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Home › Medications › lamotrigine

lamotrigine

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of lamotrigine

33 trials tracked of lamotrigine: 19 in phase 3 or 4 and 5 with published results. The most-cited published study has 644 citations.

33Trials tracked
19Phase 3 & 4
0Recruiting
5With published results
Phase distribution
Phase 4 10 Phase 3 9 Phase 2 3 Phase 1 4 Other / NA 7
  1. Phase 3 Childhood Absence Epilepsy Rx PK-PD-Pharmacogenetics Study Completed · 644 cited
  2. Phase 4 Research Study for Major Depressive Disorder: Investigation of Glutamate Medications Completed · 602 cited
  3. Phase 3 Lamotrigine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer Completed · 195 cited
  4. Phase 4 Sequential Multiple Assignment Treatment for Bipolar Disorder Completed · 29 cited
  5. Phase 3 Lamotrigine Phase III Study in Bipolar I Disorder Completed · 5 cited
  6. Phase 4 An Open-Label Extension Study Of Lamotrigine In Subjects With Bipolar Disorder Completed
Show 27 more trials
  1. Phase 4 Reversing Corticosteroid Induced Memory Impairment Completed
  2. Phase 4 Treatment of Alcohol Dependence and Comorbid Bipolar Disorder Completed
  3. Phase 4 Melancholic Symptoms in Bipolar Depression and Responsiveness to Lamotrigine Completed
  4. Phase 4 Study on the Treatment of Elderly Patients With Older and Newer Antiepileptic Drugs Completed
  5. Phase 4 Lamotrigine add-on Therapy for Bipolar Disorder and Cocaine Dependency Completed
  6. Phase 4 Lamotrigine for the Treatment of Mania in Youth Ages 6-17 With Bipolar Disorder Completed
  7. Phase 4 Maintenance Treatment of Bipolar Depression Completed
  8. Phase 3 An Open-Label Trial Measuring Satisfaction And Convenience Of Two Formulations Of Lamotrigine In Subjects With A Mood Disorder Completed
  9. Phase 3 Study Of The Safety And Efficacy Of Lyrica In The Treatment Of Newly Diagnosed Partial Epilepsy Completed
  10. Phase 3 Lamotrigine Extended-Release In Elderly Patients With Epilepsy Completed
  11. Phase 3 A Study for Evaluating the Efficacy and Safety of Zonisamide and Lamotrigine (Lamictal) for Subjects With Refractory Simple Partial, Complex Partial or Partial With Secondary Generalized Seizures Completed
  12. Phase 3 An Evaluation Of BW430C (Lamotrigine) Versus Placebo In The Prevention Of Mood Episodes In Bipolar I Disorder Patients Completed
  13. Phase 3 Bipolar Depression Before and After Lamotrigine Treatment Completed
  14. Phase 2 Enhancing the Effects of Alcohol Treatment With Lamotrigine Completed
  15. Phase 2 Study of Lamotrigine to Treat Ménière's Disease Completed
  16. Phase 2 Lamotrigine Monotherapy in Pediatric Bipolar Disorder Completed
  17. Phase 1 Bioequivalence Study of 200 mg Lamotrigine Tablet Under Fasting Conditions Completed
  18. Phase 1 A Study in Healthy Men to Test Whether BI 409306, BI 425809 or Lamotrigine Can Reverse the Memory Problems Caused by Ketamine Completed
  19. Phase 1 Bioequivalence Study of 200 mg Lamotrigine Tablet Under Non-Fasting Conditions Completed
  20. Phase 1 A Study in Participants With Epilepsy, to Evaluate the Pharmacokinetics, Safety and Tolerability of Oxcarbazepine on Padsevonil Completed
  21. N/A PET and MRI Brain Imaging of Bipolar Disorder Completed
  22. N/A Cognitive Effects of Treatment of Interictal Discharges Completed
  23. N/A Premenstrual Dysphoric Disorder and Antiepileptic Drugs Completed
  24. N/A Decision-Making in Bipolar Disorder Completed
  25. N/A Evaluation of Lamotrigine on Neuropathic Facial Pain Using fMRI Completed
  26. N/A Lamotrigine Therapy in Geriatric Bipolar Depression Completed
  27. N/A Research Study to Test Safety and Effectiveness of Investigational Drug in Patients With Trigeminal Neuralgia Completed

Showing the 33 most-cited and recently-updated of 33 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Glutamatergic agents show preclinical promise in Multiple Sclerosis but fail in clinical trials
Neurology Sys. Review
Glutamatergic agents show preclinical promise in Multiple Sclerosis but fail in clinical trials Laboratory tests show promise for multiple sclerosis but face hurdles
This narrative review examines the efficacy of glutamatergic agents in experimental autoimmune encephalomyelitis models versus human clinica…
Certain drugs showed success in lab models for multiple sclerosis, but these same medicines failed to work during actual human clinical tria…
Frontiers Aug 11, 2026
Systematic review and meta-analysis of mood stabilizers for nonsuicidal self-injury in adolescents
Psychiatry Meta-analysis
Systematic review and meta-analysis of mood stabilizers for nonsuicidal self-injury in adolescents Mood stabilizers show promise for teen self-injury and depression in China
This systematic review and meta-analysis examined nine studies from China involving adolescent patients with nonsuicidal self-injury. The au…
A review of nine studies suggests mood stabilizers may help reduce self-injury and depression in Chinese adolescents, offering new options f…
May 20, 2026
FDA Approves Lamotrigine for Adjunctive Therapy in Epilepsy and Maintenance in Bipolar I Disorder
Neurology FDA Approval
FDA Approves Lamotrigine for Adjunctive Therapy in Epilepsy and Maintenance in Bipolar I Disorder FDA approves lamotrigine, a medicine for epilepsy and bipolar disorder
Lamotrigine is approved for adjunctive therapy of partial-onset seizures, PGTC seizures, and seizures of Lennox-Gastaut syndrome in patients…
The FDA officially approves lamotrigine for epilepsy and bipolar disorder, confirming a long-used treatment option for adults and children a…
FDA Apr 2, 2026