Clinical Trial Search

Primary: Treatment Phase: Drug Liking (Maximum Effect [Emax]) "At This Moment" as Assessed Using Bipolar Visual Analogue Scale (VAS) — 56.7; 57.3; 56.5; 88.5 score on a scale

Primary: Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration — 4.79; 12.83; 11.08; 12.17 units on a scale

Primary: Drug Liking "at This Moment" Visual Analog Scale (VAS) — 54.1; 83.8; 58.9; 58.4 score on a scale

Primary: Number of Self-administered Puffs of Smoked Cannabis Containing Active THC Concentrations Compared to Placebo Under Controlled Laboratory Conditions — 2.00; 2.67; 3.60…

Primary: Change in Mental Health Symptoms — -0.02; 0.11 score on a scale

Primary: Endothelin-1 Levels — 2.15; 2.063; 1.956 pg/ml

Primary: Number of Participants Who Complete the Baseline Assessment — 18 Participants

Primary: The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative — 2.75; 1.38; 1.38; 4.75 cocaine choices

Primary: Emotional Recognition (MDMA) — 55.9 percent intensity

Primary: Alcohol Demand: Breakpoint — -6.00; -2.07; -1.81; -1.09 dollars/drink — p=.26

Primary: Peak Effect of Marijuana Withdrawal — 4.6; 4.1; 2.9; 1.7 units on a scale

Primary: Change in SUbjective Effects as Assessed by Score on "Feel Drug", "Feel High", "Like Drug", and "Want More" Sub-scales of Drug Effects Questionnaire (DEQ). — 19.2; 57.8…

Primary: Alcohol Use, Average # of Drinks Per Week — 11.16; 10.62; 5.16; 3.86 average # of drinks per week

Primary: Feasibility of Retaining Participants in Trial — 100; 86.7 percentage that completed study

Primary: Change in Subjective Effects as Assessed by Score on "Feel Drug", "Feel High", "Like Drug", and "Want More" Sub-scales of Drug Effects Questionnaire (DEQ). — 18.88…

Primary: Drug Liking at .5 Hours — 66.0; 74.7; 47.7; 40.9 score on a scale

Primary: Change in Dopamine Levels at Baseline and After Drug of Dependence Administration as Confirmed by PET Images. — 0.0388; 0.033; 0.0285; 0.0368 mm^3

Primary: Validity of the Marijuana Purchase Task (MPT) — 63 percentage of participants — p=.00000004

Primary: Hamilton Depression Rating Scale (HAMD) Scores — 16.76; 17.65; 1.67; 16.24 score on a scale

Primary: Emax - Maximum Drug Liking — 54.5; 75.0; 72.1; 75.6 score on a scale

Primary: The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative — 0.06; 0.94; 0.75; 0.88 cocaine choices

Primary: Self-Administration of Drug Units Earned — 0.00; 3.83; 3.67; 0.00 Number of drug units

Primary: Simple Reaction Time — .365; .386; .396 Seconds

Primary: Balance of Effects- Drug Liking VAS: Peak Effect (Maximum Effect [Emax]) and Minimum Effect (Emin) — 57.8; 78.6; 82.2; 57.2 mm — p=<0.0001

Primary: Pharmacodynamics (PD): Maximal Effect Score (Emax) of Bipolar Drug Liking Visual Analog Scale (VAS) Scores — 53.0; 85.4; 68.6; 73.3 millimeter (mm)

Primary: Number of Participants With Adolescent and Parent Reported Alcohol, Drug, Vaping and Tobacco Usage — 1; 1; 0; 425 Participants

Primary: Bipolar Visual Analog Scale (VAS) for "Drug Liking" Maximum Effect (Emax). — 54.30; 90.85; 72.53; 76.05 Score on a 100 mm scale — p=<0.0001

Primary: Number of Participants With Risky Sexual Behavior Measured for 1 Year — 143; 155; 162 Participants

Primary: Change in Time Spent in Drug-paired Room — 24.5; 6.2 seconds

Primary: Alcohol Craving — 2.54; 2.64; 2.65; 2.55 units on a scale