Phase 2 N=13 Energy Metabolism in Thyroidectomized Patients
Thyroid Goiter · Hypothyroidism · Thyroid Cancer
Primary: Short Term Change in Weight — 1.7; -0.76 Kilogram
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=31 Thyroid Hormones Homeostasis and Energy Metabolism Changes During Stimulation of Endogenously Secreted Bile Acids (BAs)
Healthy Volunteers
Primary: Energy Expenditure — 1.37; 1.40; 1.28; 1.27 kcal/min — p=0.0001
N/A N=10 Circadian Brown Adipose Tissue Metabolism
Healthy
Primary: Change in Maximum Standardized Update Value (SUVmax) in Brown Adipose Tissue FDG Uptake in the Neck or Upper Chest on Evening and Imaging Compared to Morning Imaging
N/A N=26 Fatty Acid Oxidation Disorders & Body Weight Regulation Grant
Trifunctional Protein Deficiency
Primary: An Outcome of This Study is the Difference in Percent Body Fat (%BF) Between Subjects With a Long-chain Fatty Acid Oxidation Disorder and Normal Controls. — 31.8; 27.2…
N/A N=21 Effects of Low Fat Versus Low Carbohydrate Diets on Energy Metabolism
Healthy · Healthy Volunteers
Primary: Ad Libitum Energy Intake — 2752; 2063 kcal per day
N/A N=47 Females, Aging, Metabolism, and Exercise
Obesity
Primary: Change in Physical Activity Energy Expenditure (PAEE) — 74.5; -10.2; 61.0 kcal/day
Phase 2 N=47 Study of Human Non-Shivering Thermogenesis and Basal Metabolic Rate
Healthy Volunteers
Primary: Resting Energy Expenditure at Low Temperature — 1.277; 1.134; 1.300; 1.271 kcal/min
N/A N=8 Whole Body Protein Metabolism of a Whey/EAA Supplement Using Continuous Oral Stable Isotopes
Healthy
Primary: Whole-body Protein Net Balance — 6.2; 11.8 grams
N/A N=87 Assessment of Energy Balance
Caloric Intake and Energy Metabolism
Primary: ENERGY BALANCE EQUATION, PHASE I, ONE SUB-STUDY — 2360; 2208; -152 kCal
N/A N=54 Food Intake Response to Short-Term Modifications of Metabolism in Humans
Healthy Volunteers
Primary: 24-hour Energy Expenditure (kcal) — 2256; 2166; 2563; 2487 kcal
N/A N=20 Effect of Vestibular Stimulation on Fat Consumption and Energy Expenditure as Assessed Using Indirect Calorimetry
Obesity · Metabolic Syndrome
Primary: Change in Fat Consumption (During VeNS) — 50.23; 54.44 % of fat as metabolic substrate
N/A N=32 The Influence of Glycemic Control and Obesity on Energy Balance and Metabolic Flexibility in Type 1 Diabetes
Type 1 Diabetes
Primary: Energy Expenditure — 1978.3; 1969.8; 2414.8; 1497.7 Kilocalories — p=0.24
N/A N=20 Hepatic Mitochondrial Function in Youth
Hepatic Steatosis · Bariatric Surgery Candidate · Adolescent Obesity
Primary: Change in Percentage of Liver Fat Per MRI — -13.93 percentage of liver fat
N/A N=32 Impaired Regulation of Energy Balance in Elderly People (Balance Study)
Anorexia of Ageing
Primary: Energy Intake Compensation — 1; 1 MJ/day
N/A N=89 Long Duration Activity and Metabolic Control After Spinal Cord Injury
Spinal Cord Injuries
Primary: Acute Gene Regulation: NR4A3 mRNA Expression Pre and Post-Stimulation — 3.235; 2.711; 6.286; 5.772 arbitrary units — p=<0.001
N/A N=198 The Comparison of Energy in Take and Body Weight EXERCISE
Exercise · Energy · Body Weight
Primary: A Comparison of the Effects of Energy Balance With Three Groups. [Energy Intake, Adjusted DLW] — 123.6; 90.7; -2.3 kcal/day
N/A N=39 Effect of Caloric Restriction on Fat Oxidation in Obese Men and Women (Magellan II)
Obesity · Overweight · Metabolic Diseases
Primary: Change From Baseline Amount of Fat Oxidation at 14 Days — 0.91; 0.94 Fold change of RQ ratio
N/A N=98 Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation
Mild Cognitive Impairment · Metabolic Syndrome
Primary: MoCA (Montreal Cognitive Assessment) — 28.38; 20.22 score on a scale — p=<0.0001
N/A N=33 Training Effects on Skeletal Muscle Fatty Acid Metabolism
Healthy Volunteers
Primary: Insulin Sensitivity as Measured by Hyperinsulinemic Euglycemic Clamp at a Single Time Point (6 Hrs) After Intralipid or Glycerol Infusion — 8; 12; 6; 11 M value — p=<0.05
N/A N=137 Beige Fat, Energy, and the Natriuretic Peptide System
Obesity
Primary: Adipose Tissue Gene Expression of UCP1 (Uncoupling Protein 1)- Differences by Obesity Status — 7.79; 24.33 fold change — p=<0.01
Phase 3 N=42 Energy Balance & Weight Loss in Craniopharyngioma-related or Other Hypothalamic Tumors in Hypothalamic Obesity
Hypothalamic Obesity
Primary: Percent Change of Body Mass Index (BMI) as Calculated by the Formula: Body Weight in kg Divided by Height in Meters². — 1.7; 3.5 percent change from baseline — p=0.40
N/A N=10 Novel Approach to Assess Metabolic Flexibility in a Respiratory Chamber
Diabetes Mellitus, Type 2
Primary: Overnight Respiratory Exchange Ratio — 0.832; 0.887 ratio
N/A N=32 Metabolomics of Insomnia-Related Hyperarousal
Primary Insomnia
Primary: Number of Metabolites Elevated Relative to the Other Group. — 13; 9 Number of metabolites elevated
N/A N=37 Forearm Immobilization, Metabolic Health, and Muscle Loss
Healthy
Primary: Percent Change in Forearm Glucose Uptake — -73; 127; -95 Percent change in clamp FGU with immob
N/A N=5 Sympathetic Activation in Obesity
Obesity · Healthy
Primary: Distribution Volume Ratio (DVR) of [11C]MRB PET Imaging of Peripheral Sympathetic Nervous System — 0.13; -0.025; 0.095; -0.03 DVR
N/A N=69 Brown Adipose Tissue Activity in Pre- and Postmenopausal Women
Menopause · Obesity
Primary: Brown Adipose Tissue Volume — 53.1; 20.6 mL
N/A N=60 Dietary Carbohydrate Manipulation and Energy Balance: RCT
Physical Activity · Diet Modification
Primary: Physical Activity Energy Expenditure (kJ/Day or kcal/Day) — 1229; 1096; 1275; 1142 kcal/d
Phase 3 N=32 Behavioral Mechanism of Energy Compensation With Exercise
Obesity · Weight Loss · Eating Behavior
Primary: Attentional Bias — 48.85 percentage of time fixated on food cues
N/A N=2,506 Modeling the Epidemiologic Transition Study
Obesity · Diabetes
Primary: Change in Body Weight — 0.69; 0.76; 0.20; 0.81 kilograms (kg)
Phase 2 N=10 Measurement of Glucose/Glycogen Metabolism in Humans Using Magnetic Resonance at 4 or 7 Tesla
Type 1 Diabetes
Primary: Brain Glycogen Turnover Rate — 0.31; 0.28 mg/kg/min