Targeted strategies like senolytics and PFKFB3 blockers show preclinical efficacy in chronic kidney disease
New research explores how cells drive chronic kidney disease
This narrative review explores the mechanisms of necroptotic tubular epithelial cell death and glycolytic reprogramming in chronic kidney di…
Scientists identified a self-amplifying cycle of cell death and aging that drives scarring in chronic kidney disease.
cGAS-STING pathway activation drives inflammation, fibrosis, and podocyte injury in various kidney diseases
New research identifies a key pathway in kidney disease progression
This systematic review synthesizes preclinical data on the cGAS-STING signaling pathway's role in acute kidney injury, chronic kidney diseas…
A specific signaling pathway called cGAS-STING acts as a central hub, linking inflammation and metabolism to several types of serious kidney…
Review highlights microglia-targeted therapies as emerging Alzheimer's strategy beyond amyloid
New Alzheimer's treatment targets brain inflammation instead of plaques
This narrative review synthesizes evidence on microglia-targeted therapeutic strategies for Alzheimer's disease, including TREM2 agonism, CD…
Forget the plaque-clearing drugs. The real action in Alzheimer's research is now inside your brain's own immune cells, and scientists say ta…