Phase 4 N=50 Physiological and Psychological Effects of Testosterone During Severe Energy Deficit and Recovery
Caloric Restriction · Exercise
Primary: Body Composition at the End of Each Study Phase — 78.3; 78.0; 73.3; 75.8 kilograms
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=121 Fat Mediated Modulation of Reproductive and Endocrine Function in Young Athletes
Exercise-related Amenorrhea
Primary: Change in Lumbar Bone Mineral Density — 0.025; 0.008; 0.012 g/cm^2 — p=0.039
N/A N=201 Study of Nutrition and Activity in Kids
Obesity, Adolescent · Adolescent Behavior
Primary: zBMI Change — 0.433; 0.55; 0.376; 0.61 z-score
N/A N=481 Efficacy of the Female Athlete Body Project (FAB)
Eating Disorders · Female Athlete Triad
Primary: Eating Disorder Examination Questionnaire (EDE-Q) — .98; 1.24; .54; .84 units on a scale
N/A N=20 Essential Amino Acids and Protein Kinetics During Caloric Deprivation
Muscle Protein Synthesis · Whole-body Protein Balance
Primary: Postprandial, Resting Muscle Protein Synthesis Rates — 0.055; 0.061 percent per hour
Phase 3 N=77 Bone Loss in Women With Anorexia Nervosa
Anorexia Nervosa
Primary: Bone Mineral Density — 3.2; -0.6 percent change — p=<0.0001
Phase 3 N=80 Adrenal and Gonadal Hormone Replacement in Anorexia Nervosa
Anorexia Nervosa
Primary: Areal Bone Density by DXA — 0.88; 0.89 g/cm2
N/A N=116 Study of Refeeding to Optimize iNpatient Gains
Anorexia Nervosa
Primary: Number of Participants With Clinical Remission at Different Time Points of Assessment — 12; 8; 10; 13 Participants — p=0.42
N/A N=198 The Comparison of Energy in Take and Body Weight EXERCISE
Exercise · Energy · Body Weight
Primary: A Comparison of the Effects of Energy Balance With Three Groups. [Energy Intake, Adjusted DLW] — 123.6; 90.7; -2.3 kcal/day
Phase 2 N=11 Transdermal Estrogen in Older Premenopausal Women With Anorexia Nervosa
Anorexia Nervosa · Osteoporosis
Primary: Percent Change in Bone Mineral Density (BMD) of Lumbar Spine by Dual Energy X-ray Absorptiometry (DXA) — 2.0 percent change
N/A N=87 Assessment of Energy Balance
Caloric Intake and Energy Metabolism
Primary: ENERGY BALANCE EQUATION, PHASE I, ONE SUB-STUDY — 2360; 2208; -152 kCal
Phase 4 N=41 A Double-blind, Placebo Controlled Trial of Risperidone for the Treatment of Anorexia Nervosa
Anorexia Nervosa
Primary: Change in Eating Disorder Inventory-2 Drive for Thinness Subscale (DT) — 1.36; 3.93 units on a scale
N/A N=59 Reward Re-Training: A New Treatment to Address Reward Imbalance During the COVID-19 Pandemic
Bulimia Nervosa · Bulimia; Atypical · Binge Eating
Primary: Binge Eating Frequency Assessed by the Eating Disorder Examination — 25.10; 25.27; 9.19; 13.07 Binge eating episodes
Phase 3 N=75 Effects of Anorexia Nervosa on Peak Bone Mass
Anorexia Nervosa
Primary: Change in Bone Density Over a 12-month Period — 0.045; 0.280 score on a scale — p=.109
N/A N=17 TRE With Physical Activity for Weight Management
Pre Diabetes · Overweight and Obesity
Primary: Body Weight Changes Between Week 1 to Week 10 — -2.1; -4.2; -1.3; .1 Percent body weight loss
N/A N=82 IGF-1 and Bone Loss in Women With Anorexia Nervosa
Anorexia Nervosa · Osteopenia · Osteoporosis
Primary: Postero-anterior Spine Bone Mineral Density by DXA — 0.891; 0.887; 0.874 g/cm2 — p=0.03
N/A N=88 Exercise Intolerance in Elderly Patients With HFpEF(Heart Failure With Preserved Ejection Fraction)
Heart Failure, Diastolic · Obesity
Primary: Peak Exercise Oxygen Consumption (VO2) — 1609; 1653 ml/min — p=0.21
N/A N=2,506 Modeling the Epidemiologic Transition Study
Obesity · Diabetes
Primary: Change in Body Weight — 0.69; 0.76; 0.20; 0.81 kilograms (kg)
N/A N=32 Impaired Regulation of Energy Balance in Elderly People (Balance Study)
Anorexia of Ageing
Primary: Energy Intake Compensation — 1; 1 MJ/day
N/A N=159 Development of Eating Disorders Symptoms Among Children
Eating Disorders Symptoms
Primary: Number of Participants With >20 on the 26 Children Eating Attitudes Test — 26; 4 Participants
Phase 2 N=28 Effects of rhIGF-1 on Bone Metabolism in Adolescent Girls With Anorexia Nervosa
Disorder of Bone Density and Structure, Unspecified
Primary: Change in Spine Bone Density (g/cm^2) — -0.00558 gm/cm^2 — p=0.40
N/A N=180 Efficacy Trial of a Dissonance Based Eating Disorder Program
Eating Disorder
Primary: Rosenberg Self-Esteem Scale (RSE). — 22.71; 22.50; 22.62 units on a scale
Phase 3 N=110 Effects of Anorexia Nervosa on Bone Mass in Adolescents
Anorexia Nervosa
Primary: Percent Change in Spine Bone Density Over the Study Duration (18 Months) — 2.6; 0.3 Percent change — p=<0.05
Phase 3 N=30 Effects of Denosumab on Bone Mineral Density in Women With Anorexia Nervosa: A Pilot Study
Bone Density · Bone Loss · Anorexia Nervosa
Primary: Postero-anterior (PA) Lumbar Spine Bone Mineral Density by Dual-energy X-ray Absorptiometry (DXA) — 0.90; 0.87 g/cm^2 — p=0.009
Phase 3 N=172 Perimenopausal Estrogen Replacement Therapy Study
Perimenopause · Menopause · Depression
Primary: Change in Depressive Symptoms as Indicated by The Center for Epidemiologic Studies Depression Scale (CES-D) — 1.04; -1.02 units on a scale
N/A N=58 Intensive Aerobic and Resistance Exercise Program (IAREP)
Type 2 Diabetes Mellitus · Cognitive Impairment · Non-insulin-dependent Diabetes Mellitus
Primary: Change in Cognitive Function Based on Risk Stratification Score (RSS) — -0.2; -0.1; -0.8; 0.0 score on a scale
N/A N=47 Females, Aging, Metabolism, and Exercise
Obesity
Primary: Change in Physical Activity Energy Expenditure (PAEE) — 74.5; -10.2; 61.0 kcal/day
Phase 2 N=90 Hormonal Factors in the Treatment of Anorexia Nervosa
Anorexia Nervosa · Eating Disorder · Anxiety
Primary: Change From Baseline in Weight — 0.1; 1.5 kilograms
N/A N=28 Relative Sarcopenia and Cardiometabolic Risk in Young Adults With Obesity
Overweight and Obesity · Insulin Resistance
Primary: Percent Change in Serum Myostatin Levels From Pre- to 3 Hours Post-exercise — -6.9; 8.5 % change in serum myostatin — p=0.303
Phase 4 N=8 Impact of Erythropoietin on Hematological Adaptations and Physical Performance
Exercise-Induced Anemia · Physical Performance
Primary: Concentration of Hemoglobin — 1.46 g/dL