoral Nerve Block for Total Knee Arthroplasty
Posterior Knee Infiltration
Primary: Pain Intensity — 3.5; 3.2; 2.1; 1.5 pain score
N/A N=63 Ultrasound Guided Knee Injections in Musculoskeletal Medicine
Knee Osteoarthritis
Primary: Number of Participants With Successful Knee Injection — 17; 14; 13; 7 Participants
Phase 4 N=67 The Role of Intra-Operative Intracapsular Blocks in Post-Operative Pain Management Following Total Knee Arthroplasty
Osteoarthritis
Primary: Numeric Pain Score — 0.67; 1.6; 2.5; 3.6 units on a scale — p=<0.05
Phase 4 N=68 Infrapatellar Nerve Block for Post-operative Knee Arthroscopy Pain Control
Internal Derangement of Knee
Primary: Post op Pain Score — 5.5; 3.9 units on a scale
Phase 4 N=16 Treatment Of Knee Osteoarthritis With Intra-Articular Infliximab
Osteoarthritis of the Knee
Primary: Change in Cellular Infiltrates From Day 0 to Day 28 — 2; 0; 2; 4 Participants
Phase 4 N=174 Block and Periarticular Injection Study
Pain, Postoperative
Primary: Mean Visual Analog Scale (VAS) Pain Score for 2 Weeks Postoperatively — 3.41; 3.27 score on a scale
Phase 4 N=140 Effect of Steroid Injections in a Knee With Osteoarthritis
Osteoarthritis (OA) of the Knee
Primary: Change in Mean Cartilage Thickness in the Index Compartment (Compartment With the Most Damage) — -0.21; -0.10 mm
N/A N=60 Adductor Canal Block for Total Knee Arthroplasty
Arthroplasty, Replacement, Knee · Pain, Postoperative
Primary: 10 Meter Walk Test — 38.6; 49.8; 43.3 Seconds
Phase 4 N=65 Liposomal Bupivacaine for Post Operative Pain After Knee Replacement Surgery
Post-operative Pain
Primary: Pain Intensity at Movement — 8.95; 7.91 VAS Scale
N/A N=76 Do Corticosteroid Injections During Total Knee Replacement Improve Early Clinical Results?
Osteoarthritis · Post-traumatic; Arthrosis
Primary: Length of Hospital Stay — 3.5; 2.6 days
Phase 4 N=101 Periarticular Multimodal Drug Injections in Total Knee Arthroplasty
Osteoarthritis, Knee
Primary: Pain( Visual Analog Scale ) — 2.3; 6.4 units on a scale
Phase 4 N=90 Analgesia After Total Knee Arthroplasty: Peri-Articular Injection Versus Epidural + Femoral Nerve Blockade
Readiness to Discharge
Primary: The Primary Outcome is Time Until a Patient is "Ready for Discharge." — 3.2; 3.2 days
Phase 4 N=50 Continuous Wound Infiltration After Hallux Valgus Surgery
Hallux Valgus
Primary: Average Postoperative Numeric Rating Scale (NRS) for Pain — 2.0; 1.9 units on a scale — p=0.596
N/A N=40 Femoral/Sciatic Block for Knee Surgery
Knee Injuries
Primary: Analgesic Efficacy — 0; 0.1; 0.6; 3.0 units on a scale — p=<0.05
N/A N=160 Efficacy of Multimodal Perioperative Analgesia With Periarticular Drug Injection in Total Knee Arthroplasty(TKA)
Osteoarthritis,Knee
Primary: Numerical Rating Scale (NRS) Pain Scores During Hospitalization. — 1.06; 1.90; 2.67; 1.60 scores on a scale 0-10
Phase 4 N=140 Local Infiltration Analgesia With and Without EXPAREL Following Total Knee Arthroplasty
Pain
Primary: Area Under The Curve (AUC) of Visual Analog Scale (VAS) Pain Intensity Scores From 12 to 48 Hours — 181.523; 208.407 cm*hr — p=0.0381
Phase 4 N=150 Adductor Canal Block for Medial Compartment Knee Arthroplasty
Postoperative Analgesia · Medial Unicompartmental Knee Arthroplasty
Primary: Verbal Pain Scores at 6 Hours Post Nerve Blockade. — 1; 1.1; 1.6; 1.5 score on a scale
N/A N=144 Intra-articular Polyacrylamide Hydrogel in Knee Osteoarthritis
Osteoarthritis
Primary: Change of the Total WOMAC Score (WOMAC-T) — -624.12; -444.82; -605.61; -426.31 score on a scale — p=0.00030
Phase 4 N=86 Adductor Canal Block With Periarticular Injection and IPACK (ACB/PAI/IPACK) Versus Periarticular Injection (PAI)
Knee Arthropathy
Primary: Numeric Rating Scale (NRS) Pain Scores — 5.0; 1.7 score on a scale
Phase 3 N=119 The Analgesic Efficacy of Protocol for Primary Total Knee Arthroplasty (TKA)
Knee Arthroplasty, Total
Primary: Percentage of Patients Presenting With Pain in the Back of the Knee 6 Hours After Surgery — 21.7; 45.8 percentage of patients reporting pain
N/A N=57 Intra-articular Polyacrylamide Hydrogel in the Treatment of Knee Osteoarthritis
Osteoarthritis, Knee
Primary: Change in the Total WOMAC Score (WOMAC-T) — 1137.13; 767.47; 1271.60; 445.33 score on a scale — p=0.00
N/A N=120 Postoperatory Analgesia After Total Knee Arthroplasty
PAIN
Primary: Postoperatory Analgesia After Total Knee Arthroplasty Comparing Femoral and Sciatic-femoral Block — 2; 2.8; 1.5 units on a scale