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Home › Medications › Progesterone

Progesterone

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of Progesterone

45 trials tracked of Progesterone: 16 in phase 3 or 4 and 5 with published results. The most-cited published study has 496 citations.

45Trials tracked
16Phase 3 & 4
0Recruiting
5With published results
Phase distribution
Phase 4 6 Phase 3 10 Phase 2 10 Phase 1 3 Other / NA 16
  1. Phase 3 Efficacy and Safety Study of Intravenous Progesterone in Patients With Severe Traumatic Brain Injury Completed · 496 cited
  2. Phase 3 A Safety and Efficacy Study of the Combination Estradiol and Progesterone to Treat Vasomotor Symptoms Completed · 25 cited
  3. Phase 4 Progesterone and Brain Imaging Study Completed · 12 cited
  4. Phase 3 Progesterone Effect on Individuals Diagnoses With AD and PTSD. Completed · 8 cited
  5. Phase 4 Influence of Testosterone Administration on Drug-Induced QT Interval Prolongation and Torsades de Pointes Completed · 7 cited
  6. Phase 4 Does Oral Micronized Progesterone Shorten Time of Symptoms From Concussion Completed
Show 39 more trials
  1. Phase 4 Perimenopausal Effects of Estradiol on Reward Responsiveness Completed
  2. Phase 4 Reducing the Risk of Drug-Induced QT Interval Lengthening in Women Completed
  3. Phase 4 Progesterone Serum Levels in Subfertile Female Patients Undergoing in Vitro Fertilisation (IVF) Completed
  4. Phase 3 Progestin Primed Double Stimulation Protocol Versus Flexible GnRH Antagonist Protocol in Poor Responders Completed
  5. Phase 3 PREGNANT Short Cervix Trial Completed
  6. Phase 3 To Investigate Efficacy and Safety of a Single Injection of Org 36286 for Ovarian Stimulation Using Daily Recombinant FSH as Reference (Ensure)(P05690/MK-8962-001) Completed
  7. Phase 3 A Study to Investigate the Efficacy and Safety of a Single Injection of Corifollitropin Alfa (Organon 36286) for Ovarian Stimulation Using Daily Recombinant Follicle Stimulating Hormone (FSH) as Reference (P05787) Completed
  8. Phase 3 Corifollitropin Alfa in Participants Undergoing Repeated Controlled Ovarian Stimulation (COS) Cycles Using a Multiple Dose Gonadatropin Releasing Hormone (GnRH) Antagonist Protocol (Study 38825)(P05714) Completed
  9. Phase 3 Subcutaneous Progesterone Versus Vaginal Progesterone Gel for Luteal Phase Support in Patients Undergoing In-Vitro Fertilization (IVF) Completed
  10. Phase 3 Subcutaneous Progesterone Versus Vaginal Progesterone Tablets for Luteal Phase Support in In Vitro Fertilization (IVF) Completed
  11. Phase 2 The Role of Hormones in Postpartum Mood Disorders Completed
  12. Phase 2 The Effects of Reproductive Hormones on Mood and Behavior Completed
  13. Phase 2 Progesterone for Smoking Relapse Prevention Following Delivery Completed
  14. Phase 2 Influence of Progesterone Administration on Drug-Induced QT Interval Lengthening Completed
  15. Phase 2 Safety and Efficacy of Elagolix in Pre-Menopausal Women With Heavy Uterine Bleeding and Uterine Fibroids Completed
  16. Phase 2 Randomized Trial of Maternal Progesterone Therapy Completed
  17. Phase 2 Sex Hormones and Orthostatic Tolerance Completed
  18. Phase 2 Impact of Progesterone on Stress Reactivity and Cannabis Use Completed
  19. Phase 2 Atherosclerosis, Immune Mediated Inflammation and Hypoestrogenemia in Young Women Completed
  20. Phase 2 Lutropin Alfa in Women at Risk of Poor Response Completed
  21. Phase 1 Progesterone for Cannabis Withdrawal Completed
  22. Phase 1 A Treatment Study for Premenstrual Syndrome (PMS) Completed
  23. Phase 1 PRevention Of Methamphetamine Use Among Postpartum Women Trial (PROMPT) Completed
  24. N/A Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established in Clinical Trial P05714 (Care Program)(P05715) Completed
  25. N/A Estrogen Sensitivity and Ovulatory Dysfunction in Obesity Completed
  26. N/A Impact of GABA-Enhancing Agents on Cortical GABA Concentrations Across the Menstrual Cycle in Women Completed
  27. N/A Sex Steroids, Sleep, and Metabolic Dysfunction in Women Completed
  28. N/A Neurophysiology of Postpartum Depression in an Experimental Model of Pregnancy and Parturition Completed
  29. N/A Follow-up Study of Frozen-thawed Embryo Transfer (FTET) Cycles After Cryopreservation of Embryos in Clinical Trial P05787 (P05716) Completed
  30. N/A Progesterone & Postpartum Relapse to Smoking Completed
  31. N/A Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established in Clinical Trial P05690 (Care Program) (P05710) Completed
  32. N/A Follow-up Protocol on the Outcome of Frozen-thawed Embryo Transfer Cycles From Clinical Trial P05690 (P05711) Completed
  33. N/A Relationship Between the Menstrual Cycle and Heart Disease in Women Completed
  34. N/A Effect of Metformin on Sensitivity of the GnRH Pulse Generator to Suppression by Estradiol and Progesterone Completed
  35. N/A Progesterone for Postpartum Cocaine Relapse Completed
  36. N/A Progesterone for the Treatment of Cocaine Dependence - 1 Completed
  37. N/A Sex Differences, Hormones & Smoking Cessation Completed
  38. N/A Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established in Clinical Trial P05787 (P05712) Completed
  39. N/A Hormones and Reduction in Co-users of Marijuana and Nicotine Completed

Showing the 45 most-cited and recently-updated of 45 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Dydrogesterone vs micronized progesterone for ongoing pregnancy in frozen embryo transfer
Drug Pipeline RCT
Dydrogesterone vs micronized progesterone for ongoing pregnancy in frozen embryo transfer New Fertility Drug Option May Be Easier to Use, But Is It as Effective?
This pilot randomized controlled trial compared dydrogesterone to micronized vaginal progesterone in 150 women undergoing artificial cycle f…
For many women trying to get pregnant through IVF, the final step can feel uncomfortable.
Frontiers Apr 24, 2026
Progesterone exposure duration affects live birth rates depending on blastocyst expansion stage in frozen embryo transfers
Diabetes & Endocrinology Cohort
Progesterone exposure duration affects live birth rates depending on blastocyst expansion stage in frozen embryo transfers Progesterone Timing Doubles IVF Success for Some
This retrospective cohort study evaluated 2,058 women undergoing single frozen–thawed day-6 blastocyst transfer.
You’ve waited weeks. Maybe years. You’ve tracked your cycle, taken injections, and held your breath through every step.
Frontiers Apr 23, 2026
Review suggests precision pharmacology for progesterone in recurrent pregnancy loss
Drug Pipeline RCT
Review suggests precision pharmacology for progesterone in recurrent pregnancy loss Why Progesterone Might Finally Work For You
This review addresses recurrent pregnancy loss in patients with recurrent pregnancy loss.
This new approach moves away from guessing to use, aiming to give the right medicine to the right patient at the right time.
Frontiers Apr 19, 2026
Letrozole protocol associated with higher live birth and lower adverse outcomes versus estrogen-progesterone in ovulation disorder FET
Psychiatry Cohort
Letrozole protocol associated with higher live birth and lower adverse outcomes versus estrogen-progesterone in ovulation disorder FET Letrozole Prep Boosts Live Births, Lowers Risks
This single-center retrospective cohort study compared ovulation induction using Letrozole against an artificial programmed protocol using e…
Women with ovulation issues who take Letrozole before frozen embryo transfers have higher live birth rates and lower risks of miscarriage an…
Frontiers Apr 13, 2026