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Acute Lymphoblastic Leukemia

Part of Leukemia

23 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Acute Lymphoblastic Leukemia

103 trials tracked for Acute Lymphoblastic Leukemia: 22 in phase 3 or 4 and 16 with published results. The most-cited published study has 349 citations.

103Trials tracked
22Phase 3 & 4
0Recruiting
16With published results
Phase distribution
Phase 4 4 Phase 3 18 Phase 2 62 Phase 1 10 Other / NA 9
  1. Phase 3 Phase 3 Trial of Blinatumomab vs Standard Chemotherapy in Pediatric Subjects With HIgh-Risk (HR) First Relapse B-precursor Acute Lymphoblastic Leukemia (ALL) Completed · 349 cited
  2. Phase 3 Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed · 245 cited
  3. Phase 3 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed · 230 cited
  4. Phase 3 Graft-Versus-Host Disease Prophylaxis in Treating Patients With Hematologic Malignancies Undergoing Unrelated Donor Peripheral Blood Stem Cell Transplant Completed · 114 cited
  5. Phase 3 Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma Completed · 101 cited
  6. Phase 3 Total Therapy Study XVI for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia Completed · 91 cited
Show 44 more trials
  1. Phase 3 A Study Of Inotuzumab Ozogamicin Versus Investigator's Choice Of Chemotherapy In Patients With Relapsed Or Refractory Acute Lymphoblastic Leukemia Completed · 79 cited
  2. Phase 3 A Study of the Safety and Effectiveness of Apixaban in Preventing Blood Clots in Children With Leukemia Who Have a Central Venous Catheter and Are Treated With Asparaginase Completed · 54 cited
  3. Phase 3 Phase III B in Acute Lymphoblastic Leukemia Completed · 51 cited
  4. Phase 3 Calaspargase Pegol or Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia Completed · 49 cited
  5. Phase 3 An Open-Label Study of JZP-458 (RC-P) in Patients With Acute Lymphoblastic Leukemia (ALL)/Lymphoblastic Lymphoma (LBL) Completed · 35 cited
  6. Phase 3 Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed · 33 cited
  7. Phase 4 Vaccinating Children After Chemotherapy Completed · 25 cited
  8. Phase 4 A Study Of Two Inotuzumab Ozogamicin Doses in Relapsed/ Refractory Acute Lymphoblastic Leukemia Transplant Eligible Patients Completed · 17 cited
  9. Phase 3 Tac, Mini-MTX, MMF Versus Tac, MTX for GVHD Prevention Completed · 12 cited
  10. Phase 3 Efficacy and Safety of the BiTE Antibody Blinatumomab in Chinese Adult Subjects With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia (ALL) Completed · 11 cited
  11. Phase 4 A Study of Inotuzumab Ozogamicin in Chinese Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia Completed
  12. Phase 4 Learning Impairments Among Survivors of Childhood Cancer Completed
  13. Phase 3 Therapy for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia Completed
  14. Phase 3 Dexamethasone Compared With Prednisone During Induction Therapy and Methotrexate With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia Completed
  15. Phase 3 Methotrexate or Pentostatin for Graft-versus-host Disease Prophylaxis in Risk-adapted Allogeneic Bone Marrow Transplantation for Hematologic Malignancies Completed
  16. Phase 3 A Severity-Adapted Clinical Trial of Diminished Bone Mineral Density in Acute Lymphoblastic Leukemia Survivors Completed
  17. Phase 2 T Cell Depletion for Recipients of HLA Haploidentical Related Donor Stem Cell Grafts Completed
  18. Phase 2 Clinical Study With Blinatumomab in Pediatric and Adolescent Patients With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia Completed
  19. Phase 2 Safety and Efficacy of BL-8040 for the Mobilization of Donor Hematopoietic Stem Cells and Allogeneic Transplantation in Patients With Advanced Hematological Malignancies Completed
  20. Phase 2 Reduced Intensity Flu/Mel/TBI Conditioning for HAPLO HCT Patients With Hematologic Malignancies Completed
  21. Phase 2 Combination Chemotherapy and Dasatinib in Treating Participants With Philadelphia Positive or BCR-ABL Positive Acute Lymphoblastic Leukemia. Completed
  22. Phase 2 Clofarabine-cyclophosphamide as Salvage Therapy for Refractory and Relapsed Acute Lymphoblastic Leukemia (ALL) Adults Completed
  23. Phase 2 Tocilizumab for the Prevention of Graft Versus Host Disease After Cord Blood Transplantation Completed
  24. Phase 2 Treatment of Adult Ph+ LAL With BMS-354825 Completed
  25. Phase 2 Study Evaluating AMD3100 for Transplantation of Sibling Donor Stem Cells in Patients With Hematological Malignancies Completed
  26. Phase 2 Safety and Efficacy of Donor T-lymphocytes Depleted ex Vivo of Host Alloreactive T-cells (ATIR) in Patients With a Hematologic Malignancy Who Received a Hematopoietic Stem Cell Transplantation From a Haploidentical Donor Completed
  27. Phase 2 Pilot of Abatacept-based Immunosuppression for Prevention of Acute GvHD During Unrelated Donor HCT Completed
  28. Phase 2 ALL Adult Consortium Trial: Adult ALL Trial Completed
  29. Phase 2 Treatment of Older Adults With Acute Lymphoblastic Leukemia Completed
  30. Phase 2 Vyxeos(CPX-351) in Adults w R/R Acute Lymphoblastic Leukemia Completed
  31. Phase 2 Busulfan/Clofarabine + Allogeneic Stem Cell Transplantation Completed
  32. Phase 2 Sirolimus, Cyclosporine, and Mycophenolate Mofetil in Preventing Graft-versus-Host Disease in Treating Patients With Blood Cancer Undergoing Donor Peripheral Blood Stem Cell Transplant Completed
  33. Phase 2 Therapy for Pediatric Relapsed or Refractory Acute Lymphoblastic Leukemia Completed
  34. Phase 2 Methods to Enhance the Safety and Effectiveness of Stem Cell Transplants Completed
  35. Phase 2 A Roll-over Study to Provide Continued Treatment With Lyophilized Pegaspargase (S95014) in Pediatric Patients With Acute Lymphoblastic Leukemia (ALL) Completed
  36. Phase 2 Sitagliptin Umbilical Cord Blood Transplant Study Completed
  37. Phase 2 Study of Augmented Hyper-CVAD in Acute Lymphoblastic Leukemia Salvage Completed
  38. Phase 2 Administration of GRASPA (Suspension of Erythrocytes Encapsulating L-asparaginase) in Elderly Patients With First Line Acute Lymphoblastic Leukemia Completed
  39. Phase 2 Combination Chemotherapy and Ofatumumab in Treating Patients With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma Completed
  40. Phase 2 Ibrutinib in Preventing Acute Leukemia in Patients After Reduced-Intensity Conditioning and Stem Cell Transplant Completed
  41. Phase 2 Nebulized Amphotericin B Lipid Complex in Invasive Pulmonary Aspergillosis in Paediatric Patients With Acute Leukaemia Completed
  42. Phase 2 A Study in Adults With Untreated Acute Lymphoblastic Leukemia Completed
  43. Phase 2 Clofarabine and Cyclophosphamide Combination in Acute Lymphoblastic Leukemia Patients Completed
  44. Phase 2 CMC-544 in Relapsed Refractory Acute Lymphoblastic Leukemia (ALL) Completed

Showing the 50 most-cited and recently-updated of 103 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Acute Lymphoblastic Leukemia: what the trials found

Several targeted and chimeric antigen receptor (CAR) therapies have demonstrated efficacy in patients with Acute Lymphoblastic Leukemia. Blinatumomab showed significant improvements in event-free survival (EFS) 7 and high rates of hematological response, including CR/CRh* or CRi, during the first two treatment cycles 20. Inotuzumab ozogamicin demonstrated a significantly higher percentage of patients achieving hematologic remission compared to standard treatments 13, with 81.8% to 47.7% reaching CR or CRi depending on the cohort 5. Additionally, Calaspargase Pegol-mknl was associated with high rates of complete remission at the end of induction (92.4% to 97.6%) and favorable event-free survival 16.

Asparaginase remains a cornerstone of treatment; studies show that its use, particularly in combination with other agents like Dasatinib, significantly impacts minimal residual disease (MRD) status at the end of induction 8. High-dose versus conventional dose PEG-asparaginase showed comparable rates of continuous complete remission 12. Additionally, while some trials investigated the impact of Lestaurtinib on MLL-R infants treated with combination chemotherapy and Asparaginase, no significant difference in event-free survival was observed between treatment arms 17.

Clinical assessments of supportive care and complications indicate that Cyclophosphamide is a standard component of therapy [9, 21]. Research into the impact of various agents on complications shows that tacrolimus may reduce the incidence of severe mucositis and acute GVHD compared to other regimens 19, while certain interventions like inotuzumab ozogamicin were associated with low rates of significant laboratory test shifts 4.

Research regarding the physiological impacts of the disease has identified significant differences in brain white matter volume between patients with Acute Lymphoblastic Leukemia and sibling controls, as well as between those with ALL and those with other types of brain tumors 6.

Recent results — preliminary, needs further review

  • Siltuximab was evaluated in a Phase 2 trial (N=24) for the treatment of this condition 1.
  • Cyclosporine was evaluated in a Phase 2 study where the median time to onset of Grade II-IV aGVHD by Day 100 was 34 days 2.

For the clinician treating this condition

  • Blinatumomab and Inotuzumab ozogamicin are established options for achieving high rates of hematologic response and improved event-free survival.
  • Asparaginase remains a core component of treatment, with significant implications for minimal residual disease (MRD) status.
  • Calaspargase Pegol-mknl is associated with high induction remission rates and favorable event-free survival.

AI synthesis of 13 cited trials, updated Jun 26, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Leukemia

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Questions about Acute Lymphoblastic Leukemia

Do factors like age or where a child lives change survival chances for Acute Lymphoblastic Leukemia?

Yes, age and geographic location affect survival in pediatric ALL; younger children and those in high-income countries generally have better outcomes.

Full answer →
Does taking fluoroquinolone medicine help reduce high fevers in children with Acute Lymphoblastic Leukemia?

Fluoroquinolone prophylaxis reduces febrile neutropenia (fever with low white blood cells) in children with ALL, but it is not a treatment for high fevers; it is a preventive measure given during chemotherapy.

Full answer →

All Acute Lymphoblastic Leukemia Articles