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Home › Conditions › Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia

Part of Leukemia

16 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Acute Lymphoblastic Leukemia

103 trials tracked for Acute Lymphoblastic Leukemia: 22 in phase 3 or 4 and 16 with published results. The most-cited published study has 322 citations.

103Trials tracked
22Phase 3 & 4
0Recruiting
16With published results
Phase distribution
Phase 4 4 Phase 3 18 Phase 2 62 Phase 1 10 Other / NA 9
  1. Phase 3 Phase 3 Trial of Blinatumomab vs Standard Chemotherapy in Pediatric Subjects With HIgh-Risk (HR) First Relapse B-precursor Acute Lymphoblastic Leukemia (ALL) Completed · 322 cited
  2. Phase 3 Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed · 248 cited
  3. Phase 3 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed · 226 cited
  4. Phase 3 Graft-Versus-Host Disease Prophylaxis in Treating Patients With Hematologic Malignancies Undergoing Unrelated Donor Peripheral Blood Stem Cell Transplant Completed · 111 cited
  5. Phase 3 Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma Completed · 100 cited
  6. Phase 3 Total Therapy Study XVI for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia Completed · 89 cited
Show 44 more trials
  1. Phase 3 A Study Of Inotuzumab Ozogamicin Versus Investigator's Choice Of Chemotherapy In Patients With Relapsed Or Refractory Acute Lymphoblastic Leukemia Completed · 75 cited
  2. Phase 3 Phase III B in Acute Lymphoblastic Leukemia Completed · 48 cited
  3. Phase 3 A Study of the Safety and Effectiveness of Apixaban in Preventing Blood Clots in Children With Leukemia Who Have a Central Venous Catheter and Are Treated With Asparaginase Completed · 47 cited
  4. Phase 3 Calaspargase Pegol or Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia Completed · 46 cited
  5. Phase 3 Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed · 36 cited
  6. Phase 3 An Open-Label Study of JZP-458 (RC-P) in Patients With Acute Lymphoblastic Leukemia (ALL)/Lymphoblastic Lymphoma (LBL) Completed · 29 cited
  7. Phase 4 Vaccinating Children After Chemotherapy Completed · 25 cited
  8. Phase 4 A Study Of Two Inotuzumab Ozogamicin Doses in Relapsed/ Refractory Acute Lymphoblastic Leukemia Transplant Eligible Patients Completed · 17 cited
  9. Phase 3 Tac, Mini-MTX, MMF Versus Tac, MTX for GVHD Prevention Completed · 10 cited
  10. Phase 3 Efficacy and Safety of the BiTE Antibody Blinatumomab in Chinese Adult Subjects With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia (ALL) Completed · 9 cited
  11. Phase 4 A Study of Inotuzumab Ozogamicin in Chinese Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia Completed
  12. Phase 4 Learning Impairments Among Survivors of Childhood Cancer Completed
  13. Phase 3 Therapy for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia Completed
  14. Phase 3 Dexamethasone Compared With Prednisone During Induction Therapy and Methotrexate With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia Completed
  15. Phase 3 Methotrexate or Pentostatin for Graft-versus-host Disease Prophylaxis in Risk-adapted Allogeneic Bone Marrow Transplantation for Hematologic Malignancies Completed
  16. Phase 3 A Severity-Adapted Clinical Trial of Diminished Bone Mineral Density in Acute Lymphoblastic Leukemia Survivors Completed
  17. Phase 2 T Cell Depletion for Recipients of HLA Haploidentical Related Donor Stem Cell Grafts Completed
  18. Phase 2 Clinical Study With Blinatumomab in Pediatric and Adolescent Patients With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia Completed
  19. Phase 2 Safety and Efficacy of BL-8040 for the Mobilization of Donor Hematopoietic Stem Cells and Allogeneic Transplantation in Patients With Advanced Hematological Malignancies Completed
  20. Phase 2 Reduced Intensity Flu/Mel/TBI Conditioning for HAPLO HCT Patients With Hematologic Malignancies Completed
  21. Phase 2 Combination Chemotherapy and Dasatinib in Treating Participants With Philadelphia Positive or BCR-ABL Positive Acute Lymphoblastic Leukemia. Completed
  22. Phase 2 Clofarabine-cyclophosphamide as Salvage Therapy for Refractory and Relapsed Acute Lymphoblastic Leukemia (ALL) Adults Completed
  23. Phase 2 Tocilizumab for the Prevention of Graft Versus Host Disease After Cord Blood Transplantation Completed
  24. Phase 2 Treatment of Adult Ph+ LAL With BMS-354825 Completed
  25. Phase 2 Study Evaluating AMD3100 for Transplantation of Sibling Donor Stem Cells in Patients With Hematological Malignancies Completed
  26. Phase 2 Safety and Efficacy of Donor T-lymphocytes Depleted ex Vivo of Host Alloreactive T-cells (ATIR) in Patients With a Hematologic Malignancy Who Received a Hematopoietic Stem Cell Transplantation From a Haploidentical Donor Completed
  27. Phase 2 Pilot of Abatacept-based Immunosuppression for Prevention of Acute GvHD During Unrelated Donor HCT Completed
  28. Phase 2 ALL Adult Consortium Trial: Adult ALL Trial Completed
  29. Phase 2 Treatment of Older Adults With Acute Lymphoblastic Leukemia Completed
  30. Phase 2 Vyxeos(CPX-351) in Adults w R/R Acute Lymphoblastic Leukemia Completed
  31. Phase 2 Busulfan/Clofarabine + Allogeneic Stem Cell Transplantation Completed
  32. Phase 2 Sirolimus, Cyclosporine, and Mycophenolate Mofetil in Preventing Graft-versus-Host Disease in Treating Patients With Blood Cancer Undergoing Donor Peripheral Blood Stem Cell Transplant Completed
  33. Phase 2 Therapy for Pediatric Relapsed or Refractory Acute Lymphoblastic Leukemia Completed
  34. Phase 2 Methods to Enhance the Safety and Effectiveness of Stem Cell Transplants Completed
  35. Phase 2 A Roll-over Study to Provide Continued Treatment With Lyophilized Pegaspargase (S95014) in Pediatric Patients With Acute Lymphoblastic Leukemia (ALL) Completed
  36. Phase 2 Sitagliptin Umbilical Cord Blood Transplant Study Completed
  37. Phase 2 Study of Augmented Hyper-CVAD in Acute Lymphoblastic Leukemia Salvage Completed
  38. Phase 2 Administration of GRASPA (Suspension of Erythrocytes Encapsulating L-asparaginase) in Elderly Patients With First Line Acute Lymphoblastic Leukemia Completed
  39. Phase 2 Combination Chemotherapy and Ofatumumab in Treating Patients With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma Completed
  40. Phase 2 Ibrutinib in Preventing Acute Leukemia in Patients After Reduced-Intensity Conditioning and Stem Cell Transplant Completed
  41. Phase 2 Nebulized Amphotericin B Lipid Complex in Invasive Pulmonary Aspergillosis in Paediatric Patients With Acute Leukaemia Completed
  42. Phase 2 A Study in Adults With Untreated Acute Lymphoblastic Leukemia Completed
  43. Phase 2 Clofarabine and Cyclophosphamide Combination in Acute Lymphoblastic Leukemia Patients Completed
  44. Phase 2 CMC-544 in Relapsed Refractory Acute Lymphoblastic Leukemia (ALL) Completed

Showing the 50 most-cited and recently-updated of 103 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Xatmep receives FDA approval for pediatric acute lymphoblastic leukemia and polyarticular juvenile idiopathic arthritis
Hematology FDA Approval
Xatmep receives FDA approval for pediatric acute lymphoblastic leukemia and polyarticular juvenile idiopathic arthritis FDA approves Xatmep for pediatric leukemia and arthritis treatment options
The FDA has approved Xatmep for pediatric patients with acute lymphoblastic leukemia or active polyarticular juvenile idiopathic arthritis. …
The FDA has approved Xatmep to treat specific forms of childhood leukemia and arthritis, offering new options for young patients.
FDA May 30, 2026
Meta-analysis finds fluoroquinolone prophylaxis reduces febrile neutropenia in pediatric ALL
Oncology Meta-analysis
Meta-analysis finds fluoroquinolone prophylaxis reduces febrile neutropenia in pediatric ALL Fluoroquinolone antibiotics lower febrile neutropenia risk in children with acute lymphoblastic leukemia during treatment start
This systematic review and meta-analysis of 991 children with acute lymphoblastic leukemia found that fluoroquinolone prophylaxis reduced fe…
A review of children with acute lymphoblastic leukemia shows fluoroquinolone antibiotics reduce febrile neutropenia risk. This finding sugge…
May 1, 2026
Lyophilized pegaspargase shows similar activity to liquid form in pediatric ALL
Oncology RCT
Lyophilized pegaspargase shows similar activity to liquid form in pediatric ALL Lyophilized pegaspargase shows similar activity and safety to liquid form for pediatric leukemia patients
This phase 2 study in 89 pediatric ALL patients in Russia found that lyophilized pegaspargase had similar maximum plasma asparaginase activi…
A new form of pegaspargase works just like the liquid version for treating acute lymphoblastic leukemia in children in Russia.
May 1, 2026
Meta-analysis links perinatal factors to childhood acute leukemia risk
Hematology Meta-analysis
Meta-analysis links perinatal factors to childhood acute leukemia risk Perinatal factors linked to higher leukemia risk in children
This systematic review and meta-analysis of 85 studies examined perinatal factors and childhood acute leukemia risk.
A large analysis of 85 studies finds links between birth weight, maternal history, and cesarean sections with childhood leukemia risk.
May 1, 2026
Meta-analysis links maternal infection in pregnancy to childhood ALL risk
Hematology Meta-analysis
Meta-analysis links maternal infection in pregnancy to childhood ALL risk Maternal Infections During Pregnancy Linked to Higher Risk of Childhood Leukemia
This systematic review and meta-analysis of 26 studies found a modest association between maternal infection during pregnancy and childhood …
A large review of 26 studies found that maternal infections during pregnancy are associated with an increased risk of acute lymphoblastic le…
May 1, 2026
Review of observational data on non-sedated MRI feasibility in newly diagnosed ALL patients ages 3 to 10 years
Oncology
Review of observational data on non-sedated MRI feasibility in newly diagnosed ALL patients ages 3 to 10 years Non-sedated MRI scans work for young leukemia patients with practice
This review synthesizes observational data from a community setting involving 17 newly diagnosed ALL patients and 30 controls ages 3 to 10 y…
Young children with acute lymphoblastic leukemia can undergo non-sedated MRI scans. Success rates improve with repeated visits and behaviora…
medRxiv Apr 30, 2026
Review of observational data on vaccine antibody levels in children with acute lymphoblastic leukemia
Oncology
Review of observational data on vaccine antibody levels in children with acute lymphoblastic leukemia Do routine vaccines work normally for children fighting acute lymphoblastic leukemia?
This narrative review synthesizes observational data regarding routine childhood measles and varicella zoster virus vaccines in children wit…
Children with leukemia have lower antibody levels after measles and chickenpox vaccines, but their immune cells still function well, suggest…
medRxiv Apr 16, 2026
Registry-based systematic review maps non-pharmacological cancer trials in Africa
Oncology Meta-analysis
Registry-based systematic review maps non-pharmacological cancer trials in Africa Are lifestyle changes for cancer in Africa being studied enough, or do we need more local trials?
This registry-based systematic review analyzed 53 trials of lifestyle and non-pharmacological interventions for cancer patients in Africa.
Advice from wealthy nations may not work in Africa, where most cancer lifestyle trials happen in Egypt while Kenya and Nigeria are largely i…
Frontiers Apr 15, 2026
Pediatric ALL outcomes at Muhimbili National Hospital show 72% 12-month survival with no significant differences by demographic or care pathway factors
Pediatrics Cohort
Pediatric ALL outcomes at Muhimbili National Hospital show 72% 12-month survival with no significant differences by demographic or care pathway factors The Long Road to a Leukemia Diagnosis in Tanzania
This retrospective observational cohort study evaluated 64 pediatric patients with acute lymphoblastic leukemia admitted to Muhimbili Nation…
In Tanzania, children with leukemia wait nearly a month for specialist care, and most die during the first weeks of treatment.
Frontiers Apr 14, 2026
6-MP mini-tablets show bioequivalence to reference tablets in fasted children with ALL
Oncology RCT
6-MP mini-tablets show bioequivalence to reference tablets in fasted children with ALL A Tiny New Pill Could Transform Cancer Care for Children
Two open-label, randomized, crossover trials in children with acute lymphoblastic leukemia compared a novel 6-MP mini-tablet to a reference …
A tiny new pill for childhood leukemia works just as well as the standard version, but eating food before taking it dramatically reduces its…
Apr 10, 2026
Red blood cell parameters predict sepsis in children with ALL and chemotherapy-induced neutropenia
Pediatrics Cohort
Red blood cell parameters predict sepsis in children with ALL and chemotherapy-induced neutropenia A Simple Blood Test Could Warn of Sepsis in Children on Chemotherapy
This retrospective cohort study evaluated red blood cell parameters in children with acute lymphoblastic leukemia who developed chemotherapy…
Doctors may have found a faster, simpler way to spot a deadly infection in children undergoing cancer treatment.
Frontiers Apr 10, 2026
Meta-analysis compares CAR T-cell constructs in 1540 relapsed/refractory B-ALL patients
Hematology Meta-analysis
Meta-analysis compares CAR T-cell constructs in 1540 relapsed/refractory B-ALL patients Which CAR T-cell therapy works best for relapsed leukemia?
A systematic review and meta-analysis of 40 clinical trials involving 1540 R/R B-ALL patients found pooled complete remission rates of 83.4%…
For relapsed leukemia, CAR T-cell therapies using 4-1BB components targeting CD19 achieved the highest remission rates with fewer side effec…
Apr 8, 2026

Research across Leukemia

Related studies from across the Leukemia family.

AZA or LDAC combined with venetoclax likely improves mortality, remission, and quality of life
Oncology Meta-analysis
AZA or LDAC combined with venetoclax likely improves mortality, remission, and quality of life New combinations show promise for older adults with myeloid leukemia
This systematic review and meta-analysis of 47 studies evaluated treatments for older adults with AML ineligible for conventional chemothera…
Combining specific drugs like venetoclax with other treatments may improve survival and quality of life for older adults with acute myeloid …
Jun 12, 2026
7-day venetoclax with intensive chemotherapy achieves 90.3% composite complete remission in AML
Hematology RCT
7-day venetoclax with intensive chemotherapy achieves 90.3% composite complete remission in AML Trial shows venetoclax combined with chemotherapy for AML
This clinical trial of 259 newly diagnosed patients with acute myeloid leukemia found a 90.3% composite complete remission rate using a 7-da…
A new clinical trial shows that a short 7-day course of venetoclax combined with chemotherapy can achieve high remission rates in AML patien…
Jun 8, 2026
Rate of drug concentration rise alters hemodynamic responses and mortality risk in coronary heart disease patients
Drug Pipeline Meta-analysis
Rate of drug concentration rise alters hemodynamic responses and mortality risk in coronary heart disease patients New analysis shows how fast drug levels change affects patient safety outcomes
This narrative review and theoretical framework synthesizes evidence on rate-dependent pharmacology. It highlights divergent hemodynamic res…
This review explains that how quickly medicine levels rise in the body matters for safety. Fast changes can cause more harm than slow ones, …
medRxiv Jun 4, 2026
Novel strategies aim to separate GVHD from GVL effects in allo-HCT for AML
Oncology Sys. Review
Novel strategies aim to separate GVHD from GVL effects in allo-HCT for AML Novel strategies aim to separate GVHD from GVL effects in leukemia patients
This narrative review explores novel therapeutic strategies to separate graft-versus-host disease (GVHD) from graft-versus-leukemia (GVL) ef…
A narrative review explores new ways to treat acute myeloid leukemia while managing side effects after stem cell transplants.
Frontiers Jun 4, 2026
HMA-venetoclax yields 50% overall response rate in relapsed/refractory AML meta-analysis
Hematology Meta-analysis
HMA-venetoclax yields 50% overall response rate in relapsed/refractory AML meta-analysis Combination therapy shows response in relapsed leukemia
This systematic review and meta-analysis of 2289 adults with relapsed/refractory acute myeloid leukemia found that hypomethylating agents pl…
For adults with relapsed leukemia, combining two drugs led to a 50% response rate, offering a potential new option for a tough situation.
Jun 1, 2026
Antibody-based therapies offer potential efficacy and durability options for relapsed refractory acute myeloid leukemia patients
Allergy & Immunology Sys. Review
Antibody-based therapies offer potential efficacy and durability options for relapsed refractory acute myeloid leukemia patients Review explores antibody therapies for relapsed acute myeloid leukemia
This narrative review examines antibody-based therapies for relapsed or refractory acute myeloid leukemia. The authors discuss potential eff…
A review looks at antibody-based therapies for patients with relapsed acute myeloid leukemia, comparing them to traditional treatment option…
Frontiers Jun 1, 2026
Fertility preservation in female leukemia patients carries risks of leukemic cell contamination and disease reintroduction
Diabetes & Endocrinology Sys. Review
Fertility preservation in female leukemia patients carries risks of leukemic cell contamination and disease reintroduction Fertility preservation options carry risks for female leukemia patients
This review examines fertility preservation strategies for female patients with leukemia. The authors note that oocyte or embryo cryopreserv…
Fertility preservation strategies for female leukemia patients face safety concerns like disease reintroduction and contamination risks that…
Frontiers Jun 1, 2026
Reduced-intensity ATRA plus arsenic with GO or low-dose anthracycline improves event-free survival in high-risk APL
Hematology Meta-analysis
Reduced-intensity ATRA plus arsenic with GO or low-dose anthracycline improves event-free survival in high-risk APL New analysis shows reduced-intensity treatment works well for high-risk leukemia patients compared to standard intensive chemotherapy
This systematic review and meta-analysis of 1,323 patients with high-risk acute promyelocytic leukemia found that reduced-intensity inductio…
A large review of over 1,300 patients found that a gentler treatment plan worked just as well as harsher chemotherapy. This approach may hel…
Frontiers May 29, 2026
Review of glycolytic metabolism in acute myeloid leukemia cells notes research scope and limitations
Drug Pipeline Sys. Review
Review of glycolytic metabolism in acute myeloid leukemia cells notes research scope and limitations Scientists examine how sugar metabolism affects acute myeloid leukemia cells
This narrative review examines glycolytic enzymes and glycolytic metabolism within acute myeloid leukemia (AML) cells. The authors synthesiz…
This review looks at how glycolytic enzymes and metabolism impact acute myeloid leukemia cells, offering new insights into this serious bloo…
Frontiers May 25, 2026
Narrative review suggests idiotype-directed CAAR-T therapy remains hypothetical for B-cell malignancies
Hematology Sys. Review
Narrative review suggests idiotype-directed CAAR-T therapy remains hypothetical for B-cell malignancies Idiotype-directed CAAR-T therapy remains a hypothesis for B-cell malignancies
This narrative review discusses idiotype-directed CAAR-T therapy for B-cell malignancies including chronic lymphocytic leukemia and indolent…
A narrative review suggests idiotype-directed CAAR-T therapy is a theoretical option for B-cell cancers, not a current treatment.
Frontiers May 23, 2026
Scoping review examines imatinib gonadotoxicity in males with chronic myeloid leukemia or gastrointestinal stromal tumors
Hematology Sys. Review
Scoping review examines imatinib gonadotoxicity in males with chronic myeloid leukemia or gastrointestinal stromal tumors Young Men's Fertility at Risk with Common Cancer Drug Imatinib
This scoping review synthesizes evidence on imatinib effects in males with chronic myeloid leukemia or gastrointestinal stromal tumors. Twen…
• Imatinib harms sperm production more in younger men permanently • Helps doctors counsel teens and young adults before treatment • Not a tr…
Frontiers May 15, 2026
Case report and review: azacytidine plus ruxolitinib in connective tissue disease with CMML and myelofibrosis
Allergy & Immunology Sys. Review
Case report and review: azacytidine plus ruxolitinib in connective tissue disease with CMML and myelofibrosis A single patient found relief from blood cancer with a new drug combo
This case report and literature review describes a 52-year-old male with connective tissue disease, chronic myelomonocytic leukemia, and mye…
One man with blood cancer saw his fever and anemia improve after two years on a specific drug mix, offering a glimpse into potential new tre…
Frontiers May 14, 2026

Questions about Acute Lymphoblastic Leukemia

Do factors like age or where a child lives change survival chances for Acute Lymphoblastic Leukemia?

Yes, age and geographic location affect survival in pediatric ALL; younger children and those in high-income countries generally have better outcomes.

Full answer →
Does taking fluoroquinolone medicine help reduce high fevers in children with Acute Lymphoblastic Leukemia?

Fluoroquinolone prophylaxis reduces febrile neutropenia (fever with low white blood cells) in children with ALL, but it is not a treatment for high fevers; it is a preventive measure given during chemotherapy.

Full answer →

All Acute Lymphoblastic Leukemia Articles