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Home › Medications › amiodarone

amiodarone

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of amiodarone

10 trials tracked of amiodarone: 8 in phase 3 or 4 and 2 with published results. The most-cited published study has 460 citations.

10Trials tracked
8Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 3 Phase 3 5 Phase 2 1 Other / NA 1
  1. Phase 3 Amiodarone, Lidocaine or Neither for Out-Of-Hospital Cardiac Arrest Due to Ventricular Fibrillation or Tachycardia Completed · 460 cited
  2. Phase 3 Rate Control Versus Rhythm Control For Postoperative Atrial Fibrillation Completed · 398 cited
  3. Phase 4 Atrial Fibrillation Without Hemodynamic Instability in the Intensive Care Unit Completed
  4. Phase 4 Prevention of Atrial Fibrillation Following Esophagectomy Completed
  5. Phase 4 Prevention of Atrial Fibrillation Following Noncardiac Thoracic Surgery Completed
  6. Phase 3 Prophylaxis to Reduce Postoperative Atrial Fibrillation in Cardiac Surgery Completed
Show 4 more trials
  1. Phase 3 n-3 Polyunsaturated Fatty Acids (PUFAs) in the Prevention of Atrial Fibrillation Completed
  2. Phase 3 Efficacy & Safety of Dronedarone Versus Amiodarone for the Maintenance of Sinus Rhythm in Patients With Atrial Fibrillation Completed
  3. Phase 2 Evaluate the Pharmacokinetics and Safety of MK-4448 in Participants With Nonvalvular Atrial Fibrillation or Atrial Flutter Completed
  4. N/A Amiodarone for the Prevention of Reperfusion Ventricular Fibrillation Completed

Showing the 10 most-cited and recently-updated of 10 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Antazoline May Beat Propafenone and Amiodarone for AF Conversion
Cardiology Meta-analysis
Antazoline May Beat Propafenone and Amiodarone for AF Conversion Antazoline shows better results for atrial fibrillation heart rhythms
A meta-analysis suggests antazoline is more effective than propafenone or amiodarone for converting atrial fibrillation to sinus rhythm, wit…
A new review suggests antazoline may be more effective than common medications at restoring normal heart rhythms for patients with atrial fi…
NEJM Jul 26, 2026
Pulsed field ablation beats antiarrhythmic drugs as first-line persistent AF therapy
Cardiology RCT
Pulsed field ablation beats antiarrhythmic drugs as first-line persistent AF therapy Pulsed field ablation shows higher success than drugs for heart rhythm
In a randomized trial of 207 patients with previously untreated persistent atrial fibrillation, pulsed field ablation (PFA) achieved 56% tre…
A new trial shows pulsed field ablation provides a much higher success rate than standard drugs for patients with persistent atrial fibrilla…
Jun 25, 2026
Apixaban Plasma Levels Elevated in Medicare Patients Taking CYP3A4 and P-gp Inhibitors
Drug Pipeline Cohort
Apixaban Plasma Levels Elevated in Medicare Patients Taking CYP3A4 and P-gp Inhibitors Higher Drug Levels Mean More Bleeding Risk
This pilot cohort study evaluated 35 Medicare patients with atrial fibrillation receiving apixaban 5mg BID.
Taking common heart rhythm drugs with apixaban raises blood levels and increases the risk of serious bleeding that can lead to hospitalizati…
medRxiv Apr 19, 2026
In CRT recipients with persistent AF, rhythm control improved LVEF compared to rate control strategies
Cardiology RCT
In CRT recipients with persistent AF, rhythm control improved LVEF compared to rate control strategies Does fixing your heart rhythm actually improve pump function in this specific group?
This randomized trial evaluated rhythm versus rate control strategies in 43 CRT recipients with long-standing persistent AF and low biventri…
Fixing irregular heartbeats boosted heart muscle strength in patients with devices, but daily life and exercise ability improved similarly w…
Apr 9, 2026
Systematic review finds evidence gap for amiodarone in chronic Chagas cardiomyopathy
Drug Pipeline Meta-analysis
Systematic review finds evidence gap for amiodarone in chronic Chagas cardiomyopathy Review finds major research gap on heart drug amiodarone for Chagas disease
A systematic review and bibliometric analysis of 52 articles identified a significant literature gap regarding amiodarone therapy for chroni…
A review of 52 studies found a significant lack of rigorous clinical research on using the heart drug amiodarone for Chagas cardiomyopathy.
Frontiers Apr 6, 2026