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Home › Conditions › Chagas Disease

Chagas Disease

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Chagas Disease

6 trials tracked for Chagas Disease: 3 in phase 3 or 4 and 3 with published results. The most-cited published study has 515 citations.

6Trials tracked
3Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 1 Phase 3 2 Phase 2 1 Other / NA 2
  1. Phase 3 A Study to Learn How Well Nifurtimox Works and How Safe it is in Children Aged 0 to 17 Years With Chagas' Disease, an Inflammatory, Infectious Disease Caused by the Parasite Trypanosoma Cruzi Completed · 515 cited
  2. Phase 3 Short-course Benznidazole Treatment to Reduce Trypanosoma Cruzi Parasitic Load in Women of Reproductive Age Completed · 49 cited
  3. Phase 4 Efficacy and Safety of Sacubitril/Valsartan Compared With Enalapril on Morbidity, Mortality, and NT-proBNP Change in Patients With CCC Completed · 14 cited
  4. Phase 2 A Study of the Use of Oral Posaconazole (POS) in the Treatment of Asymptomatic Chronic Chagas Disease (P05267) Completed
  5. N/A Assessment of Speckle Tracking Strain Predictive Value for Myocardial Fibrosis in Chagas Disease Completed
  6. N/A Abbott ESA Chagas Assay Post-Market Study Completed

Showing the 6 most-cited and recently-updated of 6 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Chagas disease associated with higher in-hospital mortality in adults hospitalized with heart failure
Cardiology Cohort
Chagas disease associated with higher in-hospital mortality in adults hospitalized with heart failure Heart Failure Patients With Chagas Face Higher Death Risk In Hospital
This cohort study analyzed 910,128 heart failure hospitalizations within the Brazilian Unified Health System.
A massive study of nearly a million patients reveals that Chagas disease makes heart failure much more deadly inside the hospital.
medRxiv Apr 29, 2026
Systematic review finds evidence gap for amiodarone in chronic Chagas cardiomyopathy
Drug Pipeline Meta-analysis
Systematic review finds evidence gap for amiodarone in chronic Chagas cardiomyopathy Review finds major research gap on heart drug amiodarone for Chagas disease
A systematic review and bibliometric analysis of 52 articles identified a significant literature gap regarding amiodarone therapy for chroni…
A review of 52 studies found a significant lack of rigorous clinical research on using the heart drug amiodarone for Chagas cardiomyopathy.
Frontiers Apr 6, 2026
Case report describes likely first autochthonous Chagas disease case in Missouri blood donor
Hematology
Case report describes likely first autochthonous Chagas disease case in Missouri blood donor Blood donor in Missouri tests positive for Chagas disease, likely first local case
A case report describes a blood donor in Missouri with a positive screening result for Trypanosoma cruzi antibodies.
A Missouri blood donor likely represents the first local case of Chagas disease, a parasite usually found in Latin America.
CDC Apr 2, 2026

Questions about Chagas Disease

Can a blood donor in Missouri get Chagas Disease from donating blood?

A Missouri blood donor can transmit Chagas disease if they have the parasite, as shown by a 2017 case where a donor tested positive for the disease-causing parasite.

Full answer →