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Home › Medications › levothyroxine

levothyroxine

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of levothyroxine

13 trials tracked of levothyroxine: 3 in phase 3 or 4 and 2 with published results. The most-cited published study has 462 citations.

13Trials tracked
3Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 1 Phase 3 2 Phase 2 5 Other / NA 5
  1. Phase 3 Thyroid Therapy for Mild Thyroid Deficiency in Pregnancy Completed · 462 cited
  2. Phase 4 Discontinuation of Levothyroxine Therapy for Patients With Subclinical Hypothyroidism Completed · 5 cited
  3. Phase 3 Early Levothyroxine Post Radioactive Iodine Completed
  4. Phase 2 Energy Metabolism in Thyroidectomized Patients Completed
  5. Phase 2 A Study of Armour® Thyroid Compared to Synthetic T4 (Levothyroxine) in Previously Hypothyroid Participants Completed
  6. Phase 2 Effects of Liothyronine on Energy Expenditure and Cardiovascular Function Completed
Show 7 more trials
  1. Phase 2 Sunitinib or Cediranib for Alveolar Soft Part Sarcoma Completed
  2. Phase 2 Study of XP-8121 For the Treatment of Adult Subjects With Hypothyroidism Completed
  3. N/A Quality of Life After Interventional Thyroid Treatment Completed
  4. N/A Targeted Levothyroxine Dosing in Infants With Congenital Hypothyroidism Completed
  5. N/A Treatment Trial of Subclinical Hypothyroidism in Down Syndrome Completed
  6. N/A Mechanistic Study of Subclinical Hypothyroidism In the Elderly Completed
  7. N/A Thyroid Hormone Dose Adjustment in Pregnancy Completed

Showing the 13 most-cited and recently-updated of 13 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
FDA Approves Levothyroxine Sodium Tablets for Hypothyroidism and TSH Suppression
Diabetes & Endocrinology FDA Approval
FDA Approves Levothyroxine Sodium Tablets for Hypothyroidism and TSH Suppression FDA approves new thyroid hormone drug for hypothyroidism and thyroid cancer.
The FDA approved levothyroxine sodium tablets for replacement therapy in primary, secondary, and tertiary hypothyroidism, and as an adjunct …
The FDA has approved levothyroxine sodium tablets to treat hypothyroidism and as part of therapy for certain thyroid cancers. This synthetic…
FDA May 6, 2026
Nurse-led care coordination fails to improve medication adherence in high-need patients
Cardiology RCT
Nurse-led care coordination fails to improve medication adherence in high-need patients Nurse-led care coordination did not improve medication adherence for most common chronic conditions
This pragmatic randomized controlled trial tested nurse-led care coordination versus usual care in high-need, high-cost commercially insured…
A large trial found that nurse-led care coordination did not improve how often people took their diabetes, heart, or thyroid medications com…
May 1, 2026
Meta-analysis shows associations between hypothyroidism and increased chronic kidney disease prevalence
Diabetes & Endocrinology Meta-analysis
Meta-analysis shows associations between hypothyroidism and increased chronic kidney disease prevalence Hypothyroidism Linked To Kidney Issues But Treatment Does Not Fix Them
This meta-analysis of 46 studies examines the relationship between hypothyroidism, including subclinical cases, and kidney outcomes.
Untreated low thyroid levels are strongly tied to worse kidney function in adults, but taking thyroid medicine does not seem to improve kidn…
Frontiers May 1, 2026