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Home › Medications › onabotulinumtoxinA

onabotulinumtoxinA

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials of onabotulinumtoxinA

31 trials tracked of onabotulinumtoxinA: 24 in phase 3 or 4 and 7 with published results. The most-cited published study has 192 citations.

31Trials tracked
24Phase 3 & 4
0Recruiting
7With published results
Phase distribution
Phase 4 13 Phase 3 11 Phase 2 6 Other / NA 1
  1. Phase 4 A Long-term Efficacy, Safety, and Tolerability Study of BOTOX® in Patients With Chronic Migraine Completed · 192 cited
  2. Phase 4 Efficacy and Safety Study of BOTOX® Compared to Topiramate for the Prevention of Chronic Migraine in Adults Completed · 108 cited
  3. Phase 4 The Treatment of Glabellar Frown Lines Completed · 46 cited
  4. Phase 3 Safety and Efficacy Study of OnabotulinumtoxinA for the Treatment of Urinary Incontinence Due to Neurogenic Detrusor Overactivity (NDO) in Non-Catheterizing Patients With Multiple Sclerosis (MS) Completed · 25 cited
  5. Phase 4 Functional Effects of Botox on the Brain Using MRS and fMRI Completed · 21 cited
  6. Phase 4 OnabotulinumtoxinA (BOTOX®) Treatment for Urinary Incontinence in Patients With Overactive Bladder Completed · 17 cited
Show 25 more trials
  1. Phase 4 Evaluation of an Alternative Injection Paradigm for OnabotulinumtoxinA (BOTOX®) in the Treatment of Overactive Bladder in Patients With Urinary Incontinence Completed · 1 cited
  2. Phase 4 Patient Satisfaction Study of Combined Facial Treatment With BOTOX® Cosmetic, JUVÉDERM® and LATISSE® (HARMONY Study) Completed
  3. Phase 4 Calcitonin Gene-related Peptide Levels in Chronic Migraine Completed
  4. Phase 4 Study of BOTOX and JUVEDERM for Treatment of Moderate to Severe Facial Wrinkles and Folds Completed
  5. Phase 4 Duration of Benefit for OnabotulinumtoxinA in Treatment of Chronic Migraine Completed
  6. Phase 4 Use of a Treatment Benefit Questionnaire in Patients With Chronic Migraine Treated With OnabotulinumtoxinA (BOTOX®) Completed
  7. Phase 4 A Study of Subject Satisfaction With BOTOX® Cosmetic Treatment in Facial Rhytides Completed
  8. Phase 4 A Study to Evaluate the Tolerability of Botox and Topiramate or Botox and Placebo and Effect on Cognitive Efficiency Completed
  9. Phase 3 A Safety and Efficacy Study of OnabotulinumtoxinA in Forehead and Glabellar Facial Rhytides Completed
  10. Phase 3 A Safety and Efficacy Study of OnabotulinumtoxinA in Upper Facial Rhytides Completed
  11. Phase 3 Study of OnabotulinumtoxinA (BOTOX®) for Urinary Incontinence Due to Neurogenic Detrusor Overactivity in Pediatric Patients Completed
  12. Phase 3 A Long-Term Extension Study of OnabotulinumtoxinA (BOTOX®) for Urinary Incontinence Due to Neurogenic Detrusor Overactivity Completed
  13. Phase 3 A Study To Assess the Safety and Effects of OnabotulinumtoxinA (BOTOX) Intramuscular Injection in Adult Participants With Platysma Prominence Completed
  14. Phase 3 A Study To Assess the Safety and Effects of OnabotulinumtoxinA (BOTOX) Intramuscular Injection in Adult Participants With Moderate to Severe Platysma Prominence Completed
  15. Phase 3 A Study To Assess the Safety of OnabotulinumtoxinA (BOTOX) Intramuscular Injection in Adult Participants With Platysma Prominence Completed
  16. Phase 3 Study of Botulinum Toxin Type A for the Treatment of Patients With Idiopathic Overactive Bladder With Urinary Incontinence Completed
  17. Phase 3 Botulinum Toxin Type A for the Treatment of Patients With Idiopathic Overactive Bladder With Urinary Incontinence Completed
  18. Phase 3 Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Crow's Feet Lines Completed
  19. Phase 2 BOTOX® (onabotulinumtoxinA) Treatment of Masseter Muscle Prominence Completed
  20. Phase 2 Botulinum Toxin A Single Blind Split-Face Randomized Pilot Study Completed
  21. Phase 2 Effectiveness of Onabotulinumtoxin A (Botox) in Pediatric Patients Experiencing Migraines: A Study in the Pediatric Pain Population Completed
  22. Phase 2 Study to Demonstrate Safety and Duration of Effect of 40 Units of PrabotulinumtoxinA-xvfs to Treat Glabellar Lines Completed
  23. Phase 2 OnabotulinumtoxinA as Treatment for Major Depressive Disorder in Adult Females Completed
  24. Phase 2 BOTOX® Efficacy and Safety in the Treatment of Knee Osteoarthritis Completed
  25. N/A A Retrospective Study to Evaluate the Effectiveness and Benefit of onabotulinumtoxinA in Patients With Chronic Migraines Completed

Showing the 31 most-cited and recently-updated of 31 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
OnabotulinumtoxinA 72 U reduces masseter prominence versus placebo in adults
Drug Pipeline RCT
OnabotulinumtoxinA 72 U reduces masseter prominence versus placebo in adults Does this shot really shrink a prominent jaw muscle, or is it just a placebo effect?
This Phase 3, randomized, placebo-controlled trial in 376 adults with Grade 4 or 5 masseter muscle prominence found that onabotulinumtoxinA …
An injection shrinks prominent jaw muscles in over half of adults with severe cases, narrowing the lower face quickly with mostly mild side …
Apr 18, 2026