N/A N=270 The Impact of the COVID-19 (SARS-CoV-2 Disease) on Psychopathology
Psychosis;Schizophrenic · Personality Disorders · Mood Disorders
Primary: Brief Psychiatric Rating Scale (BPRS) — 29.30; 32.80; 30.25 score on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=326 Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders
Tobacco Use Disorder
Primary: Cigarettes Per Day — 22.54; 14.32; 11.76; 7.63 cigarettes per day
N/A N=60 Acute Alcohol Response In Bipolar Disorder: a fMRI Study
Bipolar Disorder · Alcohol Drinking · Alcohol Use Disorder
Primary: Level of Intoxication (Subjective Response) on Each Condition Day After Drinking Relative to How They Felt When Arriving to the Lab on That Respective Day )Prior to…
Phase 2 N=41 PH94B in the Treatment of Adjustment Disorder With Anxiety
Adjustment Disorder With Anxious Mood
Primary: Hamilton Anxiety Scale (HAM-A) Score — -12.5; -12.6 score on a scale — p=0.9338
N/A N=11 Conduct Disorder in Prison: Search for Prospective and Retrospective Recurring and Contextual Elements
Mental Disorders
Primary: The Number of Individuals Diagnosed With Antisocial Personality Disorder in Rochefort Prison With Aberrant Driving Behaviors. — 9 participants
N/A N=28 Event Marker Ingested To Trigger Event Recorder 3.0 Psychiatry Study
Bipolar Disorder · Schizophrenia
Primary: Positive Detection Accuracy — 94 percentage of observed ingestions
N/A N=133 Executive Dysfunction and Suicide in Psychiatric Outpatients and Inpatients
Traumatic Brain Injury · Suicidality
Primary: Iowa Gambling Test — -4.2; 1.7; 3.5; 5.3 Total Raw on a scale from -100 to 100 — p=>.05
Phase 4 N=183 A Collaborative Care Program to Improve Treatment of Depression and Anxiety Disorders in Cardiac Patients
Depression · Generalized Anxiety Disorder · Panic Disorder
Primary: Change in Mental Health-related Quality of Life From Baseline to 24 Weeks — 8.87; 8.39 units on a scale — p=0.002
N/A N=141 Guided Self-help for Common Mental Disorders
Bibliotherapy
Primary: 6-week Change in Kessler 6 Psychological Distress Scale (K6) — -5.68 score on a scale (K6)
Phase 4 N=40 Depression, Epinephrine, and Platelet Function
Major Depressive Disorder
Primary: Response of Participants, Defined by Change in the 21-item Hamilton Depression Rating Scale (HDRS) From Baseline to Week8 — 5; 9; 2; 4 participants — p=.918
N/A N=134 PTSD (PostTraumatic Stress Disorder) Services for Veterans With SMI (Severe Mental Illness)
Post Traumatic Stress Disorder · Schizophrenia · Schizoaffective Disorder
Primary: Posttraumatic Stress Disorder (PTSD) Checklist (PCL) — 66.94; 66.33; 51.20; 60.60 score on a scale
N/A N=60 A Psychotherapy Development Study for Internet Gaming
Internet Gaming Disorder
Primary: Percentage of Participants Who Completed All 6 Sessions — 40.6 percentage of participants
N/A N=10 Network Dysregulation Among Individuals With Comorbid Tinnitus and PTSD
Stress Disorders, Post-Traumatic · Tinnitus
Primary: Change in Score on Clinician Administered PTSD Scale for the DSM-5 (CAPS-5) — 33.10; 16.13 score on a scale — p=0.01
Phase 4 N=8,144 Study Evaluating The Safety And Efficacy Of Varenicline and Bupropion For Smoking Cessation In Subjects With And Without A History Of Psychiatric Disorders
Smoking Cessation
Primary: Occurrence of Neuropsychiatric (NPS) Adverse Events (AE) - the Primary Study Endpoint — 1.3; 2.2; 2.5; 2.4 percentage of participants — p=0.0652
N/A N=45 Transcranial Magnetic Stimulation (TMS) for Motor Symptoms in Psychiatric Disorders
Psychomotor Retardation · Psychomotor Slowing · Schizophrenia and Related Disorders
Primary: Number of Responders at Week 3 — 4; 9; 0; 3 responders
N/A N=300 Psychopathology, Disordered Eating, and Impulsivity as Predictors of Outcomes of Bariatric Surgery
Obesity
Primary: Percent Weight Change — 23.0; 26.2; 23.3 percent weight change
Phase 2 N=58 Oxytocin on Irritability/Emotional Dysregulation of Disruptive Behavior and Mood Disorders
Mood Disorder · Disruptive Behavior Disorders
Primary: Change in Affective Reactivity Index - Youth (ARI-Y) — -2.9; -0.8 score on a scale
Phase 2 N=14 Marinol in Trichotillomania or Obsessive Compulsive Disorder
Trichotillomania · Obsessive Compulsive Disorder
Primary: Massachusetts General Hospital Hairpulling Scale (MGH-HPS) Total Score — 8.71 units on a scale
N/A N=19 PET Imaging and Olanzapine Treatment in Borderline Personality Disorder
Borderline Personality Disorder
Primary: Change in Brain Metabolism From Baseline to Eight Weeks as Seen in PET Scan — 11.5 Standard uptake value — p=<0.05
Phase 3 N=323 An Efficacy and Safety Study of Paliperidone Palmitate in Participants With Schizophrenia
Schizophrenia
Primary: Change From Baseline in the Positive and Negative Syndrome Scale (PANSS) Total Score at Week 13 or Early Discontinuation — 83.5; 85.7; 6.9; -3.1 units on a scale…
N/A N=28 Neurobehavioral Intervention as a Novel Treatment Approach for Emotion-Regulatory Deficits
Anxiety · Depression
Primary: Reaction Time to Facial Affect Identification During Emotional Conflict — 802.15; 889.14; 848.79; 937.97 milliseconds — p=0.004
Phase 2 N=775 Project 3, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Disorders
Tobacco Use Disorder
Primary: Cigarettes Per Day (CPD) — 25.28; 19.95; 17.74 cigarettes per day — p=<0.0001
Phase 2 N=34 Double Blinded, Placebo-Controlled Trial of Paliperidone Addition in SRI-Resistant Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder
Primary: Yale Brown Obsessive Compulsive Scale — 19.14; 21.24 Scores on a scale — p=<0.05
Phase 3 N=75 Aripiprazole for Bipolar Disorder and Alcohol Use Disorder
Bipolar Disorder · Alcoholism · Alcohol Abuse
Primary: Timeline Follow Back (TLFB) — -0.82; -0.71 drinks per drinking day
N/A N=100 Psychosis: Early Detection, Intervention and Prevention
Prodromal Schizophrenia · Psychotic Disorders · Severe Bipolar Disorder With Psychotic Features
Primary: Onset of Psychosis — 10; 14 percentage of sample converting
Phase 4 N=110 Assessing Neuropsychiatric Symptoms Including Depression, Anxiety, Irritability, and Suicidal Thoughts or Behavior in Subjects Quitting Smoking on Varenicline Tartrate or Placebo
Smoking Cessation
Primary: Change From Baseline in the Profile of Mood States (POMS): Total Mood Disturbance (TMD) — 0.06; -0.66; 0.30; -0.17 scores on a scale
N/A N=883 Barriers to Mental Healthcare Utilization in Parkinson's Disease
Parkinson's Disease · Depression · Anxiety
Primary: Most Commonly Reported Past Barrier to Mental Health Services: "Anyone in my Situation Would be Struggling" — 74.8 percentage of total respondents
N/A N=19 Bipolar Disorder in Late Life
Bipolar Disorder
Primary: Boyko DWM Hyperintensity Value >2 in Subjects Who Received Acute Treatment for Mania — 10; 9 participants — p=>0.05
N/A N=37 A Unified Treatment for Anxiety Disorders
Emotional Disorders · Anxiety Disorders
Primary: Anxiety Disorders Interview Schedule for DSM-IV — 5.23; 5.09; 3.18; 5.14 score on a scale
N/A N=36 Reducing Internet Gaming
Internet Gaming Disorder
Primary: Percentage of Participants Who Complete All 6 Sessions — 78.9 percentage of participants