Review of observational data on non-sedated MRI feasibility in newly diagnosed ALL patients ages 3 to 10 years
Non-sedated MRI scans work for young leukemia patients with practice
This review synthesizes observational data from a community setting involving 17 newly diagnosed ALL patients and 30 controls ages 3 to 10 y…
Young children with acute lymphoblastic leukemia can undergo non-sedated MRI scans. Success rates improve with repeated visits and behaviora…
Review of observational data on vaccine antibody levels in children with acute lymphoblastic leukemia
Do routine vaccines work normally for children fighting acute lymphoblastic leukemia?
This narrative review synthesizes observational data regarding routine childhood measles and varicella zoster virus vaccines in children wit…
Children with leukemia have lower antibody levels after measles and chickenpox vaccines, but their immune cells still function well, suggest…
Registry-based systematic review maps non-pharmacological cancer trials in Africa
Are lifestyle changes for cancer in Africa being studied enough, or do we need more local trials?
This registry-based systematic review analyzed 53 trials of lifestyle and non-pharmacological interventions for cancer patients in Africa. I…
Advice from wealthy nations may not work in Africa, where most cancer lifestyle trials happen in Egypt while Kenya and Nigeria are largely i…
Pediatric ALL outcomes at Muhimbili National Hospital show 72% 12-month survival with no significant differences by demographic or care pathway factors.
The Long Road to a Leukemia Diagnosis in Tanzania
This retrospective observational cohort study evaluated 64 pediatric patients with acute lymphoblastic leukemia admitted to Muhimbili Nation…
In Tanzania, children with leukemia wait nearly a month for specialist care, and most die during the first weeks of treatment.
6-MP mini-tablets show bioequivalence to reference tablets in fasted children with ALL
A Tiny New Pill Could Transform Cancer Care for Children
Two open-label, randomized, crossover trials in children with acute lymphoblastic leukemia compared a novel 6-MP mini-tablet to a reference …
A tiny new pill for childhood leukemia works just as well as the standard version, but eating food before taking it dramatically reduces its…
Meta-analysis compares CAR T-cell constructs in 1540 relapsed/refractory B-ALL patients
Which CAR T-cell therapy works best for relapsed leukemia?
A systematic review and meta-analysis of 40 clinical trials involving 1540 R/R B-ALL patients found pooled complete remission rates of 83.4%…
For relapsed leukemia, CAR T-cell therapies using 4-1BB components targeting CD19 achieved the highest remission rates with fewer side effec…
Systematic review shows increased fat mass and decreased fat-free mass in children with acute lymphoblastic leukemia during treatment.
ALL Treatment Linked to Changes in Body Fat and Muscle in Young Patients
This systematic review and meta-analysis of 13 studies examined body composition changes in children and young people aged 0-21 years with a…
ALL treatment causes early fat gain and muscle loss in young patients that often persists long after therapy ends.
Phase I/II trial tests IMRT with chemotherapy before transplant for relapsed/refractory ALL/AML
Can a new radiation technique make stem cell transplants safer for leukemia?
A phase I/II trial record describes a study of intensity-modulated radiation therapy with etoposide and cyclophosphamide followed by allogen…
Doctors are testing a precise radiation technique to protect healthy organs while preparing patients for life-saving stem cell transplants.