N/A N=82 Patient Response to Spinal Manipulation
Low Back Pain
Primary: Patient-Centered Outcome Measurement Mean Change After 6 Weeks (VAS, RMDQ) — 20.1; 4.8 units on a scale (see description above)
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=221 Effect of Spinal Manipulation on Sensorimotor Functions in Back Pain Patients
Low Back Pain
Primary: Postural Sway — -.13; -0.26; -0.18; -0.06 mm
Phase 2 N=241 Optimization of Spinal Manipulative Therapy Protocols
Low Back Pain
Primary: Spinal Stiffness — 6.20; 6.28; 6.10; 6.07 N/mm — p=0.025
N/A N=192 Predicting Patients' Response to Spinal Manipulation
Low Back Pain
Primary: Roland Morris Low Back Pain Disability Questionnaire (RMDQ) — 4.0; 3.8; 1.0 units on a scale
N/A N=107 Chiropractic Manipulation and Medical Care for Low Back Pain
Low Back Pain
Primary: Oswestry Low Back Pain Disability Index — -16.0; -8.9; -9.5 units on a scale — p=0.009
N/A N=195 Spinal Manipulation Services vs. Prescription Drug Therapy for Long-term Care
Low Back Pain
Primary: Self-reported QOL - Physical Health — 41.7; 28.8; 31.8; 32.9 units on a scale
Phase 3 N=1,000 Spinal Manipulation and Patient Self-Management for Preventing Acute to Chronic Back Pain
Acute Pain · Low Back Pain, Mechanical
Primary: Pain Intensity — 2.8; 3.0; 2.8; 3.0 score on a scale — p=0.16
N/A N=25 The Role of the Rate of Force Application in Responses to Spinal Manipulation Therapy
Spinal Manipulation
Primary: Left T6 Normalized Root Mean Square (RMS) Value — 3.72 ratio
Phase 2 N=110 The Mechanisms of Manual Therapy in the Treatment of Low Back Pain
Low Back Pain
Primary: Believability of Placebo — 67; 37; 78 percentage of participants — p=<0.01
N/A N=350 The McKenzie Method Versus Manipulation for Patients With Chronic Low Back Pain
Low Back Pain
Primary: Disability — 6.7; 5.2 Units on a scale — p=>0.05
N/A N=28 The Effect of Manipulation of the Cervical Spine on Pain Biomarkers
Neck Pain, Posterior
Primary: Plasma Concentration of Oxytocin — 154.5; 158.8 ug/ml
N/A N=131 Spinal Pain and Autonomic Responses to Chiropractic Care
Neck Pain
Primary: Change in Heart Rate Variability — 843; 887 ms
N/A N=6 Patient Response to Spinal Manipulation - Pilot Study
Low Back Pain
Primary: Feasibility of Conducting a Full-scale Randomized Control Trial to Evaluate Patient Response to Spinal Manipulation: Number of Participants Who Were Recruited…
N/A N=20 Visceral Manipulation in Patients With Chronic Low Back Pain
Chronic Low Back Pain
Primary: Low Back Pain After 6 Weeks of Intervention — 6.50; 6.00; 1.50; 3.50 units on a scale
N/A N=40 Investigating the Effects of a Spinal Mobilisation Intervention in People With Lower Back Pain
Lower Back Pain
Primary: Intervention Erector Spinae Stiffness Change — -10.959 Newton metres (Nm) — p=<0.05
N/A N=20 MS Spinal Mobilisation Study
Multiple Sclerosis
Primary: Participant Muscle Stiffness Measure — 350.83; 240.07 Newton-metres
N/A N=220 Comparative Effectiveness of Acute Low Back Pain Management
Low Back Pain
Primary: Oswestry Disability Index — 9.8; 6.6 units on a scale
Phase 2 N=10 Tailored Computerized Mobilization of the Cervical Spine Utilizing the Occiflex Device for the Treatment of Chronic Neck Pain
Neck Pain
Primary: Occiflex Device Safety — 26 Number of adverse effects
N/A N=20 Vertebral Artery and Cerebral Hemodynamics After Various Head Positions & Manipulation in Patients With Neck Pain
Vertebral Artery Dissection · Cerebrovascular Accident · Stroke
Primary: Changes in Blood Flow Through the Vertebral Artery and Posterior Cerebral and Cerebellar Circulation — 15.5; 15.1; 14.7 cm/s
N/A N=51 Chiropractic for Hypertension in Patients
Hypertension
Primary: Unadjusted and Adjusted Changes From Baseline in Systolic and Diastolic Blood Pressure at Weeks 1, 3, 6 — -1.2; -5.3; 0.8; -1.7 mmHg
N/A N=50 The Effect of TheraBand® Kinesiology Tape on Post-manipulation Pain and Range of Motion
Acute Non-complicated Postural Neck Pain
Primary: Change in Cervical Range of Motion — 37.9; 36.9; 39.5; 37.5 degrees
Phase 3 N=455 Osteopathic Health Outcomes in Chronic Low Back Pain (OSTEOPATHIC) Trial
Low Back Pain
Primary: Change in Visual Analogue Scale Score for Pain Over 12 Weeks (OMT vs Sham OMT) — 40; 20 participants — p=0.007
N/A N=51 Spinery® A Novel Radio-Frequency Tumor Ablation Device for Spine Metastatic Tumors
Vertebral Metastasis
Primary: Change From Baseline in Worst Pain and Quality of Life Scores at 3 Months Using the Brief Pain Inventory (BPI) and EQ-5D-5L Questionnaires — 3.4; 65.2 points on a…
N/A N=48 Manual Cervical Distraction: Measuring Chiropractic Delivery for Neck Pain Clinical Trial
Neck Pain · Pain in Arm, Unspecified
Primary: Range of Traction Forces — 13.82; 38.3; 65.08; 17.19 Newtons (N)
N/A N=98 Preventive Care of Chronic Cervical Pain and Disabilities
Neck Pain
Primary: Neck Pain — 3.8; 3.3; 3.4 cm
N/A N=750 Assessment of Chiropractic Treatment for Low Back Pain and Smoking Cessation in Military Active Duty Personnel.
Lower Back Pain
Primary: Numerical Rating Scale (NRS) for Prior Week — 4.27; 4.36; 4.73; 4.45 units on a scale
N/A N=64 Talocrural Joint Manipulation in Stroke
Stroke
Primary: Overall Stability Index Measurement — 17.5; 9 units on a scale
N/A N=30 Complementary Therapies in Spinal Fusion Patients
Idiopathic Scoliosis
Primary: Postoperative Pain (Total Opioid Use) — 0.041; 0.048; 0.054; 0.038 mg/kg/hr
N/A N=21 Myofascial and Articular Treatment of Adolescent Idiopathic Scoliosis
Scoliosis Idiopathic Adolescent Treatment
Primary: Cobb Angle — 18.9; 23.8 degrees
N/A N=259 Study Comparing 3 Different Treatments for Arthritis of the Lower Back (Lumbar Spinal Stenosis)
Lumbar Spinal Stenosis
Primary: Swiss Spinal Stenosis (SSS) Questionnaire Score — -2.0; -1.7; -4.1 units on a scale — p=0.73