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Gastroenterology
Sys. Review
Gut-brain axis dysregulation links Crohn's disease activity with heterogeneous mood improvements from emerging therapies
Newer gut brain therapies show promise for Crohn's disease depression
This narrative review explores the gut-brain axis as a mechanism for depression in patients with Crohn's disease. The authors synthesize evi…
Living with Crohn's disease and depression is a heavy burden. New research explores how targeting the gut brain axis could help manage both …
Frontiers
Aug 25, 2026
Orthopedics & Sports Medicine
Meta-analysis
Serotonergic antidepressants associated with more than a 2-fold increase in odds of pseudarthrosis
Antidepressant use linked to higher risk of spinal fusion failure
This meta-analysis of 37,554 adult patients undergoing cervical or lumbar spinal fusion found that serotonergic antidepressant use was assoc…
A large review suggests that patients taking certain antidepressants may face a higher risk of failed spinal fusions during surgery.
Aug 3, 2026