N/A N=80 Saphenous Nerve Block for Foot and Ankle Surgery
Saphenous Nerve Block
Primary: Block Success — 18; 22 participants — p=0.25
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N/A N=60 Saphenous Nerve Block vs. Femoral Nerve Block for Total Knee Arthroplasty
Difference Between Femoral Nerve Block and Saphenous Block
Primary: Visual Analogue Scale Pain Score — 2.81; 2.47 units on a scale
N/A N=94 Saphenous Nerve Block Versus Femoral Nerve Block for Total Knee Arthroplasty
Total Knee Arthroplasty
Primary: Quadriceps Muscle Strength — 7.3; 2.2 kilogram-force
N/A N=32 Evaluation of Continuous Saphenous Nerve Block to Supplement a Continuous Sciatic Nerve Block After Ankle Surgery
Orthopedic Surgery of Lower Extremity
Primary: Verbal Pain Scores — 4.2; 5.4 units on a scale
Phase 4 N=68 Infrapatellar Nerve Block for Post-operative Knee Arthroscopy Pain Control
Internal Derangement of Knee
Primary: Post op Pain Score — 5.5; 3.9 units on a scale
Phase 4 N=30 Peripheral Nerve Blocks for Above-the-knee Amputations
Peripheral Vascular Diseases · Hyperglycaemia (Diabetic) · Hypertension
Primary: Peripheral Nerve Block Success as a Primary Anesthetic — 1 Participants
N/A N=49 Pudendal Nerve Block for Hemorrhoidectomy
Hemorrhoids · Postoperative Pain
Primary: Postoperative Pain on the Visual Analogue Scale (VAS) — 1.4; 3.1 units on a scale
N/A N=70 Comparing Through-the-Needle With Suture-Method Catheter Designs for Popliteal Nerve Blocks
Regional Anesthesia · Sciatic Nerve Block
Primary: Average Pain — 2.7; 3.4 score on a scale
Phase 1 N=90 Prolonged Popliteal Fossa Nerve Blockade (Prolonged Pop)
Postoperative Pain
Primary: Numeric Rating Scale (NRS) Pain Score With Movement — 1.9; 1; 1.3 units on a scale
N/A N=50 Effect of a Sciatic Block (SNB) Combined With a Continuous Femoral Block (CFNB) on Pain Scores After Knee Arthroplasty
Postoperative Pain
Primary: Visual Analogue Scores (VAS) - Pain Scores Measured in mm (0-100) — 59.4; 30.2 units on a scale — p=0.001
N/A N=250 Ultrasound Guided Distal Sciatic Nerve Block - a Comparison With Nerve Stimulator Technique
Other Surgical Procedures
Primary: Success Rate Without Supplementation — 112; 73 participants — p=< 0.05
N/A N=40 Femoral/Sciatic Block for Knee Surgery
Knee Injuries
Primary: Analgesic Efficacy — 0; 0.1; 0.6; 3.0 units on a scale — p=<0.05
Phase 3 N=42 Comparing Ways to Freeze the Nerve That Provides Thigh Sensation
Meralgia Paresthetica
Primary: Anesthesia Related Time — 554; 480 seconds — p=0.05
Phase 3 N=103 Ultrasound Guided Supraclavicular Nerve Block
Local Anesthetic
Primary: Duration of Analgesia. — 7.5; 10 minute — p=0.14
Phase 4 N=60 Efficacy of Popliteal Nerve Blocks With and Without Dexamethasone on the Duration of Analgesia for Foot & Ankle Surgery
Foot and Ankle Procedures
Primary: Postoperative Pain — 0.21; 0.05 Scores on a scale
Phase 4 N=150 Adductor Canal Block for Medial Compartment Knee Arthroplasty
Postoperative Analgesia · Medial Unicompartmental Knee Arthroplasty
Primary: Verbal Pain Scores at 6 Hours Post Nerve Blockade. — 1; 1.1; 1.6; 1.5 score on a scale
Phase 4 N=80 Analgesic Benefits of Perineural Versus Intravenous Dexamethasone in Patients Receiving Sciatic Nerve Block
Fracture of Ankle
Primary: Quality of Recovery — 181; 184; 181 units on a scale
Phase 4 N=52 Ultrasound Guided Distal Peripheral Nerve Blocks and Postoperative Pain.
Postoperative Pain
Primary: Proportion of Patients Who Experienced Moderate to Severe Pain During First and Second Postoperative Day — 8.3; 80.8; 4.2; 42.3 percentage of patients
Phase 4 N=40 Genicular Nerve Block for Total Knee Arthroplasty
Post-operative Pain
Primary: Opioid Consumption at 24 Hours Post-op — 22.9; 58.1 milligrams of oral morphine equivalents
Phase 2 N=58 Safety, Efficacy, and Pharmacokinetics of SKY0402 Administered as a Nerve Block in Subjects Undergoing Bunionectomy
Postoperative Pain
Primary: Time to First Use of Supplemental Pain Medication Postoperatively for Surgical Pain — 9.4; 1.9; 1.2; 2.4 hours
Phase 4 N=24 Continuous Adductor Canal Nerve Blocks: Relative Effects of a Basal Infusion v. Hourly Bolus Doses
Healthy Human Volunteers
Primary: Tolerance to Cutaneous Electrical Current — 26.6; 27.1 mA
N/A N=72 Pudendal Nerve Block in Vaginal Surgery
Nerve Block · Pain, Postoperative · Pelvic Floor Disorders
Primary: Visual Analog Scores at 7am After Surgery — 29.2; 42.6 score on a scale
Phase 4 N=165 Peripheral Nerve Blocks vs Periarticular Local Anesthetic Injection for Total Knee Arthroplasty (TKA)
Total Knee Arthroplasty
Primary: Maximum Pain Post-Operative Day (POD) 1 (Morning) — 3; 4; 4.5 units on a scale — p=0.144
Phase 4 N=20 MIDCAB (Mid-Calf Block) for Foot Surgery
Ankle Surgery · Foot Surgery
Primary: Block Duration — 18.2 hours
N/A N=80 Posterior Capsular Injection With Femoral Nerve Block for Total Knee Arthroplasty
Posterior Knee Infiltration
Primary: Pain Intensity — 3.5; 3.2; 2.1; 1.5 pain score
Phase 4 N=50 Septorhinoplasty Post-operative Pain Control With SPG Nerve Block
Deviated Nasal Septum
Primary: Post Operative Pain Scores — 3.9; 3.8; 2.7; 2.9 pain score on a scale of 0-10
Phase 4 N=85 Perineural Steroids for Peripheral Nerve Blocks
Osteoarthritis, Knee
Primary: Duration of Sensory Nerve Block — 37.00; 31.75; 29.67 hours
Phase 4 N=132 Adductor Canal Block Versus Femoral Block on Pain and Quadriceps Strength
Anterior Cruciate Ligament Tear · Knee Meniscus Tear
Primary: Change in Quadriceps Strength Related to the Nerve Block — -0.42; -0.55; -3.19; -0.77 Newtons
Phase 4 N=100 Serratus Plane Versus Paravertebral Nerve Blocks for Breast Surgery
Breast Surgery
Primary: Mean/Median Numeric Rating Scale Pain Score Within the Recovery Room — 4; 0 score on a scale — p=0.001
Phase 4 N=142 The Use of Bupivacaine and Ropivacaine for Sciatic Nerve Block
The Duration of Motor Block May Vary Between 12-36 Hrs
Primary: Duration of Motor and Sensory Block of the Sciatic With 0.5% Bupivacaine and Ropivacaine After Ultrasound-guided Nerve-stimulator-Assisted Needle Positioning Beneath the…