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Home › Medications › mercaptopurine

mercaptopurine

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of mercaptopurine

33 trials tracked of mercaptopurine: 15 in phase 3 or 4 and 9 with published results. The most-cited published study has 248 citations.

33Trials tracked
15Phase 3 & 4
0Recruiting
9With published results
Phase distribution
Phase 3 15 Phase 2 15 Phase 1 2 Other / NA 1
  1. Phase 3 Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed · 248 cited
  2. Phase 3 05-001: Treatment of Acute Lymphoblastic Leukemia in Children Completed · 238 cited
  3. Phase 3 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed · 226 cited
  4. Phase 3 Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma Completed · 100 cited
  5. Phase 3 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations Completed · 84 cited
  6. Phase 3 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma Completed · 57 cited
Show 27 more trials
  1. Phase 3 Low-Dose or High-Dose Vincristine and Combination Chemotherapy in Treating Young Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia Completed · 48 cited
  2. Phase 3 Calaspargase Pegol or Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia Completed · 46 cited
  3. Phase 3 Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed · 36 cited
  4. Phase 3 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Promyelocytic Leukemia Completed
  5. Phase 3 Dexamethasone Compared With Prednisone During Induction Therapy and Methotrexate With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia Completed
  6. Phase 3 Combination Chemotx in Treating Children or Adolescents With Newly Diagnosed Stg III or Stg IV Lymphoblastic Lymphoma Completed
  7. Phase 3 Comparison of Two Combination Chemotherapy Regimens With Either Vincristine or Vinblastine in Treating Patients With Advanced Anaplastic Large Cell Lymphoma Completed
  8. Phase 3 Comparison of Two Combination Chemotherapy Regimens in Treating Adults With Previously Untreated Leukemia or Lymphoma Completed
  9. Phase 3 S0521, Combination Chemotherapy With or Without Gemtuzumab Followed By Tretinoin, Mercaptopurine, and Methotrexate or Observation in Treating Patients With Acute Promyelocytic Leukemia Completed
  10. Phase 2 A Study to Evaluate the Efficacy and Safety of Daratumumab in Pediatric and Young Adult Participants Greater Than or Equal to (>=)1 and Less Than or Equal to (<=) 30 Years of Age With Relapsed/Refractory Precursor B-cell or T-cell Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma Completed
  11. Phase 2 Treatment of Older Adults With Acute Lymphoblastic Leukemia Completed
  12. Phase 2 NHL16: Study For Newly Diagnosed Patients With Acute Lymphoblastic Lymphoma Completed
  13. Phase 2 S0535, Gemtuzumab and Combination Chemotherapy in Treating Patients With Previously Untreated Acute Promyelocytic Leukemia Completed
  14. Phase 2 A Clinical Trial in Patients With Breast Cancer Susceptibility Gene (BRCA) Defective Tumours Completed
  15. Phase 2 S0333 Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed
  16. Phase 2 CINJALL: Treatment for Children With Acute Lymphocytic Leukemia Completed
  17. Phase 2 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed
  18. Phase 2 Chemotherapy With or Without Imatinib and/or Peripheral Stem Cell Transplant in Acute Lymphoblastic Leukemia Completed
  19. Phase 2 Augmented Berlin-Frankfurt-Munster (BFM) Therapy for Adolescent/Young Adults With Acute Lymphoblastic Leukemia or Acute Lymphoblastic Lymphoma Completed
  20. Phase 2 Azacitidine and Combination Chemotherapy in Treating Infants With Acute Lymphoblastic Leukemia and KMT2A Gene Rearrangement Completed
  21. Phase 2 Alemtuzumab and Combination Chemotherapy in Treating Patients With Untreated Acute Lymphoblastic Leukemia Completed
  22. Phase 2 Therapy for Pediatric Relapsed or Refractory Precursor B-Cell Acute Lymphoblastic Leukemia and Lymphoma Completed
  23. Phase 2 NOPHO ALL-2008 Pilot Study on Consolidation Therapy for Children and Adolescents With Acute Lymphoblastic Leukemia Completed
  24. Phase 2 Dasatinib Followed by Stem Cell Transplant in Treating Older Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed
  25. Phase 1 Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia (Closed to Accrual 4-22-2011) Completed
  26. Phase 1 Study of Carfilzomib in Combination With Induction Chemotherapy in Children With Relapsed or Refractory Acute Lymphoblastic Leukemia Completed
  27. N/A Combination Chemotherapy and Radiation Therapy in Treating Patients With Acute Lymphoblastic Leukemia That Has Relapsed in the CNS or Testes Completed

Showing the 33 most-cited and recently-updated of 33 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Review discusses pharmacogenomic biomarkers for pediatric B-ALL chemotherapy dosing
Drug Pipeline Sys. Review
Review discusses pharmacogenomic biomarkers for pediatric B-ALL chemotherapy dosing New review looks at using genetic tests to adjust cancer drug doses for kids
This narrative review examines the role of pharmacogenomic biomarkers and genotype-guided dose adjustments in pediatric B-cell acute lymphob…
A recent review suggests that checking specific genes before treatment can help doctors give the right amount of chemotherapy to children wi…
Frontiers May 24, 2026
Pharmacogenomic adherence low in paediatric cancer despite actionable recommendations
Genetics & Precision Medicine RCT
Pharmacogenomic adherence low in paediatric cancer despite actionable recommendations Doctors Often Ignore Genetic Test Results for Kids with Cancer
This cohort analysis within the MARVEL-PIC RCT assessed clinician adherence to pharmacogenomic recommendations for 216 children with cancer.
Even when genetic tests tell doctors exactly how to adjust a child’s cancer medication, they often don’t listen—and that puts kids at risk.
medRxiv Apr 23, 2026
Systematic Review and Network Meta-Analysis Compares Enteral Nutrition and Medications in Pediatric Crohn's Disease
Pediatrics Meta-analysis
Systematic Review and Network Meta-Analysis Compares Enteral Nutrition and Medications in Pediatric Crohn's Disease Exclusive nutrition therapy beats steroids for healing Crohn's in kids
This systematic review and network meta-analysis evaluates enteral nutrition versus immunomodulators and corticosteroids in 1,182 pediatric …
Exclusive nutrition therapy was far better than steroids at healing Crohn's disease in children, with fewer side effects and no serious risk…
Frontiers Apr 22, 2026
Guselkumab showed improved clinical remission in refractory ulcerative colitis versus placebo
Drug Pipeline RCT
Guselkumab showed improved clinical remission in refractory ulcerative colitis versus placebo Guselkumab shows promise for ulcerative colitis in this early phase 3 trial
This phase 3 randomized trial evaluated guselkumab in adults with moderately to severely active ulcerative colitis who had inadequate respon…
Patients with ulcerative colitis who failed other treatments achieved remission in a new trial using subcutaneous guselkumab injections.
Apr 15, 2026
6-MP mini-tablets show bioequivalence to reference tablets in fasted children with ALL
Oncology RCT
6-MP mini-tablets show bioequivalence to reference tablets in fasted children with ALL A Tiny New Pill Could Transform Cancer Care for Children
Two open-label, randomized, crossover trials in children with acute lymphoblastic leukemia compared a novel 6-MP mini-tablet to a reference …
A tiny new pill for childhood leukemia works just as well as the standard version, but eating food before taking it dramatically reduces its…
Apr 10, 2026