Efficacy of Levodopa Based Therapy for Motor and Cognitive Recovery After Stroke
Levodopa does not improve movement after a stroke
A meta-analysis involving 1,257 patients found that adding levodopa to standard stroke rehabilitation yields no significant improvement in m…
A large review of stroke recovery shows that adding levodopa to rehabilitation does not improve physical movement, mood, or thinking.
Safinamide 100 mg outperforms rasagiline 1 mg and zonisamide 25 mg for motor fluctuations
Safinamide beats rasagiline for Parkinson's motor symptoms
This network meta-analysis of randomized controlled trials evaluated various adjunct therapies for Asian Parkinson's disease patients with m…
For Asian Parkinson's patients, adding safinamide to levodopa reduces OFF-time more than rasagiline or zonisamide.
Continuous subcutaneous foslevodopa/foscarbidopa improves off time in Parkinson's disease; severe adverse events higher in prior DBS group
Patients with Parkinsons disease who had prior brain surgery saw more side effects while using new skin patches
This post hoc analysis of an open-label phase 3 trial evaluated continuous subcutaneous infusion of foslevodopa/foscarbidopa in 244 patients…
A new look at trial data shows skin patches help Parkinsons patients move better and sleep longer. However, those who had brain surgery earl…
Prasinezumab showed non-significant delay in motor progression versus placebo in early-stage Parkinson's disease
Early Parkinson's drug trial shows no delay in motor progression
This phase 2b trial evaluated intravenous prasinezumab in individuals with early-stage Parkinson's disease on stable medication. The study f…
A Phase 2b trial of prasinezumab in early Parkinson's disease failed to meet its primary endpoint of delaying motor progression compared to …
Deep brain stimulation improves motor function and reduces levodopa needs in Parkinson's disease patients regardless of GBA mutation status
Deep brain stimulation helps Parkinson's patients but GBA mutation carriers face faster cognitive decline
A systematic review found that deep brain stimulation significantly enhanced motor function and lowered medication requirements for Parkinso…
Deep brain stimulation improves movement and lowers medication needs for Parkinson's patients, yet those with GBA mutations show faster thin…
CSF SAA status associates with levodopa responsiveness and motor progression in Parkinson's disease patients
Parkinson’s test predicts levodopa response and motor decline speed
This observational cohort study analyzed 223 sporadic Parkinson's disease participants from the PPMI cohort initiating levodopa.
Test reveals Parkinson’s patients with alpha-synuclein seeds respond better to levodopa and decline slower than those without the seeds.
Hypothesis links cumulative levodopa exposure to frailty and reduced healthspan in Parkinson's disease
Researchers propose cumulative levodopa exposure may increase health complications in Parkinson’s disease
A hypothesis proposes that cumulative levodopa exposure in patients with Parkinson's disease may contribute to frailty and reduced healthspa…
Parkinson's patients on long-term levodopa face higher risks of dementia, falls, and death, echoing how other life-saving drugs later showed…
Review of arginine and levodopa stimulation testing reports hematuria in pediatric patients
Red urine after a growth test? Here is what you need to know
This case report and literature review examines hematuria associated with combined arginine and levodopa growth hormone stimulation testing …
A simple growth test can sometimes turn urine red, but it is not dangerous and resolves quickly with rest and water.