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Home › Medications › lamotrigine

lamotrigine

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of lamotrigine

33 trials tracked of lamotrigine: 19 in phase 3 or 4 and 5 with published results. The most-cited published study has 636 citations.

33Trials tracked
19Phase 3 & 4
0Recruiting
5With published results
Phase distribution
Phase 4 10 Phase 3 9 Phase 2 3 Phase 1 4 Other / NA 7
  1. Phase 3 Childhood Absence Epilepsy Rx PK-PD-Pharmacogenetics Study Completed · 636 cited
  2. Phase 4 Research Study for Major Depressive Disorder: Investigation of Glutamate Medications Completed · 599 cited
  3. Phase 3 Lamotrigine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer Completed · 193 cited
  4. Phase 4 Sequential Multiple Assignment Treatment for Bipolar Disorder Completed · 28 cited
  5. Phase 3 Lamotrigine Phase III Study in Bipolar I Disorder Completed · 4 cited
  6. Phase 4 An Open-Label Extension Study Of Lamotrigine In Subjects With Bipolar Disorder Completed
Show 27 more trials
  1. Phase 4 Reversing Corticosteroid Induced Memory Impairment Completed
  2. Phase 4 Treatment of Alcohol Dependence and Comorbid Bipolar Disorder Completed
  3. Phase 4 Melancholic Symptoms in Bipolar Depression and Responsiveness to Lamotrigine Completed
  4. Phase 4 Study on the Treatment of Elderly Patients With Older and Newer Antiepileptic Drugs Completed
  5. Phase 4 Lamotrigine add-on Therapy for Bipolar Disorder and Cocaine Dependency Completed
  6. Phase 4 Lamotrigine for the Treatment of Mania in Youth Ages 6-17 With Bipolar Disorder Completed
  7. Phase 4 Maintenance Treatment of Bipolar Depression Completed
  8. Phase 3 An Open-Label Trial Measuring Satisfaction And Convenience Of Two Formulations Of Lamotrigine In Subjects With A Mood Disorder Completed
  9. Phase 3 Study Of The Safety And Efficacy Of Lyrica In The Treatment Of Newly Diagnosed Partial Epilepsy Completed
  10. Phase 3 Lamotrigine Extended-Release In Elderly Patients With Epilepsy Completed
  11. Phase 3 A Study for Evaluating the Efficacy and Safety of Zonisamide and Lamotrigine (Lamictal) for Subjects With Refractory Simple Partial, Complex Partial or Partial With Secondary Generalized Seizures Completed
  12. Phase 3 An Evaluation Of BW430C (Lamotrigine) Versus Placebo In The Prevention Of Mood Episodes In Bipolar I Disorder Patients Completed
  13. Phase 3 Bipolar Depression Before and After Lamotrigine Treatment Completed
  14. Phase 2 Enhancing the Effects of Alcohol Treatment With Lamotrigine Completed
  15. Phase 2 Study of Lamotrigine to Treat Ménière's Disease Completed
  16. Phase 2 Lamotrigine Monotherapy in Pediatric Bipolar Disorder Completed
  17. Phase 1 Bioequivalence Study of 200 mg Lamotrigine Tablet Under Fasting Conditions Completed
  18. Phase 1 A Study in Healthy Men to Test Whether BI 409306, BI 425809 or Lamotrigine Can Reverse the Memory Problems Caused by Ketamine Completed
  19. Phase 1 Bioequivalence Study of 200 mg Lamotrigine Tablet Under Non-Fasting Conditions Completed
  20. Phase 1 A Study in Participants With Epilepsy, to Evaluate the Pharmacokinetics, Safety and Tolerability of Oxcarbazepine on Padsevonil Completed
  21. N/A PET and MRI Brain Imaging of Bipolar Disorder Completed
  22. N/A Cognitive Effects of Treatment of Interictal Discharges Completed
  23. N/A Premenstrual Dysphoric Disorder and Antiepileptic Drugs Completed
  24. N/A Decision-Making in Bipolar Disorder Completed
  25. N/A Evaluation of Lamotrigine on Neuropathic Facial Pain Using fMRI Completed
  26. N/A Lamotrigine Therapy in Geriatric Bipolar Depression Completed
  27. N/A Research Study to Test Safety and Effectiveness of Investigational Drug in Patients With Trigeminal Neuralgia Completed

Showing the 33 most-cited and recently-updated of 33 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Systematic review and meta-analysis of mood stabilizers for nonsuicidal self-injury in adolescents
Psychiatry Meta-analysis
Systematic review and meta-analysis of mood stabilizers for nonsuicidal self-injury in adolescents Mood stabilizers show promise for teen self-injury and depression in China
This systematic review and meta-analysis examined nine studies from China involving adolescent patients with nonsuicidal self-injury. The au…
A review of nine studies suggests mood stabilizers may help reduce self-injury and depression in Chinese adolescents, offering new options f…
May 20, 2026
FDA Approves Lamotrigine for Adjunctive Therapy in Epilepsy and Maintenance in Bipolar I Disorder
Neurology FDA Approval
FDA Approves Lamotrigine for Adjunctive Therapy in Epilepsy and Maintenance in Bipolar I Disorder FDA approves lamotrigine, a medicine for epilepsy and bipolar disorder
Lamotrigine is approved for adjunctive therapy of partial-onset seizures, PGTC seizures, and seizures of Lennox-Gastaut syndrome in patients…
The FDA officially approves lamotrigine for epilepsy and bipolar disorder, confirming a long-used treatment option for adults and children a…
FDA Apr 2, 2026