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Persistent Atrial Fibrillation

Part of Atrial Fibrillation

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Persistent Atrial Fibrillation

33 trials tracked for Persistent Atrial Fibrillation.

33Trials tracked
0Phase 3 & 4
0Recruiting
0With published results
Phase distribution
Phase 2 1 Other / NA 32
  1. Phase 2 Ranolazine in Atrial Fibrillation Following An ELectricaL CardiOversion Completed
  2. N/A Comparison of Pulmonary Vein Ablation With or Without Left Atrial Posterior Wall Ablation for Persistent AF (PIVoTAL) Completed
  3. N/A Investigation of Therapeutic Ablation Versus Cardioversion for AF Completed
  4. N/A AF Septal Pacing (Clinical Investigation Plan) Completed
  5. N/A Randomized Evaluation of Redo Ablation Procedures of Atrial Fibrillation With FIRM Guided Procedures Completed
  6. N/A A Study Assessing Arrhythmia Mapping With the Multi-Electrode OPTRELL™ Mapping Catheter Completed
Show 27 more trials
  1. N/A AF Substrate Mapping and Guided Ablation Completed
  2. N/A A Prospective Single Arm Open Label Study of the FARAPULSE Pulsed Field Ablation System in Subjects With Persistent Atrial Fibrillation Completed
  3. N/A DiamondTemp™ System for the Treatment of Persistent Atrial Fibrillation Completed
  4. N/A Feasibility Study of the FARAPULSE™ Cardiac Ablation System Plus in the Treatment of Persistent Atrial Fibrillation(PersAFOne II) Completed
  5. N/A Utilizing Novel Dipole Density Capabilities to Objectively Visualize the Etiology of Rhythms in Atrial Fibrillation Completed
  6. N/A Hybrid Ablation Plus Medical Therapy for Persistent Atrial Fibrillation Completed
  7. N/A Dual Epicardial Endocardial Persistent Atrial Fibrillation (AF) Study Completed
  8. N/A Single Center Pilot Study Using the ECGenius System to Collect Electrogram Data to Test an Ablation Impact Algorithm Completed
  9. N/A Modified Ablation Guided by Ibutilide Use in Chronic Atrial Fibrillation Completed
  10. N/A ABLATE Post Approval Study - Synergy Ablation Lesions for Non-Paroxysmal Atrial Fibrillation Completed
  11. N/A The FARAPULSE PersAFOne III Trial for the Treatment of Persistent Atrial Fibrillation Completed
  12. N/A Feasibility Study of the FARAPULSE Endocardial Multi Ablation System in the Treatment of Persistent Atrial Fibrillation Completed
  13. N/A A Study Assessing Arrhythmia Mapping With a Globe-Shaped, High-Density, Multi-Electrode Mapping Catheter Completed
  14. N/A Randomized Evaluation of Atrial Fibrillation Treatment With Focal Impulse and Rotor Modulation Guided Procedures Completed
  15. N/A CONVERGE - Epi/Endo Ablation For Treatment of Persistent Atrial Fibrillation(AF) Completed
  16. N/A AF-FLOW Registry to Evaluate Electrographic Flow Mapping in Patients Undergoing Ablation for Atrial Fibrillation Completed
  17. N/A Advisor HD Grid Observational Study Completed
  18. N/A FLOW EVAL-AF: FLOW Mapping Electrogram VALidation in Patients With Persistent Atrial Fibrillation Completed
  19. N/A HD Mapping of Atrial Fibrillation in Asia Pacific Completed
  20. N/A Automated Assessment of PVI Using a Novel EP Recording System Completed
  21. N/A Repetitive Activation Patterns and Focal Impulses Identification and Ablation in Persistent AF Completed
  22. N/A Safety and Effectiveness of TactiCath™ Contact Force, Sensor Enabled™ (TactiCath SE) Catheter for Ablation of Drug Refractory, Symptomatic, Persistent Atrial Fibrillation Completed
  23. N/A FLOW-AF: A Study to Evaluate Electrographic Flow™ (EGF) Mapping Technology Completed
  24. N/A A Feasibility Study to Evaluate the Effect of Concomitant Renal Denervation and Cardiac Ablation on AF Recurrence Completed
  25. N/A RADAR Clinical Trial Completed
  26. N/A A Study of Intracardiac Ultrasound With the NUVISION NAV Ultrasound Catheter Completed
  27. N/A High-Density (HD) Wave Mapping in Subjects With Atrial Fibrillation as a Predictor of Recurrence After a Single Ablation Procedure Using a PVI-Only Strategy Completed

Showing the 33 most-cited and recently-updated of 33 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Atrial Fibrillation

Related studies from across the Atrial Fibrillation family.

Higher Triglyceride-glucose index levels are associated with increased risk of Atrial Fibrillation
Cardiology Meta-analysis
Higher Triglyceride-glucose index levels are associated with increased risk of Atrial Fibrillation Higher Triglyceride-Glucose Index Linked to Increased Risk of Atrial Fibrillation
This meta-analysis of 25,376 individuals found significantly higher TyG index levels in patients with Atrial Fibrillation compared to those …
A high triglyceride-glucose index may serve as a potential marker for identifying people at risk for atrial fibrillation and related heart c…
Sarcopenia linked to 2.16-fold higher odds of atrial fibrillation in meta-analysis
Rheumatology Meta-analysis
Sarcopenia linked to 2.16-fold higher odds of atrial fibrillation in meta-analysis Muscle loss linked to higher risk of irregular heartbeats
A meta-analysis of over 3 million patients found sarcopenia associated with significantly higher odds of atrial fibrillation (OR 2.16; 95% C…
A large study involving over 3 million people found that muscle loss, known as sarcopenia, is linked to a higher risk of developing atrial f…
Antazoline May Beat Propafenone and Amiodarone for AF Conversion
Cardiology Meta-analysis
Antazoline May Beat Propafenone and Amiodarone for AF Conversion Antazoline shows better results for atrial fibrillation heart rhythms
A meta-analysis suggests antazoline is more effective than propafenone or amiodarone for converting atrial fibrillation to sinus rhythm, wit…
A new review suggests antazoline may be more effective than common medications at restoring normal heart rhythms for patients with atrial fi…
Catheter ablation reduces atrial fibrillation recurrence compared to anti-arrhythmic drugs in paroxysmal and persistent cases
Cardiology Meta-analysis
Catheter ablation reduces atrial fibrillation recurrence compared to anti-arrhythmic drugs in paroxysmal and persistent cases Catheter Ablation Shows Lower Recurrence Rates for Atrial Fibrillation
This systematic review and meta-analysis of randomized controlled trials compares catheter ablation to anti-arrhythmic drugs (AAD) for manag…
A review of clinical trials suggests catheter ablation may lead to lower heart rhythm recurrence rates compared to anti-arrhythmic drugs.
Cardiac rehabilitation reduces atrial fibrillation recurrence (RR 0.77) and improves exercise capacity in patients
Cardiology Meta-analysis
Cardiac rehabilitation reduces atrial fibrillation recurrence (RR 0.77) and improves exercise capacity in patients Cardiac Rehabilitation May Reduce Recurrence of Atrial Fibrillation
This meta-analysis of randomized controlled trials involving 1550 patients found that cardiac rehabilitation significantly reduced overall a…
A review of clinical trials suggests that cardiac rehabilitation can lower the risk of atrial fibrillation returning and improve exercise ca…
Pulsed field ablation reduces procedure time compared to very high-power short-duration ablation in atrial fibrillation
Cardiology Meta-analysis
Pulsed field ablation reduces procedure time compared to very high-power short-duration ablation in atrial fibrillation Pulsed field ablation speeds up heart surgery for atrial fibrillation
This meta-analysis of 11 observational studies evaluated pulsed field ablation (PFA) against very high-power short-duration ablation (vHPSD)…
A newer technique called pulsed field ablation can significantly shorten procedure times for patients undergoing heart surgery to treat irre…
Rhythm control for postcardiac surgery atrial fibrillation shows higher conversion rates but increased risks
Cardiology Meta-analysis
Rhythm control for postcardiac surgery atrial fibrillation shows higher conversion rates but increased risks Rhythm Control Shows Higher Risks for Post-Surgery Heart Patients
Researchers evaluated the clinical impact of rhythm control versus rate control in patients with atrial fibrillation following cardiac surge…
Aggressive heart rhythm treatments may increase the risk of side effects like low blood pressure in patients following heart surgery.
Inadequate sleep duration is associated with higher risk of atrial flutter recurrence after ablation
Cardiology RCT
Inadequate sleep duration is associated with higher risk of atrial flutter recurrence after ablation Short or long sleep may increase risk of heart rhythm issues
This multicentre randomized controlled trial of 720 patients undergoing catheter ablation for atrial fibrillation found no significant assoc…
Patients with atrial fibrillation who get less than 6 hours or more than 8 hours of sleep face a higher risk of specific heart rhythm recurr…
Left atrial appendage electrical isolation combined with pulmonary vein isolation reduces recurrent atrial arrhythmia
Cardiology Meta-analysis
Left atrial appendage electrical isolation combined with pulmonary vein isolation reduces recurrent atrial arrhythmia Adding Electrical Isolation Reduces Recurrent Arrhythmia in Atrial Fibrillation
This meta-analysis evaluated the addition of left atrial appendage electrical isolation to standard pulmonary vein isolation for patients wi…
A new analysis shows that adding electrical isolation to standard procedures can significantly lower the risk of recurring heart rhythm issu…
Patients with cardiovascular diseases show measurable prevalence of active cancer across multiple conditions
Cardiology Sys. Review
Patients with cardiovascular diseases show measurable prevalence of active cancer across multiple conditions Heart disease patients show measurable risk of developing various cancers
This systematic review and meta-analysis analyzed 4,759,695 patients to determine the prevalence of active cancer in individuals with variou…
New data shows that people with heart conditions like stroke or heart failure have a measurable rate of active cancer cases.
Macrophage migration inhibitory factor serves as a potential biomarker and therapeutic target for atrial fibrillation
Cardiology Sys. Review
Macrophage migration inhibitory factor serves as a potential biomarker and therapeutic target for atrial fibrillation Protein levels may predict heart failure and stroke risks
This systematic review synthesizes evidence regarding macrophage migration inhibitory factor (MIF) in the context of atrial fibrillation and…
A specific protein called MIF is linked to heart damage and can help doctors predict serious complications like stroke or heart failure.
Electrical cardioversion and catheter ablation are safe and effective for arrhythmias in pregnant women
Cardiology Meta-analysis
Electrical cardioversion and catheter ablation are safe and effective for arrhythmias in pregnant women Catheter Ablation and Cardioversion Show Success for Pregnant Women
This narrative review synthesizes evidence regarding electrical cardioversion and catheter ablation for managing arrhythmias during pregnanc…
New data shows that both electrical cardioversion and catheter ablation are effective ways to treat heart rhythm issues in pregnant patients…

Questions about Persistent Atrial Fibrillation

Can ethanol infusion during ablation improve rhythm maintenance for patients with persistent atrial fibrillation?

Yes, adding ethanol infusion in the vein of Marshall during ablation improves sinus rhythm maintenance in persistent AF patients, with a 17% absolute benefit at 1 year.

Full answer →
What is the success rate for sinus rhythm when adding rotational activity ablation for persistent AF?

Adding rotational activity ablation to standard procedures increases the rate of sinus rhythm maintenance to 91.5% in persistent AF patients, compared to lower rates with standard ablation alone.

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Does VOM ethanol infusion help keep a normal heart rhythm in persistent atrial fibrillation?

Adding VOM ethanol infusion to standard catheter ablation improves the chance of keeping a normal heart rhythm in persistent atrial fibrillation.

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