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Home › Medications › isotretinoin

isotretinoin

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of isotretinoin

19 trials tracked of isotretinoin: 9 in phase 3 or 4 and 6 with published results. The most-cited published study has 1834 citations.

19Trials tracked
9Phase 3 & 4
0Recruiting
6With published results
Phase distribution
Phase 4 3 Phase 3 6 Phase 2 9 Phase 1 1
  1. Phase 3 Isotretinoin With or Without Dinutuximab, Aldesleukin, and Sargramostim Following Stem Cell Transplant in Treating Patients With Neuroblastoma Completed · 1,834 cited
  2. Phase 3 Comparing Two Different Myeloablation Therapies in Treating Young Patients Who Are Undergoing a Stem Cell Transplant for High-Risk Neuroblastoma Completed · 369 cited
  3. Phase 3 Combination Chemotherapy and Surgery With or Without Isotretinoin in Treating Young Patients With Neuroblastoma Completed · 130 cited
  4. Phase 3 Efficacy & Safety Comparison of Epiduo With Doxycycline Versus Vehicle With Isotretinoin in the Treatment of Severe Acne Completed · 52 cited
  5. Phase 4 ABSORICA in Patients With Severe Recalcitrant Nodular Acne Completed · 13 cited
  6. Phase 4 Effects of Isotretinoin on CYP2D6 Activity Completed · 1 cited
Show 13 more trials
  1. Phase 4 Isotretinoin for Proliferative Vitreoretinopathy Completed
  2. Phase 3 Efficacy and Safety of CIP-Isotretinoin in Patients With Severe Recalcitrant Nodular Acne Completed
  3. Phase 3 Monoclonal Antibody Ch14.18, Sargramostim, Aldesleukin, and Isotretinoin After Autologous Stem Cell Transplant in Treating Patients With Neuroblastoma Completed
  4. Phase 2 A Vehicle Controlled Study to Evaluate Safety and Efficacy of Topical TMB-001 for Treatment of Congenital Ichthyosis Completed
  5. Phase 2 Effect of Isotretinoin on Immune Activation Among HIV-1 Infected Subjects With Incomplete CD4+ T Cell Recovery Completed
  6. Phase 2 ch14.18 Pharmacokinetic Study in High-risk Neuroblastoma Completed
  7. Phase 2 Podocyte Retinoids Completed
  8. Phase 2 Therapy for Children With Advanced Stage Neuroblastoma Completed
  9. Phase 2 Biological Therapy, Sargramostim, and Isotretinoin in Treating Patients With Relapsed or Refractory Neuroblastoma Completed
  10. Phase 2 Weekly Isotretinoin Therapy Study Completed
  11. Phase 2 Temozolomide Alone or in Combination With Thalidomide and/or Isotretinoin and/or Celecoxib in Treating Patients Who Have Undergone Radiation Therapy for Glioblastoma Multiforme Completed
  12. Phase 2 Dinutuximab, Sargramostim, and Combination Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Completed
  13. Phase 1 Induction Therapy Including 131 I-MIBG and Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant, Radiation Therapy, and Maintenance Therapy With Isotretinoin Completed

Showing the 19 most-cited and recently-updated of 19 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Retinoic acid signaling and RAR antagonists impact chondrocyte maturation and growth plate senescence
Pediatrics Sys. Review
Retinoic acid signaling and RAR antagonists impact chondrocyte maturation and growth plate senescence Retinoic Acid Signaling Impacts Growth Plate Development and Closure
This narrative review examines the role of retinoic acid (RA) signaling and RAR antagonists in growth plate physiology. The authors conclude…
Research shows how retinoic acid levels affect bone growth plates, which could impact how we treat growth issues in children.
Frontiers Oct 8, 2026
Skin lesions typically precede spinal arthritis in patients with follicular occlusion triad and spondyloarthritis
Gastroenterology Sys. Review
Skin lesions typically precede spinal arthritis in patients with follicular occlusion triad and spondyloarthritis Skin issues may signal upcoming spinal arthritis in some patients
This case report and literature review examines the clinical patterns of peripheral and axial spondyloarthritis in patients with follicular …
New data shows that skin lesions often appear years before spinal arthritis begins in patients with specific inflammatory conditions.
Frontiers Aug 25, 2026
Phase II pilot study of hu14.18K322A plus chemotherapy in 153 children with high-risk neuroblastoma
Pediatrics Phase II
Phase II pilot study of hu14.18K322A plus chemotherapy in 153 children with high-risk neuroblastoma New Antibody Boosts Survival in High-Risk Neuroblastoma
This Phase II pilot study enrolled 153 previously untreated children with high-risk neuroblastoma. The study assessed hu14.18K322A combined …
This study shows that combining a new antibody with standard chemotherapy may improve survival rates for children with high-risk neuroblasto…
CT.gov Jun 4, 2026