Protocol for comparing azithromycin and doxycycline with beta-lactams in community-acquired pneumonia
New trial to test azithromycin vs doxycycline for pneumonia
This is a protocol for a planned randomized clinical trial involving 1120 adult patients hospitalized with community-acquired pneumonia. No …
A large trial will compare two antibiotic combos for hospitalized pneumonia patients. Which works better?
Genome-predicted PBP profiling shows high agreement with phenotypic testing for pneumococcal beta-lactam susceptibility
Genome test predicts pneumococcal antibiotic resistance accurately
This mini review evaluates the use of genome-predicted beta-lactam susceptibility based on PBP1a, PBP2b, and PBP2x to predict drug-specific …
A new review finds that genome-based testing can accurately predict whether pneumococcal bacteria will resist beta-lactam antibiotics.
Gram-negative organisms and multidrug resistance are prevalent in dental unit waterlines
Bacteria in dental water lines show resistance to common antibiotics
This scoping review of 18 studies identifies a prevalence of Gram-negative organisms, such as Pseudomonas spp., in dental unit waterlines. T…
Research shows that bacteria found in dental unit waterlines can resist several common types of antibiotics used to treat infections.
Positive in vitro interactions with β-lactam linked to lower 14-day mortality in MRSA bacteraemia
Positive lab interactions linked to lower early death in MRSA infection treatment
This post hoc analysis of a multicentre randomized trial included 150 adults with MRSA bacteraemia.
When lab tests showed bacteria died better with combined drugs, patients had lower early death rates. This finding suggests smarter drug pai…
Scoping review shows WHO Access antibiotic susceptibility remains low in Pakistan clinical isolates
Pakistan's antibiotic resistance crisis threatens global health goals
This scoping review synthesizes data from 74 studies involving human clinical isolates in Pakistan.
Common infections in Pakistan are becoming harder to treat because most first-line antibiotics no longer work, threatening a key global heal…
Short-course beta-lactam prophylaxis reduces early-onset VAP in mechanically ventilated patients with acute brain injury
Short Antibiotics Cut Early Lung Infections in Brain Injury Patients
This systematic review and meta-analysis evaluated short-course systemic beta-lactam antibiotic prophylaxis versus control in 1,673 mechanic…
Short antibiotic courses cut early lung infections in brain injury patients on ventilators, reducing hospital stays without increasing death…