N/A N=63 Varenicline-Aided Cigarette Reduction in Smokers Not Ready to Quit
Tobacco Use Disorder
Primary: Cigarette Reduction — 10; 11 participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=1,493 A Study To Evaluate The Efficacy And Safety Of Varenicline Compared To Placebo For Smoking Cessation Through Reduction
Smoking Cessation
Primary: Percentage of Participants With Carbon Monoxide (CO) Confirmed 10-Week Continuous Abstinence (CA) From Smoking — 32.1; 6.9 percentage of participants — p=<0.0001
Phase 3 N=81 Nicotine Lozenge or Tobacco-Free Snuff for Smokeless Tobacco Reduction
Tobacco Dependence
Primary: Tobacco Abstinence at 12 Weeks — 8; 5 participants
N/A N=31 Impact of Exclusive Use of Low Nicotine Cigarettes on Compensatory Smoking
Smoking
Primary: Breath Sample (Expired Carbon Monoxide) — 18.77; 31.07; 25.38; 30.49 parts per million — p=0.92
N/A N=136 Reduced Nicotine Content Cigarettes and Tobacco Switching Behaviors
Tobacco Addiction · Dual Tobacco Use
Primary: Number of Days Using Alternative Products — 14; 26; 20 Number of days
Phase 2 N=162 Facilitating Smoking Cessation With Reduced Nicotine Cigarettes
Smoking Cessation
Primary: Study 1 - Rate of Participant Completion of Pilot — 4; 5 Participants
N/A N=188 Reduced Nicotine Cigarettes in Smokers With Mood and Anxiety Disorders
Tobacco Dependence
Primary: Plasma Cotinine Concentration — 82.8; 259.0 ng/mL — p=<0.0001
Phase 2 N=746 Gradual vs. Abrupt Cessation Treatment for Smoking
Smoking Cessation
Primary: Number of Participants With Prolonged Abstinence Through 6 Months Verified by Carbon Monoxide Measurement — 12; 20; 7 participants — p=0.30
Phase 2 N=332 Comparison Across Treatment Conditions to Reduce Smokeless Tobacco Use
Tobacco Use Disorder
Primary: Percent Abstinent From Tobacco at Week 12 (7 Day Point Prevalence) — 31; 17 percentage of randomized — p=0.04
Phase 3 N=74 Switching to Very Low Nicotine Content Cigarettes vs Reducing Cigarettes Per Day
Tobacco Use Disorder
Primary: Feasibility as Indicated by Self-reported Adherence to Study Cigarettes. — 7.1; 7.3; 10.4; 13.3 Percent non-study cigarettes per day
N/A N=245 Reduced Nicotine Content Cigarettes in Smokers of Lower Socioeconomic Status
Tobacco Dependence
Primary: Number of Participants Who Dropped Out of Study as a Measure of Adherence — 52; 19 Participants — p=<0.0001
Phase 4 N=517 Identifying Treatments to Motivate Smokers to Quit
Smoking · Smoking Cessation · Motivation
Primary: Percent Change in Cigarettes Smoked Per Day (CPD) — 38.7; 38.9; 37.4; 40.2 Percent Change in cigarettes per day — p=.98
N/A N=7 E-cigarettes to Promote Smoking Reduction Among Individuals With Schizophrenia
Tobacco Smoking
Primary: Change in Smoking as Assessed by Breath Carbon Monoxide Levels — -18; -4.3 parts per million (ppm)
Phase 3 N=216 Maintaining Nonsmoking
Nicotine Dependence
Primary: Number of Participants With Reported 7-day Point Prevalence Abstinence at Week 12 — 22; 20; 29; 20 Participants
N/A N=34 Youth Smoking Cessation: Therapy +/- "The Patch"
Smoking
Primary: Acceptance of Nicotine Replacement Therapy — 26 participants
Early Phase 1 N=21 Reduced Nicotine Cigarette Purchasing Decisions
Tobacco Use Disorder
Primary: Demand Intensity — 6.48; 8.10; 7.81; 6.48 cigarettes
N/A N=100 Electronic Cigarettes (E-cigarettes) as a Harm Reduction Strategy
Tobacco Use Disorder · Smoking
Primary: Changes in the Number of Cigarettes Per Day (CPD) — 8.2; 7.3 cigarettes per day (CPD)
N/A N=74 Smoking Reduction In Gravid Substance Use Disorders
Tobacco Smoking in Mother Complicating Pregnancy · Tobacco Use Disorder · Tobacco Smoking
Primary: Prevalence of Smoking ≥ 10 Cigarettes/Day in Each Group at Final Measurement by Exhaled Carbon Monoxide Level — 22; 16 participants — p=0.06
N/A N=213 Very Low Nicotine Content Cigarettes and E-Cigarettes in Promoting Smoking Cessation in Daily and Intermittent Cigarette Smokers
Cigarette Smoking-Related Carcinoma · Tobacco-Related Carcinoma
Primary: Usual Brand Cigarettes Per Day — 15.803; 2.1563; 1.8353; 1.4931 Cigarettes per Day
N/A N=30 Quit or Switch: E-cigarette Study
Tobacco Use
Primary: Percentage of Participants Who Report Daily Use of E-cigarettes or NRT and no Cigarette Use
N/A N=1,901 Messages About Reduced Nicotine in Combusted Tobacco Products
Health Communication · Smoking · Smoking, Tobacco
Primary: Perceived Health Risk of VLNCs (Absolute) — 4.09; 3.81; 4.03; 3.87 score on a scale
N/A N=67 Development of a Mindfulness-Based Treatment for the Reduction of Alcohol Use and Smoking Cessation
Tobacco Use · Alcohol Use, Unspecified
Primary: Aim 2: Number of Participants Scoring >3 — 18; 16 participants
Phase 2 N=49 Impact of Nicotine Reduction on Adolescent Cigarette Use, Alternative Tobacco Use, and Harm From Tobacco
Nicotine Dependence, Cigarettes, Uncomplicated
Primary: Average Cigarettes Smoked Per Day — 4.3; 8.0 average cigarettes per day — p=.111
N/A N=40 Smoking Cessation and Reduction With an Electronic Nicotine Delivery Device (ENDD)
Nicotine Dependence · Smoking Cessation
Primary: Sustained 50% Reduction in the Number of Cig/Day at Week-24 From Baseline (Reducers) — 13 number of participants
N/A N=84 Puff Biofeedback to Reduce Smoking Reinforcement
Cigarette Smoking
Primary: Cigarette Purchase Task- Omax — 18.84; 18.80 cigarettes — p=.71
N/A N=1,132 Correcting Public Misperceptions About Very Low Nicotine Content Cigarettes
Tobacco Use, Cigarette Use
Primary: Very Low Nicotine Content (VLNC) Misperception — 3.12; 3.04; 3.04; 3.36 score on a scale
N/A N=190 Reducing Tobacco Use Disparities Among Low-Income Adults
Cigarette Smoking · Nicotine Dependence
Primary: Quitline Treatment Engagement — 25; 0 Participants
Phase 4 N=93 Varenicline for Light Smokers
Smoking
Primary: Point Prevalence Smoking Outcome at 12 Weeks (End of Treatment) — 24; 7 participants — p=<0.001
N/A N=326 Low Nicotine Content Cigarettes in Vulnerable Populations: Women of Reproductive Age
Tobacco Use Disorder
Primary: Number of Cigarettes Smoked Per Day — 22.54; 14.32; 11.76; 7.63 cigarettes per day
N/A N=60 Predictors and Consequences of Combustible Cigarette Smokers' Switch to Standardized Research E-Cigarettes
Tobacco Use
Primary: Combustible Cigarette Use — 3.79; 3.64 Number of cigarettes smoked per day